Arsenolipids exert less toxicity in a human neuron astrocyte co-culture as compared to the respective monocultures [0.03%]
与单培养相比，砷脂质在人神经元星形胶质细胞共培养中的毒性较低
B Witt,J Bornhorst,H Mitze et al.
B Witt et al.
Arsenic-containing hydrocarbons (AsHCs), natural products found in seafood, have recently been shown to exert toxic effects in human neurons. In this study we assessed the toxicity of three AsHCs in cultured human astrocytes. Due to the hig...
Cisplatin resistance in cell models: evaluation of metallomic and biological predictive biomarkers to address early therapy failure [0.03%]
细胞模型中的顺铂耐药性评估金属组和生物预测生物标志物以解决早期治疗失败问题
Marta Espina,Mario Corte-Rodríguez,Leticia Aguado et al.
Marta Espina et al.
Cisplatin, one of the most extensively used metallodrugs in cancer treatment, presents the important drawback of patient resistance. This resistance is the consequence of different processes including those preventing the formation of DNA a...
Flexible aspartates propel iron to the ferroxidation sites along pathways stabilized by a conserved arginine in Dps proteins from Mycobacterium smegmatis [0.03%]
结核分支杆菌Dps蛋白中柔性的天冬氨酸使铁在由保守的精氨酸稳定的作用途径上向铁氧化位点移动
Sunanda Margrett Williams,Dipankar Chatterji
Sunanda Margrett Williams
DNA-binding proteins under starvation (Dps) are dodecameric nano-compartments for iron oxidation and storage in bacterial cells. These proteins have roughly spherical structures with a hollow interior where iron is stored. Through mutationa...
Iron isotopic composition of blood serum in anemia of chronic kidney disease [0.03%]
慢性肾脏疾病贫血患者血液中铁同位素组成
Yulia Anoshkina,Marta Costas-Rodríguez,Marijn Speeckaert et al.
Yulia Anoshkina et al.
Chronic kidney disease (CKD) is a general term for disorders that affect the structure and function of the kidneys. Iron deficiency (ID) and anemia occur in the vast majority of CKD patients, most of whom are elderly. However, establishing ...
Imaging metals in biology: pictures of metals in health and disease [0.03%]
生物金属 imaging：健康与疾病中的金属图片
Dominic J Hare,Elizabeth J New,Gawain McColl
Dominic J Hare
Tight binding of heme to Staphylococcus aureus IsdG and IsdI precludes design of a competitive inhibitor [0.03%]
链球菌IsdG和IsdI与原卟啉 IX 紧密结合使其很难设计出竞争性的抑制剂
Matthew A Conger,Deepika Pokhrel,Matthew D Liptak
Matthew A Conger
The micromolar equilibrium constants for heme dissociation from IsdG and IsdI reported in the literature call into question whether these enzymes are actually members of the iron-regulated surface determinant system of Staphylococcus aureus...
Platinum transfer from hCTR1 to Atox1 is dependent on the type of platinum complex [0.03%]
铂转移由hCTR1到Atox1取决于铂复合物的类型
Xuelei Wu,Siming Yuan,Erqiong Wang et al.
Xuelei Wu et al.
In spite of their wide application, the cellular uptake of platinum based anticancer drugs is still unclear. The copper transport protein, hCTR1, is proposed to facilitate the cellular uptake of cisplatin, whereas organic cation transport (...
Selenadiazole derivatives antagonize hyperglycemia-induced drug resistance in breast cancer cells by activation of AMPK pathways [0.03%]
糖醇诱导的乳腺癌药耐受性的硒氮杂环衍生物拮抗作用及活化AMPK通路的作用机制研究
Jianfu Zhao,Delong Zeng,Yuedan Liu et al.
Jianfu Zhao et al.
Hyperglycemia is an important factor for chemoresistance of breast cancer patients with diabetes. In the present study, a novel selenadiazole derivative has been evaluated and found to be able to antagonize the doxorubicin (DOX) resistance ...
High-affinity metal binding by the Escherichia coli [NiFe]-hydrogenase accessory protein HypB is selectively modulated by SlyD [0.03%]
SlyD选择性调节埃希氏大肠杆菌[NiFe]氢酶辅助蛋白HypB的高亲和力金属结合能力
Mozhgan Khorasani-Motlagh,Michael J Lacasse,Deborah B Zamble
Mozhgan Khorasani-Motlagh
[NiFe]-hydrogenase, which catalyzes the reversible conversion between hydrogen gas and protons, is a vital component of the metabolism of many pathogens. Maturation of [NiFe]-hydrogenase requires selective nickel insertion that is completed...
Biology and toxicology of tellurium explored by speciation analysis [0.03%]
speciation分析探索的碲的生物学和毒理学
Yasumitsu Ogra
Yasumitsu Ogra
Tellurium (Te) is widely used in industry because it has unique physicochemical properties. Although Te is a non-essential element in animals and plants, it is expected to be metabolized to organometallic compounds having a carbon-Te bond i...