Deficiency of SARM1 attenuates neuronal injury and improves neurological performance in a photothrombotic stroke model [0.03%]
SARM1不足可减轻光化学脑卒中模型中的神经元损伤并改善神经功能缺陷
Yanjie Huang,Xiaofeng Cheng,Ke Yan et al.
Yanjie Huang et al.
Stroke is a major cause of morbidity and mortality worldwide. There is an urgent need for effective neuroprotective agents to reduce brain injury. SARM1 (sterile alpha and TIR motif-containing 1) has been identified as a key mediator of axo...
Pharmacological inhibition of NaV1.8 by suzetrigine reveals potent analgesic potential without tolerance development in mice [0.03%]
药理学上通过苏泽特林抑制NaV1.8小鼠表现出强烈的止痛潜力且不会形成耐受性
Md Yousof Ali,Flavia T T Antunes,Sun Huang et al.
Md Yousof Ali et al.
The Voltage-gated sodium channel NaV1.8 is a critical determinant of nociceptive signaling in primary sensory neurons. Here, we evaluated the analgesic potential of suzetrigine, a potent clinically approved NaV1.8 blocker, using electrophys...
Septin5 deficiency impairs both recent and remote contextual fear memory [0.03%]
Septin5缺乏影响近期和远期情境恐惧记忆
Natsumi Ageta-Ishihara,Naoto Fukumasu,Kodai Sakakibara et al.
Natsumi Ageta-Ishihara et al.
Septin-3 and Septin-5 are components of the septin cytoskeleton highly expressed in the nervous system, yet the extent of their shared and distinct roles is not fully understood. We recently demonstrated that Septin-3 regulates late-phase l...
Cerebrolysin ameliorates ketamine-mediated anxiety and cognitive impairments via modulation of mitochondrial function and CREB/PGC-1α pathway [0.03%]
脑神经营养液通过调节线粒体功能和CREB/PGC-1α通路缓解氯胺酮介导的焦虑和认知障碍
Leila Hosseini,Nasrin Abolhasanpour,Fatemehsadat Seyedaghamiri et al.
Leila Hosseini et al.
Schizophrenia is known as a complex and devastating mental disorder due to its profound impact on individuals, families, and society. Emerging evidence proposes that mitochondria play a central role in schizophrenia. Here, we investigated w...
Abnormal behaviors and glial responses in an animal model of tau pathology [0.03%]
Tau病理动物模型中的异常行为和胶质细胞反应
Yue Liu,Akira Sobue,Naruhiko Sahara et al.
Yue Liu et al.
Tau hyperphosphorylation has been considered a major contributor to neurodegeneration in Alzheimer's disease (AD) and frontotemporal dementia, and related tauopathies have gained prominence in the development of therapies for these conditio...
Gpr176 modulates the firing pattern of parvalbumin-positive interneurons in the orbitofrontal cortex of mouse [0.03%]
Orbitofrontal皮层中的Gpr176调控parvalbumin阳性中间神经元的放电模式
Jing Tian,Ziran Huang,Wen Zhang
Jing Tian
Parvalbumin-positive (PV+) interneurons are the most abundant type of interneurons in the cortex. Its characteristic high-frequency non-accommodating firing pattern is critical for cortical inhibition, network activity, and mouse behavior. ...
Striatal transcriptomic alterations immediately after short-term abstinence from methamphetamine self-administration in rats [0.03%]
短期安非他明自给结束后大鼠纹状体转录组改变
Won-Jun Jang,Sang-Hoon Song,Taekwon Son et al.
Won-Jun Jang et al.
Substance use disorders, particularly drug addiction, are complex neurophysiological conditions characterized by cycles of compulsive drug use, withdrawal symptoms, and relapses. Methamphetamine (MA) addiction evolves through repeated expos...
PUS7-dependent Ψ reshapes specific synaptic gene exons to facilitate fear extinction memory formation [0.03%]
PUS7依赖的Ψ重塑特定的突触基因外显子以促进恐惧消退记忆的形成
Runming Liu,Yuhan Dong,Zhipeng Gao et al.
Runming Liu et al.
RNA modifications serve as dynamic regulators of neural plasticity through their ability to fine-tune transcript stability and splicing. Pseudouridine (Ψ), an evolutionarily conserved RNA modification catalyzed by pseudouridine synthases, ...
BDNF genotype associated with changes in cortical thickness, severity of symptoms, and cognitive impairments in mild traumatic brain injury [0.03%]
BDNF基因与轻度脑外伤相关的皮层厚度改变、症状严重程度和认知障碍的关系
Lei Shi,Yizhen Pan,Jie Yuan et al.
Lei Shi et al.
Objective: Brain-derived neurotrophic factor (BDNF) is a critical blood protein for brain function; however, its genotypic influence on clinical outcomes and brain structure following mild traumatic brain injury (mTBI) re...
Exploration of schizophrenia-related behavioral and molecular abnormalities in a mutant mouse model with a mutation in the TVV motif of the ErbB4 gene [0.03%]
携带ErbB4基因TVV基序突变的小鼠在行为学及分子生物学异常与精神分裂症的相关性研究
Abdul Aziz Khan,Shuai Wang,Ziying Wang et al.
Abdul Aziz Khan et al.
The ErbB4 gene is a schizophrenia (SCZ) risk gene that interacts with PSD-95 via its C-terminus, a connection disrupted in SCZ patients. To investigate the functional significance of this interaction, we generated a zygotic mutant mouse lac...