Yuka Hama,Masataka Katsu,Ichigaku Takigawa et al.
Yuka Hama et al.
Genomic variation includes single-nucleotide variants, small insertions or deletions (indels), and copy number variants (CNVs). CNVs affect gene expression by altering the genome structure and transposable elements within a region. CNVs are...
Criteria for identifying the molecular basis of the engram (CaMKII, PKMzeta) [0.03%]
用于识别记忆印痕分子基础的准则(CaMKII，PKMζ)
John Lisman
John Lisman
The engram refers to the molecular changes by which a memory is stored in the brain. Substantial evidence suggests that memory involves learning-dependent changes at synapses, a process termed long-term potentiation (LTP). Thus, understandi...
Lesly Puspita,Sun Young Chung,Jae-Won Shim
Lesly Puspita
Parkinson's disease (PD) is a chronic and progressive neurodegeneration of dopamine neurons in the substantia nigra. The reason for the death of these neurons is unclear; however, studies have demonstrated the potential involvement of mitoc...
Tanshinone I alleviates motor and cognitive impairments via suppressing oxidative stress in the neonatal rats after hypoxic-ischemic brain damage [0.03%]
丹参酮I通过抑制缺血缺氧性脑损伤后新生大鼠的氧化应激来缓解运动和认知障碍
Chunfang Dai,Yannan Liu,Zhifang Dong
Chunfang Dai
Neonatal hypoxia-ischemia is one of the main reasons that cause neuronal damage and neonatal death. Several studies have shown that tanshinone I (TsI), one of the major ingredients of Danshen, exerts potential neuroprotective effect in adul...
Direct interaction with 14-3-3γ promotes surface expression of Best1 channel in astrocyte [0.03%]
直接与14-3-3γ相互作用可促进星形胶质细胞中Best1通道的表面表达
Soo-Jin Oh,Junsung Woo,Young-Sun Lee et al.
Soo-Jin Oh et al.
Background: Bestrophin-1 (Best1) is a calcium-activated anion channel (CAAC) that is expressed broadly in mammalian tissues including the brain. We have previously reported that Best1 is expressed in hippocampal astrocyte...
Mechanistic target of rapamycin is necessary for changes in dendritic spine morphology associated with long-term potentiation [0.03%]
雷帕霉素的机械靶标是与长期增强有关的树突棘形态变化所必需的
Fredrick E Henry,William Hockeimer,Alex Chen et al.
Fredrick E Henry et al.
Alterations in the strength of excitatory synapses in the hippocampus is believed to serve a vital function in the storage and recall of new information in the mammalian brain. These alterations involve the regulation of both functional and...
Light/dark phase-dependent spontaneous activity is maintained in dopamine-deficient mice [0.03%]
多巴胺缺乏型小鼠的昼夜节律依赖性自发活动现象
Masayo Fujita,Yoko Hagino,Taishi Takeda et al.
Masayo Fujita et al.
Dopamine is important for motor control and involved in the regulation of circadian rhythm. We previously found that dopamine-deficient (DD) mice became hyperactive in a novel environment 72 h after the last injection of L-3,4-dihydroxyphen...
Correction to: Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression [0.03%]
关于LRRK2激酶通过p53诱导p21表达的研究的更正通知
Dong Hwan Ho,Hyejung Kim,Jisun Kim et al.
Dong Hwan Ho et al.
Published Erratum
Molecular brain. 2017 Oct 6;10(1):48. DOI:10.1186/s13041-017-0327-6 2017
Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis [0.03%]
缺乏CSGalNAcT1酶的小鼠的行为和神经肽网异常
Nozomu Yoshioka,Shinji Miyata,Atsushi Tamada et al.
Nozomu Yoshioka et al.
Chondroitin sulfate (CS) is an important glycosaminoglycan and is mainly found in the extracellular matrix as CS proteoglycans. In the brain, CS proteoglycans are highly concentrated in perineuronal nets (PNNs), which surround synapses and ...
Novel miR-b2122 regulates several ALS-related RNA-binding proteins [0.03%]
新型miR-b2122调节多个与ALS相关的RNA结合蛋白
Zachary C E Hawley,Danae Campos-Melo,Michael J Strong
Zachary C E Hawley
Common pathological features of amyotrophic lateral sclerosis (ALS) include cytoplasmic aggregation of several RNA-binding proteins. Out of these RNA-binding proteins, TDP-43, FUS/TLS and RGNEF have been shown to co-aggregate with one anoth...