Extinction of contextual fear memory is facilitated in TRPM2 knockout mice [0.03%]
TRPM2基因敲除小鼠中上下文恐惧记忆的消退加速
Seung Yeon Ko,Do Gyeong Kim,Huiju Lee et al.
Seung Yeon Ko et al.
Transient receptor potential melastatin type 2 (TRPM2) is a nonselective cation channel involved in synaptic plasticity. We investigated its role in contextual fear conditioning and extinction of conditioned fear using Trpm2-deficient (Trpm...
The properties of TREM1 and its emerging role in pain-related diseases [0.03%]
TREM1的性质及其在痛觉相关疾病中发挥的作用
Zhenzhen Fan,Songtang Sun,Longde Wang et al.
Zhenzhen Fan et al.
The TREM1 receptor, a member of the TREMs family, is expressed by myeloid cells and functions as an initiator or enhancer of the inflammatory response, playing a pivotal role in the regulation of inflammation. In recent years, it has been f...
Roles of mediodorsal thalamus in observational fear-related neural activity in mouse anterior cingulate cortex [0.03%]
内侧背丘脑在小鼠前扣带回皮层观察学习恐惧相关神经元活动中的作用
Kritika Ramesh,Indrajith R Nair,Naoki Yamamoto et al.
Kritika Ramesh et al.
Observational fear (OF) is the ability to vicariously experience and learn from another's fearful situation, enabling adaptive responses crucial for survival. It has been shown that the anterior cingulate cortex (ACC) and basolateral amygda...
Sodium butyrate attenuates microglia-mediated neuroinflammation by modulating the TLR4/MyD88/NF-κB pathway and microbiome-gut-brain axis in cardiac arrest mice [0.03%]
丁酸钠通过调节心搏停止小鼠的TLR4/MyD88/NF-κB通路和微生物群-肠-脑轴来减轻小胶质细胞介导的神经炎症
Jianfei Sun,Liping Lu,Yingtao Lian et al.
Jianfei Sun et al.
Cardiac arrest (CA) is one of the most common illnesses worldwide. Post-CA brain injury (PCABI) is a major cause of death and poor recovery in CA patients and the current CA treatments are not very effective. The microbiome-gut-brain axis h...
Key mechanisms of angiogenesis in the infarct core: association of macrophage infiltration with venogenesis [0.03%]
梗死核心区血管生成的关键机制：巨噬细胞浸润与静脉生成的关联
Luping Xue,Wei Ouyang,Peiyun Qi et al.
Luping Xue et al.
Angiogenesis in the ischemic penumbra compensates for microcirculatory dysfunction and promotes neuronal plasticity after stroke. However, the current understanding may be highly biased because the contribution of veins to angiogenesis has ...
Development of selective deconjugases for membrane-anchored LC3A/B in post-mitotic neurons [0.03%]
用于后有丝分裂神经元膜锚定LC3A/B的选择性去共价酶的开发
Haneul Choi,Sang-Won Park,Deok-Jin Jang et al.
Haneul Choi et al.
Neuronal autophagy is essential for maintaining protein and organelle turnover, thereby safeguarding neuronal health. LC3, a central autophagy protein, exists in lipidated (LC3-II) and non-lipidated (LC3-I) forms, both critical for neurons ...
Changes in the pH value of the human brain in Alzheimer's disease pathology correlated with CD68-positive microglia: a community-based autopsy study in Beijing, China [0.03%]
北京人群脑组织研究发现：CD68阳性小胶质细胞与阿尔茨海默病患者大脑PH值改变相关性分析
Xue Wang,Xiangqi Shao,Liang Yu et al.
Xue Wang et al.
The microenvironment of the central nervous system is highly complex and plays a crucial role in maintaining the function of neurons, which influences Alzheimer's disease (AD) progression. The pH value of the brain is a critical aspect of t...
Transcriptome atlases of rat brain regions and their adaptation to diabetes resolution following gastrectomy in the Goto-Kakizaki rat [0.03%]
胃切除后正常大鼠和GK糖尿病模型大鼠大脑区域的转录组图谱及其对糖尿病缓解的适应性反应
François Brial,Aurélie Le Lay,Claude Rouch et al.
François Brial et al.
Brain regions drive multiple physiological functions through specific gene expression patterns that adapt to environmental influences, drug treatments and disease conditions. To generate a detailed atlas of the brain transcriptome in the co...
Acid sphingomyelinase modulates anxiety-like behavior likely through toll-like receptor signaling pathway [0.03%]
酸性鞘氨醇单胞菌酶通过 Toll 样受体信号通路调控类似焦虑的行为
Huiqi Yuan,Yanan Xu,Hailun Jiang et al.
Huiqi Yuan et al.
Recent studies have shown that abnormal activity of acid sphingomyelinase (Asm) has been associated with a range of psychiatric disorders including schizophrenia and depression. However, the role of Asm in the regulation of anxiety remains ...
Surgery impairs glymphatic activity and cognitive function in aged mice [0.03%]
手术会损害老年小鼠的脑淋巴系统活性及认知功能
Kai Chen,Xingyu Du,Melissa A Chao et al.
Kai Chen et al.
Delirium is a common complication in elderly surgical patients and is associated with an increased risk of dementia. Although advanced age is a major risk factor, the mechanisms underlying postoperative delirium remain poorly understood. Th...