Organ-specific and time-dependent oxidative damage induced by chronic copper exposure: modulation by vitamin E [0.03%]
慢性接触铜引起的时间及器官特异性氧化损伤：维生素E的调节作用
Christian Saporito Magriñá,Margarita Martinez Sarrasague,Alejandra Cimato et al.
Christian Saporito Magriñá et al.
Chronic exposure to copper ions, Cu(II), induces organ-specific oxidative damage and mitochondrial dysfunction, with distinct temporal and biochemical profiles across tissues. This study evaluated the protective effects of vitamin E (α-toc...
The Cancer Metallome Continuum: A Framework for Understanding Metal Dysregulation from Carcinogenesis to Therapeutic Resistance [0.03%]
癌症金属组连续体：理解从致癌到治疗耐药性的金属失调的框架
Mohamed Ali Hussein,Mahmoud M Mokhtar,Jassy Salim et al.
Mohamed Ali Hussein et al.
Metals and metalloids play essential roles in cancer biology, influencing redox balance, epigenetic regulation, immune responses, and cell death throughout tumour development, progression, and resistance to therapy. Despite this broad biolo...
Smart Cyclometalated Iridium Photosensitizers: Stimuli-Responsive and Theranostic Systems for Precision Phototherapy [0.03%]
智能环金属铱光敏剂：刺激响应及诊疗一体化体系用于精准光动力治疗
Sreejani Ghosh,Priyankar Paira
Sreejani Ghosh
Cyclometalated Iridium(III) complexes have emerged as one of the most versatile classes of photosensitizers for photodynamic therapy (PDT), owing to their tunable photophysics, high phosphorescence quantum yields, and intrinsic capacity for...
Phosphate availability modulates elemental homeostasis in rainbow trout hepatocytes: compositional ionomics illuminates system-wide adjustments [0.03%]
磷酸盐可用性调节虹彩 trout 肝细胞中的元素稳态：组成离子组学揭示系统范围的调整
Punidan D Jeyasingh,Nicholas Hrdlicka,Kristina D Baker et al.
Punidan D Jeyasingh et al.
Phosphorus (P) is central to biology, yet it remains unclear whether P limitation acts as an isolated nutrient constraint or as a perturbation to a dynamical elemental network. We tested this using the rainbow trout liver cell line RTL-W1 b...
Copper restriction unmasks axonal degeneration in a mouse model of X-linked hereditary motor neuropathy [0.03%]
铜限制揭示了X连锁遗传性运动神经病小鼠模型中的轴突变性现象
G Perez-Siles,M Ellis,G J Song et al.
G Perez-Siles et al.
Mutations in the copper (Cu) transporter ATP7A cause a spectrum of X-linked diseases, including Menkes Disease, Occipital horn syndrome and distal hereditary motor neuropathy (dHMNX). We previously generated a conditional knock-in mouse mod...
Genomic Mapping Reveals Cisplatin Disruption of Protein Phosphorylation Signalling Genome-Wide [0.03%]
基因组测绘显示顺铂干扰蛋白质磷酸化信号的全基因组特征
Luyu Qi,Qun Luo,Yinzhu Hou et al.
Luyu Qi et al.
Cisplatin is a DNA-targeting chemotherapeutic. Here we investigate how the cisplatin damaged gene loci are linked to specific protein-driven signalling pathways. An HMGB1a based affinity probe has been constructed and 1,2-cisplatin-crosslin...
The PBAF chromatin remodeling complex contributes to metal homeostasis through MTF1 regulation [0.03%]
PBAF染色质重塑复合物通过调节MTF1参与金属稳态调控
Nick Carulli,Emma E Johnston,David C Klein et al.
Nick Carulli et al.
Chromatin remodeling by SWI/SNF complexes is essential for transcriptional regulation, yet how distinct SWI/SNF subcomplexes contribute to cellular stress responses remains incompletely understood. Here, we identify a specific role for the ...
Advanced methodological framework for speciation analysis of gadolinium in skin tissue following MRI contrast agent exposure [0.03%]
暴露于MRI造影剂后皮肤组织中钆物种分析的先进方法框架
Torben J Maas,Cécile Factor,Izabela Strzeminska et al.
Torben J Maas et al.
A method for quantitative speciation analysis of residual gadolinium in skin following gadolinium-based contrast agent exposure was developed for the first time. Polyethersulfone was identified as a suitable filter material for these compou...
Metallomic profiling of mouse tissues under differential dietary zinc intake [0.03%]
不同锌摄入量条件下小鼠组织的金属组学谱型分析
Suyun Choi,Chaoyi Deng,Yi Wang et al.
Suyun Choi et al.
Zinc is an essential trace element, yet how graded dietary zinc intake reshapes tissue-specific distributions of zinc and other essential metals remains incompletely understood. This study investigated the impact of dietary zinc ranging fro...
Investigating apparent drivers of urinary Ca isotope variability in a sample population [0.03%]
调查采样人群尿液Ca同位素变异性的表观驱动因素
Dan P Razionale,Kate Sanderson,Carlynda Lee et al.
Dan P Razionale et al.
Isotopes of calcium (Ca) in blood and urine have been introduced as a potential clinical tool for monitoring bone mineral balance (BMB). While several works support the ability of Ca isotope composition (δ44/42Ca) to capture a shift in BMB...