Semaglutide alters behaviour and nucleus accumbens oscillatory activity in healthy mice [0.03%]
司美格鲁肽对健康小鼠的行为和伏隔核振荡活动的影响
Alejo Mosqueira,Sanaz Ansarifar,Sadegh Nabavi et al.
Alejo Mosqueira et al.
Semaglutide, a GLP-1 receptor agonist, is widely studied in metabolic disorders, yet its effects in healthy subjects remain unclear. Here, we show that daily administration of semaglutide (0.1 mg/kg) in healthy mice alters behaviour in vari...
Yamato Hida,Atsushi Shimada,Yeon-Jeong Kim et al.
Yamato Hida et al.
CAST is a core active zone scaffold protein, yet its role in Rab6-dependent trafficking remains unclear. Here, we identify the coiled-coil domain of CAST (CC10) as a direct Rab6-binding module and show that CAST selectively interacts with t...
Temperature-dependent functional inversion of Cav3.2 channels during repetitive activity [0.03%]
温度依赖性的功能反转Cav3.2通道重复活动期间的功能逆轉
Kacper Pawlak,Petr Daněk,Bohumila Jurkovičová-Tarabová et al.
Kacper Pawlak et al.
Temperature strongly influences neuronal excitability and voltage-gated ion channel function. Cav3.2 T-type calcium channels are highly expressed in dorsal root ganglion and trigeminal ganglion neurons, where they contribute to nociceptive ...
Zinc-mediated lysosomal activation by 1H10 enhances autophagy and attenuates tau pathology in Alzheimer's disease models [0.03%]
1H10介导的锌激活溶酶体促进自噬并减轻阿尔茨海默病模型中的Tau病理损害
Jae-Won Eom,Ki-Ryeong Kim,Dong-Hyuk Kim et al.
Jae-Won Eom et al.
Impaired autophagic flux and lysosomal dysfunction contribute critically to the accumulation of pathological protein aggregates in Alzheimer's disease (AD). Emerging evidence suggests that intracellular zinc dynamics regulate lysosomal func...
Comparative analysis of procedural variations in the social defeat stress paradigm in mice: effects of post-defeat housing conditions and aggressor exposure duration [0.03%]
小鼠社交挫败应激范式的程序差异比较分析：赛后饲养条件和攻击者接触时间的影响
Hirotaka Shoji,Tsuyoshi Miyakawa
Hirotaka Shoji
The chronic social defeat stress (CSDS) paradigm is widely used to model psychosocial stress in rodents. Procedural variations across studies may contribute to diverse behavioral outcomes, underscoring the need to clarify the experimental c...
Comparative Study
Molecular brain. 2026 Jul 7;19(1):53. DOI:10.1186/s13041-026-01325-y 2026
Genetically predicted CXCL16 expression is associated with Parkinson's disease risk and peripheral immune cell dysregulation: a two-sample mendelian randomization study [0.03%]
遗传预测的CXCL16表达与帕金森病风险和外周免疫细胞失调相关：两样本孟德尔随机化研究
Zhou Li,Rong Yang,Hao Feng et al.
Zhou Li et al.
Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder with limited disease-modifying therapies. PANoptosis, an integrated form of programmed cell death involving apoptosis, pyroptosis, and necro...
Endovascular stem cell therapy reconfigures post-stroke ER dynamics via GRP78/Atlastin/CHOP axis [0.03%]
血管内干细胞治疗通过GRP78/Atlastin/CHOP轴重塑中风后的内质网动力学
Anita Kumari,Jyoti Yadav,Pratiksha Godse et al.
Anita Kumari et al.
The endoplasmic reticulum (ER) resident chaperon proteins require calcium for post-translational modifications and maintaining ER integrity. Post-stroke dysregulation of ER associated calcium homeostasis leads to altered ER dynamics and neu...
OptoH3R fusion protein mimics β-arrestin-mediated membrane endocytosis of histamine H3 receptor in vitro [0.03%]
体外光学融合蛋白模仿β-逮捕蛋白介导组胺H3受体的胞吞作用
Shuhui Deng,Zhuchen Zhou,Zhong Chen et al.
Shuhui Deng et al.
OptoH3R is an artificial fusion protein that combines the photosensitive elements of rhodopsin with the signaling domain of the histamine H3 receptor (H3R), enabling light-controlled activation of downstream H3R pathways. Although our previ...
Generating models for isoform-specific PKM-KIBRA interactions with BIFC, stabilization and AlphaFold 3 [0.03%]
基于BIFC稳定化和AlphaFold 3生成PKM-KIBRA同种型特异性相互作用模型
Edna Amoah,Tyler W Dunn,Larissa Ferguson et al.
Edna Amoah et al.
The truncated constitutive active form of protein kinase C (PKC) called protein kinase M (PKM) plays a role in long-term memory maintenance in vertebrate and invertebrate models. Previously we have shown that the Aplysia Kidney/Brain protei...
Therapeutic potential of AdipoRon in cognitive, depressive, and anxiety disorders: a systematic review and meta-analysis [0.03%]
阿德普罗酮治疗认知、抑郁和焦虑障碍的潜力：系统评价和荟萃分析
Fatemeh Sadat Gheibi,Leila Hosseini,Parinaz Kalejahi et al.
Fatemeh Sadat Gheibi et al.
Rising cases of cognitive disorders, depression, and anxiety underscore the need for new treatments, given the limited effectiveness and side effects of current options. AdipoRon targets adiponectin receptors and shows promise for protectin...