The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases [0.03%]
基于细胞的精准医疗拦截计划（37TrillionCells倡议）及其在神经退行性疾病中的应用重点改善全球卫生
Benoit Coulombe,Thomas M Durcan,Geneviève Bernard et al.
Benoit Coulombe et al.
One of the main burdens in the treatment of diseases is imputable to the delay between the appearance of molecular dysfunctions in the first affected disease cells and their presence in sufficient number for detection in specific tissues or...
Synaptopodin is required for long-term depression at Schaffer collateral-CA1 synapses [0.03%]
突触蛋白对Schaffer collaterals-CA1突触的长时程抑制是必需的
Yanis Inglebert,Pei You Wu,Julia Tourbina-Kolomiets et al.
Yanis Inglebert et al.
Synaptopodin (SP), an actin-associated protein found in telencephalic neurons, affects activity-dependant synaptic plasticity and dynamic changes of dendritic spines. While being required for long-term depression (LTD) mediated by metabotro...
Differential contribution of canonical and noncanonical NLGN3 pathways to early social development and memory performance [0.03%]
经典和非经典NLGN3通路对早期社交发展和记忆表现的差异化贡献
Lin-Yu Li,Ayako Imai,Hironori Izumi et al.
Lin-Yu Li et al.
Neuroligin (NLGN) 3 is a postsynaptic cell adhesion protein organizing synapse formation through two different types of transsynaptic interactions, canonical interaction with neurexins (NRXNs) and a recently identified noncanonical interact...
Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation [0.03%]
突变的α-突触核蛋白通过激活ERK1/2和JNK导致人类皮层神经元死亡
Hidefumi Suzuki,Naohiro Egawa,Keiko Imamura et al.
Hidefumi Suzuki et al.
Synucleinopathies refer to a group of disorders characterized by SNCA/α-synuclein (α-Syn)-containing cytoplasmic inclusions and neuronal cell loss in the nervous system including the cortex, a common feature being cognitive impairment. St...
Maxinne Watchon,Amanda L Wright,Holly I Ahel et al.
Maxinne Watchon et al.
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is a fatal neurodegenerative disease that causes loss of balance and motor co-ordination, eventually leading to paralysis. It is caused by the autosomal dominant inh...
Crucial role of TFAP2B in the nervous system for regulating NREM sleep [0.03%]
TFAP2B在调节非快速眼动睡眠的神经系统中的关键作用
Ayaka Nakai,Mitsuaki Kashiwagi,Tomoyuki Fujiyama et al.
Ayaka Nakai et al.
The AP-2 transcription factors are crucial for regulating sleep in both vertebrate and invertebrate animals. In mice, loss of function of the transcription factor AP-2β (TFAP2B) reduces non-rapid eye movement (NREM) sleep. When and where T...
TREM2 improves microglia function and synaptic development in autism spectrum disorders by regulating P38 MAPK signaling pathway [0.03%]
TREM2通过调节P38MAPK信号通路改善自闭症谱系障碍中的小胶质细胞功能和突触发育
Yi Tian,Xiao Xiao,Weiliang Liu et al.
Yi Tian et al.
Background: Autism spectrum disorder (ASD) encompasses a diverse range of neurodevelopmental disorders, but the precise underlying pathogenesis remains elusive. This study aim to explore the potential mechanism of TREM2 i...
Selective enhancement of fear extinction by inhibiting neuronal adenylyl cyclase 1 (AC1) in aged mice [0.03%]
通过抑制年老小鼠的神经腺苷酸环化酶1（AC1）选择性增强恐惧消退
Wantong Shi,Qi-Yu Chen,Yujie Ma et al.
Wantong Shi et al.
Adenylyl cyclase 1 (AC1) is a selective subtype of ACs, which is selectively expressed in neurons. The activation of AC1 is activity-dependent, and AC1 plays an important role in cortical excitation that contributes to chronic pain and rela...
A simple and reliable method for claustrum localization across age in mice [0.03%]
一种简单可靠的小鼠不同年龄oclaustrum定位方法
Tarek Shaker,Gwyneth J Dagpa,Vanessa Cattaud et al.
Tarek Shaker et al.
The anatomical organization of the rodent claustrum remains obscure due to lack of clear borders that distinguish it from neighboring forebrain structures. Defining what constitutes the claustrum is imperative for elucidating its functions....
In vitro modulation of mTOR and mGlur5 influence α-synuclein accumulation [0.03%]
mTOR和mGlur5的体外调节影响α-突触核蛋白的聚集
Viktoria Xing,Kyle Biggar,Stephen S G Ferguson et al.
Viktoria Xing et al.
One of the main hallmarks of Parkinson's disease (PD) is abnormal alpha-synuclein (α-syn) aggregation which forms the main component of intracellular Lewy body inclusions. This short report used preformed α-syn fibrils, as well as an A53T...