REST deficiency and neurogenic-to-gliogenic shift in down syndrome human cerebral organoids [0.03%]
唐氏综合征人脑类器官中REST功能缺乏与神经发生向胶质发生的转变
Tan Huang,Chong-Teik Lim,Wei Li et al.
Tan Huang et al.
Down syndrome (DS) features impaired cortical neurogenesis and excess gliogenesis, yet the temporal regulatory events driving this imbalance remain unclear. Here, we combine multi-timepoint transcriptomic analyses from publicly available da...
Modulation of BK-like potassium currents by ketamine in rat cochlear outer hair cells [0.03%]
氯胺酮对大鼠耳蜗外毛细胞BK样钾电流的调节作用
Xueying Yang,Yanan Lu,Xuerong Zhang et al.
Xueying Yang et al.
Ketamine is widely used as an anesthetic agent, yet its cellular effects on the auditory system, particularly on cochlear outer hair cells (OHCs), remain incompletely understood. In this study, we investigated the electrophysiological effec...
Jerry W Rudy
Jerry W Rudy
It has been 40 years since Francis Crick [1] noted the problem molecular turnover poses for maintaining memories and offered a general solution. The solution requires that the critical molecules must be replaced without altering the overall...
Soo-Kyeong Lee,Semin Park,Min-Young Yeom et al.
Soo-Kyeong Lee et al.
Cohen syndrome (CS) is a rare autosomal recessive neurodevelopmental disorder characterized by intellectual disability, microcephaly, retinal dystrophy, and neutropenia. We previously demonstrated that VPS13B mediates phosphatidylinositol 4...
An alternative inhibitory avoidance task for studying hippocampus-dependent spatial aversive memory in mice [0.03%]
一种用于研究小鼠海马体依赖的空间厌恶记忆的替代抑制回避任务
Haiyan Wang,Masanori Nomoto,Emi Murayama et al.
Haiyan Wang et al.
In natural environments, animals must navigate to goals while avoiding potential danger, making adaptive route choice crucial for survival. However, behavioral tasks for quantitatively evaluating avoidance through route choice during spatia...
Comprehensive protein synthesis inhibition impairs natural and artificial memory recall [0.03%]
蛋白质综合合成抑制损伤自然和人工记忆提取
Yeonjun Kim,Ilgang Hong,Bong-Kiun Kaang
Yeonjun Kim
Protein synthesis is critical for long-lasting memory formation and synaptic plasticity. However, whether protein synthesis is required for artificially evoked memory retrieval remains debated. To address this, we used a translation-inhibit...
Impaired phrenic nerve axon development and diaphragm neuromuscular junction formation in embryonic Cyfip2-null mice [0.03%]
胚胎Cyfip2基因敲除小鼠膈神经轴突发育和膈神经肌接头形成缺陷
Su Yeon Kim,Jun Young Oh,U Suk Kim et al.
Su Yeon Kim et al.
Pathogenic variants in CYFIP2 cause developmental and epileptic encephalopathy 65 (DEE65) and have been predominantly investigated in the context of central nervous system dysfunction. However, emerging clinical evidence suggests that perip...
Genome-wide mapping of stress-responsive lncRNA, uc.104, reveals the chromatin-mediated regulation of stress and plasticity-related genes in the hippocampus of chronic restraint rats [0.03%]
全基因组应激反应型长链非编码RNA uc.104 的图谱绘制揭示了慢性束缚大鼠海马中染色质介导的可塑性相关基因表达调控
Anuj K Verma,Bhaskar Roy,Kevin Prall et al.
Anuj K Verma et al.
Chronic stress significantly impacts hippocampal function through transcriptional and epigenetic mechanisms. While the roles of lncRNAs in stress-related transcriptional and epigenetic regulation have recently been recognized, their genome-...
Thalamic homeostatic transcriptomic signatures are altered in a mouse model of cholestatic liver injury and are mitigated by systemic TNF neutralization [0.03%]
肝胆管梗阻小鼠模型丘脑稳态转录组特征的改变可以通过全身性TNF中和得以缓解
Wagdi Almishri,Jeff F Dunn,Mark G Swain
Wagdi Almishri
Cholestatic liver diseases (CLD), including PBC and PSC, are frequently associated with debilitating sickness‑behavior symptoms such as fatigue, cognitive impairment, and anxiety/depression, which have poorly defined etiology and limited t...
Altered ECM deposition and cell adhesion signaling in a human cortical organoid model of fragile X syndrome [0.03%]
脆性X综合征的人类皮层器官模型中基质沉积和细胞粘附信号的改变
Sapir Havusha-Laufer,Venkat Raghavan Krishnaswamy,Noy Krugliak-Shechter et al.
Sapir Havusha-Laufer et al.
Fragile X Syndrome (FXS) is the most common inherited intellectual disability, and the most common monogenic cause of autism spectrum disorder (ASD). It is caused by epigenetic silencing of the FMR1 gene leading to the loss of FMRP, an RNA-...