Generation of a new Slc20a2 knockout mouse line as in vivo model for primary brain calcification [0.03%]
生成Slc20a2敲除小鼠品系作为原发性脑钙化的体内模型
Hisaka Kurita,Hiroki Kitaura,Kazuya Nishii et al.
Hisaka Kurita et al.
Primary brain calcification (PBC) is a neurodegenerative disease that causes bilateral ectopic calcification in the brain. In this study, using newly generated Slc20a2 knockout (Slc20a2-/-) mice, we establish an in vivo model for PBC. In co...
Peripheral substance P induces deficits in hippocampal synaptic plasticity and memory [0.03%]
外周神经肽 Substance P 导致海马区突触可塑性和记忆力下降
Sun Yong Kim,Kyeong-No Yoon,Jungeun Ji et al.
Sun Yong Kim et al.
Substance P (SP) is a neuropeptide that functions in both the central and peripheral nervous systems. Although the peripheral actions of SP in regulating inflammatory responses have been extensively investigated, the effects of elevated per...
Neurodegeneration in Parkinson's disease: are we looking at the right spot? [0.03%]
帕金森病的神经退行性病变：我们是否关注了正确的部位？
Gabriel S Rocha,Marco Aurelio M Freire,Daniel Falcao et al.
Gabriel S Rocha et al.
Parkinson's disease (PD) is recognized as the fastest-growing neurodegenerative disorder, impacting millions of individuals worldwide. It is primarily characterized by cardinal motor symptoms, including bradykinesia (slowness of movement), ...
Correction to: Synergistic actions of corticosterone and BDNF on rat hippocampal LTP [0.03%]
Correction to：皮质酮和BDNF对大鼠海马长时程增强的协同作用
Jonathan S Thacker,Liam T Ralph,Laura Koek et al.
Jonathan S Thacker et al.
Published Erratum
Molecular brain. 2025 Jul 24;18(1):67. DOI:10.1186/s13041-025-01234-6 2025
Unraveling the mystery: How autophagy deficiency in dopaminergic neurons drives human Parkinson's disease [0.03%]
拨开迷雾：多巴胺能神经元自噬缺陷如何驱动帕金森病发病
Sachiko Noda,Nobutaka Hattori
Sachiko Noda
Alpha-synuclein (α-synuclein), a key component of Lewy body pathology, is a classical hallmark of Parkinson's disease. In previous studies, our group has examined dopaminergic neuron-specific Atg7 autophagy-deficient mice, observing α-syn...
Chronic oral administration of ibrutinib prevents long-term memory deficits and reduces AD pathology and neuroinflammatory responses in a mouse model of AD [0.03%]
伊布替尼慢性口服给药可预防阿尔兹海默病模型小鼠长期记忆缺失并减少病理损害及神经炎症反应
Hyun-Ju Lee,Sora Kang,Yoo Joo Jeong et al.
Hyun-Ju Lee et al.
We previously demonstrated that ibrutinib has therapeutic efficacy against AD pathologies when injected intraperitoneally at a lower dosage (10 mg/kg, daily for 2 weeks) or orally at a higher dosage (30 mg/kg, daily for 1 month) in AD mice ...
Differential effects of antiemetic serotonin receptor antagonist Ondansetron on nausea associated with CHRM3 rs2165870 and TACR1 rs3755468 single-nucleotide polymorphisms [0.03%]
选择性5-羟色胺受体拮抗剂止吐药奥坦西隆对胆碱能受体基因多态性恶心效应的影响研究
Yuna Kang,Seii Ohka,Daisuke Nishizawa et al.
Yuna Kang et al.
Postoperative nausea and vomiting (PONV) after orthognathic surgery is a serious postoperative complication. The cholinergic receptor muscarinic 3 (CHRM3) rs2165870 and tachykinin receptor 1 (TACR1) rs3755468 single-nucleotide polymorphisms...
The regulation of rhythmic locomotion by motor cortical and dopaminergic inputs in the mouse striatum [0.03%]
小鼠纹状体中运动皮质和多巴胺能输入对节律性运动调控的作用
Hua Zhang,Yunxiao Su,Xujun Wu et al.
Hua Zhang et al.
The striatum is a critical component of the basal ganglia and plays a central role in regulating motor initiation and action selection. How cortical and subcortical inputs converging at the striatum regulate locomotion remains unclear. By e...
Modulation of social valence by insular cortex activity during acute social isolation in mice [0.03%]
小鼠急性社会隔离期间内侧岛叶皮层活动对社会偏好的调节作用
Kanae Hiyoshi,Daichi Matsushita,Ayako M Watabe
Kanae Hiyoshi
For social animals, social isolation is a potential threat to survival, and therefore can be considered innately aversive. Long-term social isolation induces a variety of social and affective deficits and has been used as a stress model in ...
Deficiency of calretinin in prefrontal cortex causes behavioral deficits relevant to autism spectrum disorder in mice [0.03%]
小鼠前额叶钙网素缺陷导致与自闭症谱系障碍相关的行为异常
Yaodong Zhang,Xiaotong Zhao,Chao Gao et al.
Yaodong Zhang et al.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by core symptoms including deficits in social interaction, repetitive and stereotyped behaviors, along with higher levels of anxiety and cognitive impairments. Pr...