Tracing cytotoxic effects of small organic Se species in human liver cells back to total cellular Se and Se metabolites [0.03%]
追踪小有机硒物质在人类肝细胞中的细胞毒性效应回到总细胞硒及其代谢物中
T A Marschall,N Kroepfl,K B Jensen et al.
T A Marschall et al.
Small selenium (Se) species play a major role in the metabolism, excretion and dietary supply of the essential trace element selenium. Human cells provide a valuable tool for investigating currently unresolved issues on the cellular mechani...
Na/K-ATPase as a target for anticancer metal based drugs: insights into molecular interactions with selected gold(iii) complexes [0.03%]
金(III)复合物与钠钾 ATP酶的分子相互作用：以抗肿瘤金属基药物为目标
Aleksandra M Bondžić,Goran V Janjić,Miroslav D Dramićanin et al.
Aleksandra M Bondžić et al.
Na/K-ATPase is emerging as an important target for a variety of anticancer metal-based drugs. The interactions of Na/K-ATPase (in its E1 state) with three representative and structurally related cytotoxic gold(iii) complexes, i.e. [Au(bipy)...
Stuart D Portbury,Dominic J Hare,Charlotte J Sgambelloni et al.
Stuart D Portbury et al.
The biological transition metals iron (Fe), copper (Cu) and zinc (Zn) are thought to contribute to the neuronal pathologies that occur following traumatic brain injury (TBI), and indeed our previously published work in young (3 month-old) m...
The effect of metalloprotein inhibitors on cellular metal ion content and distribution [0.03%]
金属蛋白酶抑制剂对细胞内金属离子含量及分布的影响
Yao Chen,Barry Lai,Zhenjie Zhang et al.
Yao Chen et al.
With metalloproteins garnering increased interest as therapeutic targets, designing target-specific metalloprotein inhibitors (MPi) is of substantial importance. However, in many respects, the development and evaluation of MPi lags behind t...
A ubiquitous metal, difficult to track: towards an understanding of the regulation of titanium(iv) in humans [0.03%]
普遍存在的金属 难以追踪：探究钛（IV）在人体中的调节机制
Sergio A Loza-Rosas,Manoj Saxena,Yamixa Delgado et al.
Sergio A Loza-Rosas et al.
Despite the ubiquitous nature of titanium(iv) and several examples of its beneficial behavior in different organisms, the metal remains underappreciated in biology. There is little understanding of how the metal might play an important func...
Application of imaging mass spectrometry approaches to facilitate metal-based anticancer drug research [0.03%]
基于影像质量谱分析方法的抗肿瘤药物研究中的应用探索
Ronald F S Lee,Sarah Theiner,Anders Meibom et al.
Ronald F S Lee et al.
Mass spectrometry imaging is being increasingly used in metal-based anticancer drug development to study elemental and/or molecular drug distributions in different biological systems. The main analytical tools employed are SIMS (especially ...
Copper binding and redox chemistry of the Aβ16 peptide and its variants: insights into determinants of copper-dependent reactivity [0.03%]
铜离子结合及Aβ16肽段及其变异体的氧化还原化学特性研究：关于铜依赖性反应决定特性的新见解
Nineveh Yako,Tessa R Young,Jade M Cottam Jones et al.
Nineveh Yako et al.
The metal-binding sites of Aβ peptides are dictated primarily by the coordination preferences of the metal ion. Consequently, Cu(i) is typically bound with two His ligands in a linear mode while Cu(ii) forms a pseudo-square planar stereoch...
UHPLC-Q-TOF/MS based plasma metabolomics reveals the metabolic perturbations by manganese exposure in rat models [0.03%]
基于UHPLC-Q-TOF/MS的血浆代谢组学揭示了锰暴露大鼠模型中的代谢紊乱现象
Hui Wang,Zhiqi Liu,Shengyi Wang et al.
Hui Wang et al.
Although manganese (Mn) is an essential metal ion biological cofactor, high concentrations could potentially induce an accumulation in the brain and lead to manganism. However, there is no "gold standard" for manganism assessment due to a l...
Substrate specificity and copper loading of the manganese-oxidizing multicopper oxidase Mnx from Bacillus sp. PL-12 [0.03%]
来自PL-12芽孢杆菌的锰氧化多铜氧化酶Mnx的底物特异性和铜载量
Cristina N Butterfield,Bradley M Tebo
Cristina N Butterfield
Manganese(ii) oxidation in the environment is thought to be driven by bacteria because enzymatic catalysis is many orders of magnitude faster than the abiotic processes. The heterologously purified Mn oxidase (Mnx) from marine Bacillus sp. ...
Transcriptome profile of yeast reveals the essential role of PMA2 and uncharacterized gene YBR056W-A (MNC1) in adaptation to toxic manganese concentration [0.03%]
转录体分析发现酿酒酵母适应高锰毒性的两个重要基因PMA2和YBR056W-A(MNC1)
N Andreeva,E Kulakovskaya,A Zvonarev et al.
N Andreeva et al.
Adaptation of S. cerevisiae to toxic concentrations of manganese provides a physiological model of heavy metal homeostasis. Transcriptome analysis of adapted yeast cells reveals upregulation of cell wall and plasma membrane proteins includi...