Protocadherin 19 regulates axon guidance in the developing Xenopus retinotectal pathway [0.03%]
原钙粘蛋白19通过调节发育中的非洲爪蟾视网膜至视顶盖通路的轴突导向来调控视图轨迹形成
Jane Jung,Jugeon Park,Sihyeon Park et al.
Jane Jung et al.
Protocadherin 19 (Pcdh19) is a homophilic cell adhesion molecule and is involved in a variety of neuronal functions. Here, we tested whether Pcdh19 has a regulatory role in axon guidance using the developing Xenopus retinotectal system. We ...
Comprehensive identification of ubiquitin-like 3 (UBL3)-interacting proteins in the mouse brain [0.03%]
鼠脑中识别泛素样3(UBL3)相互作用蛋白的全面鉴定
Hiroshi Ageta,Tomoki Nishioka,Hisateru Yamaguchi et al.
Hiroshi Ageta et al.
Discovery of novel post-translational modifications provides new insights into changes in protein function, localization, and stability. They are also key elements in understanding disease mechanisms and developing therapeutic strategies. W...
Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson's disease [0.03%]
少突胶质细胞和前体细胞的转录组变化与帕金森病的临床结果相关
Mohammad Dehestani,Velina Kozareva,Cornelis Blauwendraat et al.
Mohammad Dehestani et al.
Several prior studies have proposed the involvement of various brain regions and cell types in Parkinson's disease (PD) pathology. Here, we performed snRNA-seq on the prefrontal cortex and anterior cingulate regions from a small cohort of p...
Database-assisted screening of autism spectrum disorder related gene set [0.03%]
基于数据库的自闭症光谱系相关基因筛选分析
Éva Kereszturi
Éva Kereszturi
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social and communication difficulties, along with repetitive behaviors. While genetic factors play a significant role in ASD, the precise genetic landscape re...
Determinants of interactions of a novel next-generation gabapentinoid NVA1309 and mirogabalin with the Cavα2δ-1 subunit [0.03%]
新型第二代加巴喷丁类药物NVA1309和米那环素与Cavα2δ-1亚基相互作用的决定因素
Ivana A Souza,Maria A Gandini,Md Yousof Ali et al.
Ivana A Souza et al.
NVA1309 is a non-brain penetrant next-generation gabapentinoid shown to bind Cavα2δ at R243 within a triple Arginine motif forming the binding site for gabapentin and pregabalin. In this study we have compared the effects of NVA1309 with ...
Ying Su,Aimei Liu,Hongguang Chen et al.
Ying Su et al.
Human embryonic stem cells and human induced pluripotent stem cells may be used to create 3D tissues called brain organoids. They duplicate the physiological and pathological characteristics of human brain tissue more faithfully in terms of...
Takashi Ogino,Masakazu Agetsuma,Masato Sawada et al.
Takashi Ogino et al.
Activation of astrocytes after sensory stimulation has been reported to be involved in increased blood flow in the central nervous system. In the present study, using a chemogenetic method to induce astrocyte activation in mice without sens...
Involvement of posterior hypothalamic CaMKII-positive neurons in ADHD-like behaviors in mice [0.03%]
小鼠后下丘脑CaMKII阳性神经元参与多动症样行为
Changwoo Lee,Changsu Woo,Gyeong Ryeong Ma et al.
Changwoo Lee et al.
This study explores the behavioral effects of modulating CaMKII-positive (CaMKII+) neurons in the posterior hypothalamus (PH). Utilizing a chemogenetic approach in mice, we discovered that the activation of CaMKII + neurons within the PH is...
Intraplantar aminoglutethimide, a P450scc inhibitor, reduced the induction of mechanical allodynia in a rat model of thrombus-induced ischemic pain [0.03%]
足底给药抗肾上腺皮质激素药物氨基葡萄糖醛亚胺(P450scc抑制剂)可减少血栓诱导的缺血性疼痛模型大鼠机械痛觉过敏的产生
Soon-Gu Kwon,Hoon-Seong Choi,Seo-Yeon Yoon et al.
Soon-Gu Kwon et al.
Neuroactive steroids (NASs) directly affect neuronal excitability. Despite their role in the nervous system is intimately linked to pain control, knowledge is currently limited. This study investigates the peripheral involvement of NASs in ...
Neurexin-3 in the paraventricular nucleus of the hypothalamus regulates body weight and glucose homeostasis independently of food intake [0.03%]
下丘脑室旁核神经突触蛋白-3通过独立于摄食量的机制调节体重和糖代谢
Mingdao Mu,Haoyu Sun,Shuyan Geng et al.
Mingdao Mu et al.
Neurexin-3 (Nrxn3) has been genetically associated with obesity, but the underlying neural mechanisms remain poorly understood. This study aimed to investigate the role of Nrxn3 in the paraventricular nucleus of the hypothalamus (PVN) in re...