FCHO1 fine-tunes synaptic vesicle endocytosis in an activity-dependent manner [0.03%]
FCHO1以活动依赖的方式精调突触囊泡的内陷作用
Hyun Jung Lee,Wongyoung Lee,Sung Hyun Kim
Hyun Jung Lee
Synaptic vesicle (SV) recycling is critical for sustaining neurotransmission. Although FCHO1, a protein containing both an F-BAR domain and a μ-homology (μ-HD) domain, is recognized as a nucleator of clathrin-mediated endocytosis in non-n...
Hippocampal transcriptome profiling in a 22q11.2 deletion syndrome mouse model: comparison with human schizophrenia [0.03%]
22q11.2缺失综合征小鼠海马转录谱的特征及其与人类精神分裂症的比较研究
Hinano Yonemaru,Takaaki Ozawa,Takatoshi Hikida
Hinano Yonemaru
22q11.2 deletion syndrome (22q11.2DS) confers one of the highest genetic risks for schizophrenia, yet the molecular mechanisms remain incompletely understood. We performed comprehensive RNA sequencing of the dorsal hippocampus in Df1/+ mice...
Repeated sleep deprivation selectively reactivates hippocampal CA1 pyramidal neurons [0.03%]
反复睡眠剥夺有选择地重新激活海马CA1锥体神经元
Yutong Wang,Emily N Walsh,Junko Kasuya et al.
Yutong Wang et al.
Sleep supports a variety of physiological processes, ranging from metabolic to immune system homeostasis, and plays a critical role in cognition and memory. A brief period of sleep loss impairs memory, particularly hippocampus-dependent mem...
Hyeyoung Shin
Hyeyoung Shin
Perception is a process of inference, whereby incoming sensory evidence is interpreted based on prior expectations about the sensory world. Thus, the neural code of perception should be evaluated based on how optimally it computes perceptua...
APP family in inhibitory neurons controls inhibitory recruitment and short-term plasticity in the hippocampus [0.03%]
抑制性神经元中的App家族调控海马区的抑制性突触募集和短时程可塑性
Sang Hun Lee,Jongkyun Kang,Chen Zhang et al.
Sang Hun Lee et al.
Amyloid precursor protein (APP) is associated with both familial and sporadic forms of Alzheimer's disease. We previously reported that APP and its family members, amyloid precursor-like proteins 1 and 2 (APLP1 and APLP2), regulate intrinsi...
m6A RNA methylation in neural plasticity, brain aging, and neurodegenerative vulnerability [0.03%]
神经可塑性、脑衰老和神经退行性疾病易感性的m6A RNA甲基化研究
Xuehua Zhou,Peiyang Yu,Xia Shen
Xuehua Zhou
m6A is a pervasive post-transcriptional RNA modification that regulates RNA splicing, stability, localization, and translation in the brain. In this review, we outline the core m6A regulatory machinery and summarize its spatial organization...
Platelet proteomic signatures of amyloid β-positive mild cognitive impairment and Alzheimer's disease [0.03%]
淀粉样蛋白β阳性轻度认知障碍和阿尔茨海默病的血小板蛋白质组标志物
Yeong Eun Cho,Andrew Kim,Hyeong Min Lee et al.
Yeong Eun Cho et al.
Early detection of Alzheimer's disease (AD) is critical for preventing disease progression. Blood platelets have emerged as a useful peripheral source for AD diagnosis. However, the identification of proteomics-based platelet biomarkers of ...
Central nervous system pericytes express soluble ST2 in inflammation and injury [0.03%]
中枢神经系统周细胞在炎症和损伤时表达可溶性ST2蛋白质
Deidre Jansson,Blake Highet,Susan Li et al.
Deidre Jansson et al.
Brain pericytes are mediators of neuroinflammation, as evidenced in vitro, in animal models and humans. We and others have identified the platelet-derived growth factor (PDGF)-BB -PDGF receptor beta (PDGFRB) pathway as a key modulator of in...
Neuro-immune interactions underlying autoimmune diseases: insights from brain imaging data [0.03%]
自身免疫疾病下的神经免疫相互作用：来自大脑影像数据的启示
Junxiang Gu,Zixuan Xing,Jian Wang et al.
Junxiang Gu et al.
Autoimmune diseases (AIDs) result from intricate interactions among genetic, environmental and immune factors, with emerging evidence underscoring the role of the central nervous system (CNS) in their pathogenesis. In this study, we utilize...
Whole-brain efferent projections of glutamatergic neurons in the cingulate cortex of mice [0.03%]
小鼠扣带皮层谷氨酸能神经元的全脑投射_mappingiful
Fu Shi,Luyao Lei,Jiapeng Qiu et al.
Fu Shi et al.
The cingulate cortex, on the medial cerebral hemisphere, is involved in cognitive processing, emotional regulation, nociception, voluntary motor control, and sleep modulation. Anatomically, the cingulate cortex is organized into three disti...