Acute stress enhances the glutamatergic transmission onto basoamygdala neurons embedded in distinct microcircuits [0.03%]
急性压力增强初级中央杏仁核不同微环路神经元的谷氨酸能传递
Chen Song,Wen-Hua Zhang,Xue-Hui Wang et al.
Chen Song et al.
Amygdala activation is known to be critical for the processing of stressful events in brain. Recent studies have shown that the projection neurons (PNs) in amygdala, although architecturally intermingled, are integrated into distinct microc...
Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging [0.03%]
间歇性缺氧的治疗通过与衰老共有的生物过程增加海马体中磷酸化tau蛋白含量
Sosuke Yagishita,Seiya Suzuki,Keisuke Yoshikawa et al.
Sosuke Yagishita et al.
Sleep-disordered breathing produces cognitive impairments, and is possibly associated with Alzheimer disease (AD). Intermittent hypoxia treatment (IHT), an experimental model for sleep-disordered breathing, results in cognitive impairments ...
Tat-HSP22 inhibits oxidative stress-induced hippocampal neuronal cell death by regulation of the mitochondrial pathway [0.03%]
Tat-HSP22通过调节线粒体途径抑制氧化应激诱导的海马神经元细胞死亡
Hyo Sang Jo,Dae Won Kim,Min Jea Shin et al.
Hyo Sang Jo et al.
Oxidative stress plays an important role in the progression of various neuronal diseases including ischemia. Heat shock protein 22 (HSP22) is known to protect cells against oxidative stress. However, the protective effects and mechanisms of...
The thalamic mGluR1-PLCβ4 pathway is critical in sleep architecture [0.03%]
背侧丘脑mGluR1-PLCβ4信号通路在调控睡眠结构中起关键作用
Joohyeon Hong,Jungryun Lee,Kiyeong Song et al.
Joohyeon Hong et al.
The transition from wakefulness to a nonrapid eye movement (NREM) sleep state at the onset of sleep involves a transition from low-voltage, high-frequency irregular electroencephalography (EEG) waveforms to large-amplitude, low-frequency EE...
The anti-inflammatory role of extranuclear apurinic/apyrimidinic endonuclease 1/redox effector factor-1 in reactive astrocytes [0.03%]
细胞外核脱嘌呤/脱嘧啶内切酶1/红氧效应因子-1在反应性星形胶质细胞中的抗炎作用
Hyunjung Baek,Chae Seong Lim,Hee Sun Byun et al.
Hyunjung Baek et al.
Apurinic/apyrimidinic endonuclease 1 (APE1), a ubiquitous multipurpose protein, is also known as redox effector factor-1 (Ref-1). It is involved in DNA repair and redox signaling and, in turn, oxidative stress-induced neurodegeneration. Alt...
Expression of acid-sensing ion channels and selection of reference genes in mouse and naked mole rat [0.03%]
酸感受离子通道的表达及裸鼹鼠和小鼠参考基因的选择
Laura-Nadine Schuhmacher,Ewan St John Smith
Laura-Nadine Schuhmacher
Acid-sensing ion channels (ASICs) are a family of ion channels comprised of six subunits encoded by four genes and they are expressed throughout the peripheral and central nervous systems. ASICs have been implicated in a wide range of physi...
Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice [0.03%]
早期感觉剥夺引起的社交记忆缺陷与催产素有关
Jin-Bao Zhang,Ling Chen,Zhu-Man Lv et al.
Jin-Bao Zhang et al.
Early-life sensory input plays a crucial role in brain development. Although deprivation of orofacial sensory input at perinatal stages disrupts the establishment of the barrel cortex and relevant callosal connections, its long-term effect ...
Shigeki Ohta,Tomonori Yaguchi,Hironobu Okuno et al.
Shigeki Ohta et al.
Macrophage migration inhibitory factor (MIF) plays an important role in supporting the proliferation and/or survival of murine neural stem/progenitor cells (NSPCs); however, the downstream effectors of this factor remain unknown. Here, we s...
Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT2C receptor mediated appetite [0.03%]
普瑞德威利症候群小鼠模型中Htr2c的替代剪接增加会导致5-羟色胺2C受体介导摄食行为的异常
Alastair S Garfield,Jennifer R Davies,Luke K Burke et al.
Alastair S Garfield et al.
Alternate splicing of serotonin (5-hydroxytryptamine; 5-HT) 2C receptor (5-HT2CR) pre-RNA is negatively regulated by the small nucleolar RNA, Snord115, loss of which is observed in nearly all individuals with Prader-Willi Syndrome (PWS), a ...
Heantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing [0.03%]
一种用于治疗药物成瘾的天然植物萃取物Heantos-4调节T型钙通道和丘脑皮层簇状放电
Stuart M Cain,Soyon Ahn,Esperanza Garcia et al.
Stuart M Cain et al.
Heantos-4 is a refined combination of plant extracts currently approved to treat opiate addiction in Vietnam. In addition to its beneficial effects on withdrawal and prevention of relapse, reports of sedation during clinical treatment sugge...