Sleep transcends limited knowledge to support logical reward-related decisions in a novel task in male mice [0.03%]
睡眠通过超越有限的认知来支持小鼠在新颖的任务中做出逻辑的与奖赏相关的决定
Mostafa R Fayed,Khaled Ghandour,Ali Choucry et al.
Mostafa R Fayed et al.
Sleep is essential for strengthening memory and consolidation. Emerging evidence supports its role in cognitive processes such as rule abstraction and inference. However, how sleep influences logical nongambling probabilistic decision-makin...
Identification and validation of microglia-associated genes in ischemic stroke using single-cell and bulk RNA-seq [0.03%]
利用单细胞和批量RNA测序鉴定和验证缺血性卒中相关的微胶质细胞基因
Dongliang Qian,Shuangshuang Lu,Yuanyuan Hu et al.
Dongliang Qian et al.
Ischemic stroke (IS) is an acute cerebrovascular disease characterized by high incidence and mortality. The mechanism of microglia in the pathogenesis of IS remains unclear. This study aimed to explore the key genes related to microglia in ...
A cross-tissue transcriptome-wide association study identifies novel candidate genes associated with brain glymphatic system function [0.03%]
横跨组织的转录组关联研究确定了与大脑淋巴系统功能相关的新的候选基因
Xiaoyang Zhu,Shengjie Wang,Shuaiqi Zhang et al.
Xiaoyang Zhu et al.
The glymphatic system plays a key role in brain waste clearance, but its genetic regulation remains poorly understood. Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) index is a non-invasive imaging biomarker to asse...
Differential microglial responses to structurally distinct alpha-synuclein polymorphs [0.03%]
结构不同α-突触核蛋白多形体的微胶质细胞反应差异性分析
Katherine Chang,Jina Kim,Michiyo Iba et al.
Katherine Chang et al.
Synucleinopathies are age-related neurological disorders which include dementia with Lewy bodies (DLB), Parkinson's disease (PD), and multiple system atrophy (MSA). A hallmark of these diseases is the pathological accumulation of α-synucle...
AldoC BAC-GFP transgenic mice as a reliable model for astrocyte identification and functional studies in the brain [0.03%]
Aldoc-BAC-GFP转基因小鼠在脑星形胶质细胞识别及功能研究中的应用可靠模型
Juhyun Kim,Hayoung Yang,Seong Seop Kim et al.
Juhyun Kim et al.
Astrocytes, the most abundant glial cell type in the central nervous system (CNS), are essential for maintaining neural homeostasis, forming gliovascular unit, and modulating synaptic function. However, commonly used astrocytic markers ofte...
Aging-independent decrease of complex multi-spine boutons in hippocampal area CA1 after contextual fear conditioning [0.03%]
基于空间恐惧条件作用后海马CA1区复杂多棘突突触末端年龄独立性减少
Raquel Martinez-Serra,Suji Lee,Igor Kraev et al.
Raquel Martinez-Serra et al.
Long-lasting synaptic changes enable memory storage and regulate recall in the brain. Our previous work established that generation of multi-innervated dendritic spines (MISs), spines with typically two excitatory presynaptic inputs, underl...
Dysregulated circRNA-miRNA-mRNA networks reveal stage-specific mRNA expression changes in Parkinson's disease [0.03%]
环状circrna-mirna-mrna网络的失调揭示了帕金森病中阶段特异性mrna表达变化
Yulan Gao,Konii Takenaka,Kristina Santucci et al.
Yulan Gao et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by the loss of dopaminergic neurons and widespread transcriptomic dysregulation across disease stages. Patients commonly exhibit motor symptoms such as tremors, rig...
Adenylate kinase 5, a novel genetic risk factor for Alzheimer's disease, regulates microglial inflammatory activation [0.03%]
腺苷酸激酶5通过调节小胶质细胞炎症活化成为阿尔茨海默病的新型遗传风险因子
Won Jae Seong,Sang Joon An,Jungsoo Gim et al.
Won Jae Seong et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and neuroinflammation, primarily mediated by microglia. In this study, we investigate the role of adenylate kinase 5 (AK5)...
Molecular mechanisms of gut microbiota dysbiosis and metabolites in Alzheimer's disease pathogenesis: implications for precision therapeutics [0.03%]
肠道微生物群失调及其代谢物在阿尔茨海默病发病机制中的分子机理：精准治疗的启示
Yashar Vaziri,Jaleh Bagheri Hamzyan Olia,Cigir Biray Avci et al.
Yashar Vaziri et al.
Alzheimer's disease (AD) originates from both central and peripheral pathways. The gut microbiota is a clear risk factor. In AD, microbiota imbalances drive immune system activation, disrupt protective barriers, and alter neuromodulatory si...
Perineuronal nets in the developing brain: implications for neurodevelopmental disorders [0.03%]
发育性脑病态神经节苷脂：对神经发育障碍的意义
Jennifer M Ackerman,Thomas James L Ford,Shraddha Shridhar Kattewar et al.
Jennifer M Ackerman et al.
Here, we review recent findings on the development, functions, and alterations of perineuronal nets (PNNs) in relation to neurodevelopmental pathologies. PNNs are dense extracellular matrix structures primarily found in the central nervous ...