A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy [0.03%]
一种新颖的小鼠模型用于研究 oliogodndrocytes 中的α-突触核蛋白聚集体：多系统萎缩中胶质细胞胞浆包涵体的意义
Tomoyuki Ishimoto,Miki Oono,Seiji Kaji et al.
Tomoyuki Ishimoto et al.
The aggregated alpha-synuclein (αsyn) in oligodendrocytes (OLGs) is one of the pathological hallmarks in multiple system atrophy (MSA). We have previously reported that αsyn accumulates not only in neurons but also in OLGs long after the ...
Region-specific activation in the accumbens nucleus by itch with modified scratch efficacy in mice - a model-free multivariate analysis [0.03%]
小鼠全向活化阿肯巴赫核的瘙痒模型的区域特异性激活-具有修改后的抓挠效力的无模型多变量分析
Sanae Inokuchi-Sakata,Ryo Narita,Yukari Takahashi et al.
Sanae Inokuchi-Sakata et al.
Itch is a protective/defensive function with divalent motivational drives. Itch itself elicits an unpleasant experience, which triggers the urge to scratch, relieving the itchiness. Still, it can also result in dissatisfaction when the scra...
Broad proteomics analysis of seeding-induced aggregation of α-synuclein in M83 neurons reveals remodeling of proteostasis mechanisms that might contribute to Parkinson's disease pathogenesis [0.03%]
博型诱导的α-突触核蛋白在M83神经元中的聚集的广泛蛋白质组分析揭示了可能有助于帕金森病发病机制的稳态重塑机制
Casey J Lumpkin,Hiral Patel,Gregory K Potts et al.
Casey J Lumpkin et al.
Aggregation of misfolded α-synuclein (α-syn) is a key characteristic feature of Parkinson's disease (PD) and related synucleinopathies. The nature of these aggregates and their contribution to cellular dysfunction is still not clearly elu...
A method for selective and efficient isolation of gray matter astrocytes from the spinal cord of adult mice [0.03%]
从小鼠脊髓中选择性和高效性分离星形胶质细胞的方法
Ryoma Iwasaki,Yuta Kohro,Makoto Tsuda
Ryoma Iwasaki
A growing body of evidence indicates intra- and inter-regional heterogeneity of astrocytes in the brain. However, because of a lack of an efficient method for isolating astrocytes from the spinal cord, little is known about how much spinal ...
Spatiotemporal dynamics of the CD11c+ microglial population in the mouse brain and spinal cord from developmental to adult stages [0.03%]
小鼠脑和脊髓中CD11c+微胶质细胞群从发育到成年阶段的时空动态变化规律
Kohei Nomaki,Risako Fujikawa,Takahiro Masuda et al.
Kohei Nomaki et al.
CD11c-positive (CD11c+) microglia have attracted considerable attention because of their potential implications in central nervous system (CNS) development, homeostasis, and disease. However, the spatiotemporal dynamics of the proportion of...
Moxibustion ameliorates chronic inflammatory visceral pain via spinal circRNA-miRNA-mRNA networks: a central mechanism study [0.03%]
温针改善慢性内脏炎症性疼痛的脊髓circRNA-miRNA-mRNA调控网络中枢机制研究
Dan Zhang,Xiaoqing Dong,Xiaoying Li et al.
Dan Zhang et al.
This study aimed to unveil the central mechanism of moxibustion treating chronic inflammatory visceral pain (CIVP) from the angle of circRNA-miRNA-mRNA networks in the spinal cord. The rat CIVP model was established using a mixture of 5% (w...
Chronic pain enhances excitability of corticotropin-releasing factor-expressing neurons in the oval part of the bed nucleus of the stria terminalis [0.03%]
慢性疼痛增强终纹床核卵圆部催产素释放神经元的兴奋性
Ryoko Uchida,Yasutaka Mukai,Taiju Amano et al.
Ryoko Uchida et al.
We previously reported that enhanced corticotropin-releasing factor (CRF) signaling in the bed nucleus of the stria terminalis (BNST) caused the aversive responses during acute pain and suppressed the brain reward system during chronic pain...
L-DOPA regulates neuroinflammation and Aβ pathology through NEP and ADAM17 in a mouse model of AD [0.03%]
左旋多巴通过神经肽酶和ADAM17调节神经系统炎症和阿尔茨海默病小鼠模型中的淀粉样蛋白病理学
Hyun-Ju Lee,JinHan Nam,Jeong-Woo Hwang et al.
Hyun-Ju Lee et al.
Dopamine plays important roles in cognitive function and inflammation and therefore is involved in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). Drugs that increase or maintain dopamine levels in the br...
Peripheral-central network analysis of cancer cachexia status accompanied by the polarization of hypothalamic microglia with low expression of inhibitory immune checkpoint receptors [0.03%]
外周-中心网络分析癌症恶病质伴下丘脑小胶质细胞去极化及抑制性免疫检查点受体低表达状态
Yukari Suda,Keiko Nakamura,Fukiko Matsuyama et al.
Yukari Suda et al.
While the excessive inflammation in cancer cachexia is well-known to be induced by the overproduction of inflammatory mediators in the periphery, microflora disruption and brain dysfunction are also considered to contribute to the induction...
Correction to: Toll-like receptor 4 deficiency ameliorates β2-microglobulin induced age-related cognition decline due to neuroinflammation in mice [0.03%]
TLR4缺陷通过抑制神经炎症缓解小鼠β2微球蛋白致衰老相关认知障碍的纠正通告
Qi Zhong,Yufeng Zou,Hongchao Liu et al.
Qi Zhong et al.
Published Erratum
Molecular brain. 2024 Apr 23;17(1):19. DOI:10.1186/s13041-024-01090-w 2024