Raman Spectroscopic Profiling of Cell Death Induced by Cytotoxic Copper(II), Manganese(II) and Silver(I) complexes containing dicarboxylate and 1,10-Phenanthroline ligands: Novel insights into in vitro mechanisms [0.03%]
含二羧酸和邻菲啶配体的细胞毒性铜（Ⅱ）、锰（Ⅱ）和银（Ⅰ）配合物诱导的细胞死亡的拉曼光谱分析：新的体外作用机制观点
Ella O&#x;Sullivan,Denis O&#x;Shea,Michael Devereux et al.
Ella O&#x;Sullivan et al.
Raman spectroscopy is a label-free, chemically selective technique increasingly employed to probe intracellular biochemical changes associated with drug exposure. Herein, Raman microspectroscopy was applied to evaluate the in vitro response...
Cadmium from smoking increases oxidative stress and metal imbalance in Osteoarthritis [0.03%]
吸烟造成的镉增加氧化应激和金属不平衡以导致骨关节炎发生与发展
Javier Fernández-Torres,Octavio Gamaliel Aztatzi-Aguilar,Gabriela Angélica Martínez-Nava et al.
Javier Fernández-Torres et al.
Knee osteoarthritis (OA) is a leading cause of disability worldwide. Oxidative stress (OS), enhanced by exposure to heavy metals such as cadmium (Cd), may contribute to its progression. Cd, present in tobacco smoke, disrupts chondrocyte via...
Structure and solution biospeciation on tricarbonylrhenium(I) complexes of mercaptopyrimidines with multifaceted biological activity [0.03%]
具有多功能生物活性的嘧啶硫醇配体配合物的结构及其在生物介质中的形态分布研究
Uroš Rapuš,Tamás Pivarcsik,Orsolya Dömötör et al.
Uroš Rapuš et al.
In this study, we report the synthesis and detailed characterization of four novel bidentate (N, N) ligands incorporating a 2-(methylthio)pyrimidine moiety and their fac-tricarbonylrhenium(I) complexes (ReB1-ReB4 and ReB1Aq) with the genera...
Investigation of the reaction of thiomolybdate and copper by electrospray-trapped ion mobility-mass spectrometry (ESI-TIMS-MS) [0.03%]
基于电喷雾囚笼漂移质谱探究含硫钼酸盐与铜的反应
Niklas Bendieck,Arne Behrens,Uwe Karst
Niklas Bendieck
Molecular mass spectrometry was utilised for the first time to gather information of formed compounds consisting of tetrathiomolybdate and Cu in the context of Wilson's disease. Electrospray ionisation-mass spectrometry was used to elucidat...
Diversity in plant δ66Zn values across species and processing protocols: implications for ecological and paleodietary research [0.03%]
植物δ66Zn值的多样性：跨物种和处理方法的差异及其对生态和古饮食研究的意义
Pauline Méjean,Benjamin T Fuller,Laëtitia Leroy et al.
Pauline Méjean et al.
Zinc stable isotope ratios (δ66Zn) are increasingly applied in fields such as archaeology, ecology and medicine, owing to their sensitivity to dietary variations. Despite their growing use, isotopic data for foods, particularly plants, rem...
Imaging Zinc Speciation in the Mouse Hippocampus with µXANES Spectroscopic Mapping [0.03%]
利用µXANES光谱成像映射技术研究小鼠海马区锌离子配位环境
Ashley L Hollings,Meg Willans,Virginie Lam et al.
Ashley L Hollings et al.
Zinc ions (Zn2+) are the second most abundant trace metal ion in the brain of rodents and primates, often serving functions as a structure-stabilizing element or catalytic role. There is an additional pool of Zn2+, ∼15% of total brain Zn2+...
Correlative imaging reveals metal dyshomeostasis and altered zinc coordination environments in a pre-clinical Type 2 diabetes model [0.03%]
相关影像技术揭示了2型糖尿病模型中金属失衡及锌配位环境的改变
Gaewyn Ellison,Arazu Sharif,Meg Willans et al.
Gaewyn Ellison et al.
Zinc ions are highly abundant in pancreatic islet tissue, and multiple lines of evidence link loss of zinc homeostasis to poor glucose regulation in both type 1 and type 2 diabetes. Two major islet zinc-binding proteins, insulin and metallo...
The involvement of calcium related signaling in the detoxification of aluminum in Saccharomyces cerevisiae [0.03%]
钙信号在酵母铝解毒中的作用研究
Rui Yu,Ziye Gan,Ranran Chen et al.
Rui Yu et al.
The molecular mechanism of aluminum toxicity in biological systems remains poorly understood. In this study, the relationship between aluminum and intracellular calcium was investigated in Saccharomyces cerevisiae model cells. Genetic analy...
The Potential Contribution of Metal Dyshomeostasis to the Occurrence of Oral Leukoplakia-through Abnormal Immune Function [0.03%]
金属稳态失衡通过异常免疫功能在口腔黏膜白斑发生中的潜在作用机制研究进展
Luyao Cai,Fei Mao,Xiaoyu Huang et al.
Luyao Cai et al.
Oral leukoplakia is oral potentially malignant disorder with an unclear etiology. Emerging evidence indicates a link between metal dyshomeostasis and carcinogenesis. This study is the first to compare serum concentrations of calcium (Ca), m...
Solution Stability and Storage effect on Selected Metallodrugs: A Multi-Technique Evaluation [0.03%]
溶液稳定性和储存对某些金属药物的影响：多技术评估
Luca Famlonga,Riccardo Di Leo,Lorenzo Chiaverini et al.
Luca Famlonga et al.
Inorganic drugs have a huge impact in medicine, yet their solution behavior in presence of solvents for biological testing is often underestimated, even for clinically established agents. Speciation, hydrolysis, and redox processes can prof...