Ge Feng,Zongkai Wu,Leyi Yang et al.
Ge Feng et al.
Stroke is a significant global burden, causing extensive morbidity and mortality. In metabolic states where glucose is limited, ketone bodies, predominantly β-hydroxybutyrate (BHB), act as alternative fuel sources. Elevated levels of BHB h...
Systemic inflammation attenuates the repair of damaged brains through reduced phagocytic activity of monocytes infiltrating the brain [0.03%]
系统性炎症通过降低浸润到脑中的单核细胞的吞噬活性来削弱受损脑组织的修复功能
Sushil Gaire,Jiawei An,Haijie Yang et al.
Sushil Gaire et al.
In this study, we examined how systemic inflammation affects repair of brain injury. To this end, we created a brain-injury model by stereotaxic injection of ATP, a damage-associated molecular pattern component, into the striatum of mice. S...
Spared nerve injury leads to reduced activity of neurons projecting from the ventrolateral periaqueductal gray to the locus coeruleus [0.03%]
坐侧导水管周围灰质-蓝斑投射神经元在 spared nerve injury 后活性降低
Wing Lam Yu,Zizhen Zhang,Gerald W Zamponi
Wing Lam Yu
The ventrolateral periaqueductal gray (vlPAG) serves as a central hub for descending pain modulation. It receives upstream projections from the medial prefrontal cortex (mPFC) and the ventrolateral orbitofrontal cortex (vlOFC), and projects...
The myelin water imaging transcriptome: myelin water fraction regionally varies with oligodendrocyte-specific gene expression [0.03%]
髓鞘水成像转录组：髓鞘水分数与少突胶质细胞特异性基因表达区域性变化有关
Jaimie J Lee,Paulina S Scheuren,Hanwen Liu et al.
Jaimie J Lee et al.
Identifying sensitive and specific measures that can quantify myelin are instrumental in characterizing microstructural changes in neurological conditions. Neuroimaging transcriptomics is emerging as a valuable technique in this regard, off...
The duality of amyloid-β: its role in normal and Alzheimer's disease states [0.03%]
淀粉样蛋白-β的双重性：其在正常和阿尔茨海默病状态下的作用
Ali Azargoonjahromi
Ali Azargoonjahromi
Alzheimer's disease (AD) is a degenerative neurological condition that gradually impairs cognitive abilities, disrupts memory retention, and impedes daily functioning by impacting the cells of the brain. A key characteristic of AD is the ac...
The overexpression of DSP1 in neurons induces neuronal dysfunction and neurodegeneration phenotypes in Drosophila [0.03%]
DSP1在神经元中的过表达诱导果蝇的神经元功能障碍和神经退行性病变表型
Si-Eun Baek,Younghwi Kwon,Jong-Won Yoon et al.
Si-Eun Baek et al.
Dorsal switch protein 1(DSP1), a mammalian homolog of HMGB1, is firstly identified as a dorsal co-repressor in 1994. DSP1 contains HMG-box domain and functions as a transcriptional regulator in Drosophila melanogaster. It plays a crucial ro...
MicroRNAs as the pivotal regulators of Temozolomide resistance in glioblastoma [0.03%]
微小核糖核酸调控胶质母细胞瘤替莫唑胺耐药性的研究进展
Mahsa Palizkaran Yazdi,Amirhosein Barjasteh,Meysam Moghbeli
Mahsa Palizkaran Yazdi
Glioblastoma (GBM) is an aggressive nervous system tumor with a poor prognosis. Although, surgery, radiation therapy, and chemotherapy are the current standard protocol for GBM patients, there is still a poor prognosis in these patients. Te...
Cerebellar damage with inflammation upregulates oxytocin receptor expression in Bergmann Glia [0.03%]
小脑损伤伴炎症可上调Bergman胶质细胞催产素受体表达
Ayumu Inutsuka,Aisa Hattori,Masahide Yoshida et al.
Ayumu Inutsuka et al.
The cerebellum plays an important role in cognitive and social functioning. Childhood damage in the cerebellum increases the risk of autism spectrum disorder. Cerebellar inflammation induces social avoidance in mice. Oxytocin regulates soci...
Long-read RNA sequencing identifies region- and sex-specific C57BL/6J mouse brain mRNA isoform expression and usage [0.03%]
长读RNA测序识别C57BL/6J小鼠大脑mRNA转录本表达及应用的区域和性别特异性
Emma F Jones,Timothy C Howton,Victoria L Flanary et al.
Emma F Jones et al.
Alternative splicing (AS) contributes to the biological heterogeneity between species, sexes, tissues, and cell types. Many diseases are either caused by alterations in AS or by alterations to AS. Therefore, measuring AS accurately and effi...
Inhibition of cortical synaptic transmission, behavioral nociceptive, and anxiodepressive-like responses by arecoline in adult mice [0.03%]
槟榔碱对小鼠皮层突触传递和痛觉以及类似抗抑郁作用的抑制效应
Qi-Yu Chen,Yuxiang Zhang,Yujie Ma et al.
Qi-Yu Chen et al.
Areca nut, the seed of Areca catechu L., is one of the most widely consumed addictive substances in the world after nicotine, ethanol, and caffeine. The major effective constituent of A. catechu, arecoline, has been reported to affect the c...