Serotonin enhances neurogenesis biomarkers, hippocampal volumes, and cognitive functions in Alzheimer's disease [0.03%]
血清素通过增加神经发生生物标志物、海马体积和认知功能来对抗阿尔茨海默病
Ali Azargoonjahromi;Alzheimer’s Disease Neuroimaging Initiative
Ali Azargoonjahromi;Alzheimer’s Disease Neuroimaging Initiative
Research on serotonin reveals a lack of consensus regarding its role in brain volume, especially concerning biomarkers linked to neurogenesis and neuroplasticity, such as ciliary neurotrophic factor (CNTF), fibroblast growth factor 4 (FGF-4...
Novelty triggers time-dependent theta oscillatory dynamics in cortical-hippocampal-midbrain circuitry [0.03%]
新颖性引发时间依赖的皮层-海马-中脑回路θ振荡动力学
Alan Jung Park
Alan Jung Park
Rapid adaptation to novel environments is crucial for survival, and this ability is impaired in many neuropsychiatric disorders. Understanding neural adaptation to novelty exposure therefore has therapeutic implications. Here, I found that ...
Dynamic changes in the hippocampal neuronal circuits activity following acute stress revealed by miniature fluorescence microscopy imaging [0.03%]
急性应激下海马神经环路的动态变化——由微型荧光显微影像技术揭示的新现象
Evgenii Gerasimov,Ekaterina Pchitskaya,Olga Vlasova et al.
Evgenii Gerasimov et al.
Coordinated activity of neuronal ensembles is a basis for information processing in the brain. Recent development of miniscope imaging technology enabled recordings of neuronal circuits activity in vivo in freely behaving animals. Acute str...
Knockout of AMPA receptor binding protein Neuron-specific gene 2 (NSG2) enhances associative learning and cognitive flexibility [0.03%]
AMPA受体结合蛋白神经元特异性基因2(NSG2)的敲除可增强联想学习和认知灵活性
Amber J Zimmerman,Antonio Serrano-Rodriguez,Melody Sun et al.
Amber J Zimmerman et al.
The vast majority of gene mutations and/or gene knockouts result in either no observable changes, or significant deficits in molecular, cellular, or organismal function. However, in a small number of cases, mutant animal models display enha...
Post-conditioning sleep deprivation facilitates delay and trace fear memory extinction [0.03%]
睡眠剥夺促进延迟和痕迹恐惧记忆的消退
Daisuke Miyamoto,Mahmoud Abdelmouti Mahmoud
Daisuke Miyamoto
Trace and delay auditory fear conditioning involve different memory association strategies based on working memory involvement; however, their differences in long-term processing through sleep and extinction training remain unclear. While f...
Chemogenetic silencing of the subiculum blocks acute chronic temporal lobe epilepsy [0.03%]
化学遗传学沉默副皮质能阻断急性慢性颞叶癫痫发作
Jianbang Lin,Jing Liu,Qi Zhang et al.
Jianbang Lin et al.
Temporal lobe epilepsy (TLE) is the most common form of medically-intractable epilepsy. Subicular hyperexcitability is frequently observed with TLE, presumably caused by impaired inhibition of local excitatory neurons. Here, we evaluated th...
Synthetic data-driven overlapped neural spikes sorting: decomposing hidden spikes from overlapping spikes [0.03%]
基于合成数据的重叠神经脉冲分类：从重叠脉冲中分解隐藏脉冲
Min-Ki Kim,Sung-Phil Kim,Jeong-Woo Sohn
Min-Ki Kim
Sorting spikes from extracellular recordings, obtained by sensing neuronal activity around an electrode tip, is essential for unravelling the complexities of neural coding and its implications across diverse neuroscientific disciplines. How...
Histamine H3 receptor inverse agonists/antagonists influence intra-regional cortical activity and inter-regional synchronization during resting state: an exploratory cortex-wide imaging study in mice [0.03%]
组胺H3受体非激动性拮抗剂对小鼠静息状态下皮层区域内活动及区域间同步化的影响：全皮层成像的探索性研究
Sentaro Kaita,Yoshikazu Morishita,Kenta Kobayashi et al.
Sentaro Kaita et al.
The histaminergic system plays a key role in modulating learning and memory, wakefulness, and energy balance. Histamine H3 receptors constitutively inhibit the synthesis and release of histamine and other neurotransmitters. Therefore, H3 re...
Transcutaneous auricular vagus nerve stimulation in anesthetized mice induces antidepressant effects by activating dopaminergic neurons in the ventral tegmental area [0.03%]
耳迷走神经经皮刺激通过激活腹侧被盖区多巴胺能神经元产生抗抑郁效应
Tae-Yong Choi,Jeongseop Kim,Ja Wook Koo
Tae-Yong Choi
Depression, a prevalent neuropsychiatric disorder, involves the dysregulation of neurotransmitters such as dopamine (DA). The restoration of DA balance is a pivotal therapeutic target for this condition. Recent studies have indicated that b...
Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism [0.03%]
线粒体酶GPT2缺失引起突触谷氨酸代谢重编
Ozan Baytas,Shawn M Davidson,Julie A Kauer et al.
Ozan Baytas et al.
Recessive loss-of-function mutations in the mitochondrial enzyme Glutamate Pyruvate Transaminase 2 (GPT2) cause intellectual disability in children. Given this cognitive disorder, and because glutamate metabolism is tightly regulated to sus...