PAK1 expression protects cellular and behavioral defects in animal models of Parkinson' s disease [0.03%]
PAK1表达保护帕金森病动物模型的细胞和行为缺陷
Jeong Eun Kim,Kina Lee,Hee Jeong Kim et al.
Jeong Eun Kim et al.
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder worldwide. Although various therapeutics have been developed, no disease-modifying treatment has been established to date. Recent studies highlight critical ro...
Diabetes reprograms brain and systemic immune landscapes to impair repair after injury [0.03%]
糖尿病重塑脑部和全身免疫图谱以在损伤后抑制修复功能
Keon Ah Lee,Su Yeon Kim,Jin Soo Lee et al.
Keon Ah Lee et al.
Diabetes is a major risk factor for poor outcomes following brain injury, yet the underlying mechanisms remain incompletely understood. Using stereotaxic ATP injection into the striatum combined with 9.4T MRI, we found that diabetic mice ex...
Leveraging single-cell and spatial omics for brain tumour insights to improve therapeutic strategies [0.03%]
利用单细胞和空间组学技术深入解析脑肿瘤以改善治疗策略
Subham Roy,Maher Nassor,Fahmida Zahin et al.
Subham Roy et al.
Single-cell and spatial omics (SPOs) technologies have advanced how healthcare physicians characterise brain tumours by enabling detailed understanding of their cellular architecture, functional states, and microenvironmental dynamics. Thes...
The CDK4/6 inhibitor abemaciclib attenuates cognitive impairment and neuroinflammation via DYRK1A in human tau transgenic mice [0.03%]
CDK4/6抑制剂abemaciclib通过DYRK1A缓解tau转基因小鼠的认知障碍和神经炎症
Hyun-Ju Lee,Hyang-Sook Hoe
Hyun-Ju Lee
We recently demonstrated that abemaciclib treatment modulates cognitive function, Alzheimer's disease (AD) pathology, and neuroinflammatory responses in wild-type mice treated with lipopolysaccharide and in 5xFAD mice. In this study, we inv...
Subham Roy,Fahmida Zahin,Princess Afia Nkrumah-Boateng et al.
Subham Roy et al.
Tumour organoids have emerged as important tools in brain tumour research, addressing long-standing limitations of conventional two-dimensional cultures, xenograft models, and genetically engineered mouse models. By preserving patient-speci...
Blocking estrogen receptors restores surface mGluR5 but not downstream signaling in female APP/PS1 Mice [0.03%]
雌性APP/PS1小鼠中阻断雌激素受体可恢复表面mGluR5但不能恢复下游信号通路
Karim S Ibrahim,Awatif Albaker,Khaled S Abd-Elrahman et al.
Karim S Ibrahim et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that disproportionately affects women. Deposition of β-amyloid (Aβ), a hallmark of AD pathology, disrupts metabotropic glutamate receptor-5 (mGluR5) regulation of autoph...
Npas4 regulates synaptic development in the patch/striosome compartment and early affective vocalization in neonatal mice [0.03%]
Npas4调节小鼠补体/纹状回隔区突触发育及产后早期情感性发声
Yen-Hui Lee,Hsiao-Ying Kuo,Shih-Yun Chen et al.
Yen-Hui Lee et al.
Early vocal communication, such as isolation-induced ultrasonic vocalization (USV) in neonatal rodents, is critical for infant survival and represents a primary readout of early affective states. The patch/striosome compartment in the stria...
Environmental enrichment is associated with enhanced novel object recognition performance and an increased proportion of smooth endoplasmic reticulum-containing spines in the dentate gyrus of Septin3-/- mice [0.03%]
环境丰富与Septin3基因敲除小鼠海马齿状回平滑内质网型突起比例增加及新物体识别能力增强有关
Natsumi Ageta-Ishihara,Naoki Fuse,Ayako Suzuki et al.
Natsumi Ageta-Ishihara et al.
Septin-3 is a neuron-enriched member of the septin family, a group of GTP-binding cytoskeletal proteins. We previously reported that Septin-3 supports late-phase long-term potentiation (L-LTP)-induced entry of smooth endoplasmic reticulum (...
Sevoflurane ameliorates cerebral ischemia-reperfusion injury by modulating mitochondrial dynamics and attenuating apoptosis via Shh-YAP1 signaling pathway [0.03%]
异氟烷通过调节线粒体动态学及激活Shh-YAP1信号通路抑制凋亡来改善脑缺血再灌注损伤
Li Peng,Mengmeng Yang,Jiayuan Liu et al.
Li Peng et al.
Ischemia-reperfusion injury (IRI) is a critical issue in the prevention and treatment of ischemic stroke. Inhalational anesthetics have been proven to have neuroprotective effects and sevoflurane is currently the most commonly used inhaled ...
Tbx1 heterozygosity in the oligodendrocyte lineage shifts myelinated axon composition in the mouse fimbria without behavioral impairments [0.03%]
Tbx1单倍体不足会影响少突胶质细胞系中鼠脑颞叶联合束的髓鞘轴索组成而不会影响行为反应
Anne Marie Wells,Takaki Tanifuji,Takeshi Takano et al.
Anne Marie Wells et al.
Constitutive heterozygosity of Tbx1, a T-box transcription factor gene located within the 22q11.2 deletion region, results in behavioral deficits and altered composition of myelinated axons in the fimbria, together with reduced levels of an...