Inhibiting the BfrB:Bfd interaction in Pseudomonas aeruginosa causes irreversible iron accumulation in bacterioferritin and iron deficiency in the bacterial cytosol [0.03%]
铜绿假单胞菌中抑制BfrB:Bfd相互作用导致细菌铁载体中铁的累积和细胞质中铁的缺乏
Kate Eshelman,Huili Yao,Achala N D Punchi Hewage et al.
Kate Eshelman et al.
Iron is an essential nutrient for bacteria but the reactivity of Fe2+ and the insolubility of Fe3+ present significant challenges to bacterial cells. Iron storage proteins contribute to ameliorating these challenges by oxidizing Fe2+ using ...
In vivo identification of potential uranium protein targets in zebrafish ovaries after chronic waterborne exposure [0.03%]
慢性水生暴露后斑马鱼卵巢中潜在铀蛋白靶点的体内识别
Y Eb-Levadoux,S Frelon,O Simon et al.
Y Eb-Levadoux et al.
Ecotoxicological studies have indicated the reprotoxicity of uranium (U) in zebrafish, but its molecular mechanisms remain unclear. Due to the non-covalent nature of U-protein complexes, canonical proteomics approaches are often not relevan...
Distinctive hippocampal zinc distribution patterns following stress exposure in an animal model of PTSD [0.03%]
慢性应激造模后海马区锌分布的差异模式研究
Hagit Sela,Hagit Cohen,Zeev Karpas et al.
Hagit Sela et al.
Emerging evidence suggests that zinc (Zn) deficiency is associated with depression and anxiety in both human and animal studies. The present study sought to assess whether there is an association between the magnitude of behavioral response...
Whole-brain metallomic analysis of the common marmoset (Callithrix jacchus) [0.03%]
常见狨猴（Callithrix jacchus）全脑金属组分析
B Knauer,P Majka,K J Watkins et al.
B Knauer et al.
Despite the importance of transition metals for normal brain function, relatively little is known about the distribution of these elemental species across the different tissue compartments of the primate brain. In this study, we employed la...
Gaurav Bairwa,Won Hee Jung,James W Kronstad
Gaurav Bairwa
The devastating infections that fungal pathogens cause in humans are underappreciated relative to viral, bacterial and parasitic diseases. In recent years, the contributions to virulence of reductive iron uptake, siderophore-mediated uptake...
Phosphorylation of zinc channel ZIP7 drives MAPK, PI3K and mTOR growth and proliferation signalling [0.03%]
锌通道蛋白ZIP7的磷酸化驱动MAPK、PI3K和mTOR增殖信号通路
T Nimmanon,S Ziliotto,S Morris et al.
T Nimmanon et al.
Zinc is an essential trace element participating in diverse biological processes. Cellular zinc levels are strictly controlled by two families of transport proteins: ZIP channels (SLC39A) and ZnT transporters (SLC30A). ZIP channels increase...
Comparative studies of oxaliplatin-based platinum(iv) complexes in different in vitro and in vivo tumor models [0.03%]
基于奥沙利铂的铂(IV)复合物在不同体外和体内肿瘤模型中的比较研究
Simone Göschl,Ekaterina Schreiber-Brynzak,Verena Pichler et al.
Simone Göschl et al.
Using platinum(iv) prodrugs of clinically established platinum(ii) compounds is a strategy to overcome side effects and acquired resistances. We studied four oxaliplatin-derived platinum(iv) complexes with varying axial ligands in various i...
Comparative Study
Metallomics : integrated biometal science. 2017 Mar 22;9(3):309-322. DOI:10.1039/c6mt00226a 2017
Effect of vanadium on calcium homeostasis, osteopontin mRNA expression, and bone microarchitecture in diabetic rats [0.03%]
钒对糖尿病大鼠钙稳态、骨磷酸蛋白mRNA表达及骨微结构的影响
Cristina Sanchez-Gonzalez,Laura Moreno,Carlos Lopez-Chaves et al.
Cristina Sanchez-Gonzalez et al.
The aim of this study was to examine whether alterations caused by diabetes in calcium homeostasis, expression of osteopontin and the microarchitecture of bone are corrected by exposure to vanadium. Four study groups were examined over a pe...
Unravelling the role of protein kinase CK2 in metal toxicity using gene deletion mutants [0.03%]
利用基因敲除突变体解析蛋白激酶CK2在金属毒性的作用
Adam J Johnson,Mohammad S Zaman,Filip Veljanoski et al.
Adam J Johnson et al.
Metal ions, biologically essential or toxic, are present in the surrounding environment of living organisms. Understanding their uptake, homeostasis or detoxification is critical in cell biology and human health. In this study, we investiga...