Role of autophagy in neurotoxic protein's clearance following post-ischemic stroke: where we are and what we know? [0.03%]
自噬在缺血性脑卒中后神经毒性蛋白清除中的作用：我们目前所处的研究阶段及已知的研究内容？
Sareh Kazmi,Fatemeh Farokhi-Sisakht,Samin Davoody et al.
Sareh Kazmi et al.
Repeated naloxone-induced morphine withdrawal alters blood brain barrier and blood spinal cord barrier integrity in mice [0.03%]
纳洛酮诱导的大鼠吗啡戒断会改变血脑屏障和血液脊髓屏障的完整性
Yuta Kohro,Craig E Brown,Tuan Trang
Yuta Kohro
Passage of molecules across the central nervous system is tightly regulated by the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB), which restrict entry of many substances, including opioid medications. Here, we examined the ...
Multi-omics integration reveals the role of N6-methyladenosine in epilepsy, ischemic stroke, and vascular dementia [0.03%]
多组学整合揭示N6-甲基腺苷在癫痫、缺血性卒中和血管性痴呆中的作用
Xudong Zhang,Yuhao Xu,Hai Hu et al.
Xudong Zhang et al.
Background: N6-methyladenosine (m6A) methylation is an essential epigenetic modification that regulates mRNA stability, splicing, and translation. Its role in neurological diseases, including epilepsy, ischemic stroke, an...
Visualization of the existence of LEAP2 in the nucleus accumbens and its role in amphetamine-induced locomotor activity [0.03%]
LEAP2在伏隔核中的定位及其在冰毒致小鼠异常运动行为中作用的初步研究
Seohyeon Lee,Ga Young Yoo,Hyung Shin Yoon et al.
Seohyeon Lee et al.
The nucleus accumbens (NAcc) is a key brain region in reward circuitry, mediating responses to psychostimulants, such as amphetamine (AMPH), including locomotor activity. This effect is known to be enhanced by the orexigenic neuropeptide gh...
CSF Amyloid-β42 associates with neuropsychiatric and cognitive outcomes via cerebral glucose metabolism [0.03%]
脑葡萄糖代谢介导CSF Aβ42与神经精神和认知结果之间的关系
Ali Azargoonjahromi,Hamide Nasiri;Alzheimer’s Disease Neuroimaging Initiative#
Ali Azargoonjahromi
Amyloid-β42 (Aβ42) regulates synaptic plasticity and memory formation at physiological levels in the brain, but in Alzheimer's disease (AD), it can disrupt brain function and glucose metabolism. This disruption contributes to cognitive de...
The medial prefrontal cortex encodes procedural rules as sequential neuronal activity dynamics [0.03%]
内侧前额叶皮层通过序列神经元动态编码程序规则
Shuntaro Ohno,Masanori Nomoto,Kaoru Inokuchi
Shuntaro Ohno
The prefrontal cortex plays a crucial role in procedural rule learning; however, the specific neuronal mechanism through which it represents rules is unknown. We hypothesized that sequential neuronal activities in the prefrontal cortex enco...
Systemic semaglutide provides a mild vasoprotective and antineuroinflammatory effect in a rat model of ocular hypertensive glaucoma [0.03%]
系统性塞meglutide在实验性青光眼模型中具有轻度血管保护和抗神经炎症作用
Zaynab A Mouhammad,Anne Rombaut,Mariana Yolotzin García Bermúdez et al.
Zaynab A Mouhammad et al.
Glaucoma is a neurodegenerative disease affecting retinal ganglion cells (RGCs), with a multifactorial genesis that includes inflammation and vascular dysfunction. Emerging evidence suggests that glucagon-like peptide 1 receptor agonist (GL...
Distinct composition of different types of Abeta plaques in the pathogenesis of Alzheimer's disease and the role of neutrophil-derived myeloperoxidase [0.03%]
阿尔茨海默病发病机制中不同类型的淀粉样蛋白斑组成及中性粒细胞来源髓过氧化物酶的作用
Jianru Sun,Xiangqi Shao,Xue Wang et al.
Jianru Sun et al.
Alzheimer's disease (AD) is an age-related neurodegenerative disorder. Different types of Aβ plaques are likely to play distinct roles in the brains of patients with AD. In this study, through the combination of pathological techniques and...
Effects of vincristine on the properties of low threshold mechanoreceptors and high threshold mechanoreceptors in the hindpaw glabrous skin of mice [0.03%]
长春新碱对小鼠后爪光滑皮肤低阈值机械感受器和高阈值机械感受器性质的影响
Akihiro Yamada,Ayaka I Yamada,Jennifer Ling et al.
Akihiro Yamada et al.
Vincristine is an important chemotherapy drug to treat various types of cancer, but it induces peripheral neuropathy, leading to numbness and mechanical allodynia in the hands and feet of patients. The peripheral neuropathy is a dose-limiti...
Chronic voluntary exercise induces plasticity of noradrenaline-activated dopamine D1-like receptor signaling [0.03%]
慢性自愿运动诱导去甲肾上腺素激活多巴胺D1样受体信号转导的可塑性
Katsunori Kobayashi
Katsunori Kobayashi
Physical exercise has lasting positive influence on mental health. However, its cellular substrate remains to be elucidated. Recently, dopamine D1-like receptor activation induced by noradrenaline has been suggested to underlie exercise-dep...