In vivo whole-cell recording with high success rate in anaesthetized and awake mammalian brains [0.03%]
高成功率麻醉和清醒哺乳动物大脑中的在体全细胞记录技术
Yao Wang,Yu-Zhang Liu,Shi-Yi Wang et al.
Yao Wang et al.
As a critical technique for dissection of synaptic and cellular mechanisms, whole-cell patch-clamp recording has become feasible for in vivo preparations including both anaesthetized and awake mammalian brains. However, compared with in vit...
Pathological classification of human iPSC-derived neural stem/progenitor cells towards safety assessment of transplantation therapy for CNS diseases [0.03%]
人诱导多能干细胞来源神经细胞病理分类向中枢神经系统疾病移植治疗安全性评估发展
Keiko Sugai,Ryuji Fukuzawa,Tomoko Shofuda et al.
Keiko Sugai et al.
The risk of tumorigenicity is a hurdle for regenerative medicine using induced pluripotent stem cells (iPSCs). Although teratoma formation is readily distinguishable, the malignant transformation of iPSC derivatives has not been clearly def...
Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementias [0.03%]
collapsin反应介质蛋白-2的第514位苏氨酸磷酸化增加与路易体痴呆症中的β淀粉样蛋白沉积和突触缺陷相关
Huayang Xing,Yun-An Lim,Joyce R Chong et al.
Huayang Xing et al.
Collapsin response mediator protein-2 (CRMP2) regulates axonal growth cone extension, and increased CRMP2 phosphorylation may lead to axonal degeneration. Axonal and synaptic pathology is an important feature of Lewy body dementias (LBD), b...
Nuclear organization and 3D chromatin architecture in cognition and neuropsychiatric disorders [0.03%]
核组织和三维染色质结构在认知和神经精神疾病中的作用
Alejandro Medrano-Fernández,Angel Barco
Alejandro Medrano-Fernández
The current view of neuroplasticity depicts the changes in the strength and number of synaptic connections as the main physical substrate for behavioral adaptation to new experiences in a changing environment. Although transcriptional regul...
Visual and noxious electrical stimulus-evoked membrane-potential responses in anterior cingulate cortical neurons [0.03%]
背侧前扣带回皮层神经元的视觉和电刺激诱发反应特性研究
Li-Qing Ma,Li Ning,Zhiru Wang et al.
Li-Qing Ma et al.
Anterior cingulate cortex (ACC) is known to participate in numerous brain functions, such as memory storage, emotion, attention, as well as perception of acute and chronic pain. ACC-dependent brain functions often rely on ACC processing of ...
Hypothermia inhibits the propagation of acute ischemic injury by inhibiting HMGB1 [0.03%]
低温通过抑制HMGB1的释放而阻止急性缺血再灌注损伤的进行
Jung Ho Lee,Eun Jang Yoon,Jeho Seo et al.
Jung Ho Lee et al.
Acute ischemic stroke causes significant chronic disability worldwide. We designed this study to clarify the mechanism by which hypothermia helps alleviate acute ischemic stroke. In a middle cerebral artery occlusion model (4 h ischemia wit...
Edleusa M L Batista,Juliana G Doria,Talita H Ferreira-Vieira et al.
Edleusa M L Batista et al.
The metabotropic glutamate receptor 5 (mGluR5) and the cannabinoid receptor 1 (CB1) exhibit a functional interaction, as CB1 regulates pre-synaptic glutamate release and mGluR5 activation increases endocannabinoid synthesis at the post-syna...
Amyloid β oligomers elicit mitochondrial transport defects and fragmentation in a time-dependent and pathway-specific manner [0.03%]
β淀粉样蛋白寡聚体以时间依赖性和途径特异性方式诱发线粒体运输缺陷和碎裂现象
Yanfang Rui,James Q Zheng
Yanfang Rui
Small oligomeric forms of amyloid-β (Aβ) are believed to be the culprit for declined brain functions in AD in part through their impairment of neuronal trafficking and synaptic functions. However, the precise cellular actions of Aβ oligo...
Differential arousal regulation by prokineticin 2 signaling in the nocturnal mouse and the diurnal monkey [0.03%]
促动力素2在夜伏昼行的小鼠和昼伏夜行的猴子中的不同调节作用
Qun-Yong Zhou,Katherine J Burton,Matthew L Neal et al.
Qun-Yong Zhou et al.
The temporal organization of activity/rest or sleep/wake rhythms for mammals is regulated by the interaction of light/dark cycle and circadian clocks. The neural and molecular mechanisms that confine the active phase to either day or night ...
Sex-dependent adaptive changes in serotonin-1A autoreceptor function and anxiety in Deaf1-deficient mice [0.03%]
Deaf1缺陷小鼠5-羟色胺自受体功能和焦虑的性别差异适应性变化
Christine Luckhart,Tristan J Philippe,Brice Le François et al.
Christine Luckhart et al.
The C (-1019) G rs6295 promoter polymorphism of the serotonin-1A (5-HT1A) receptor gene is associated with major depression in several but not all studies, suggesting that compensatory mechanisms mediate resilience. The rs6295 risk allele p...