Siming Yuan,Siming Chen,Zhaoyong Xi et al.
Siming Yuan et al.
The cellular copper level is strictly regulated since excessive copper is harmful to cells. It has been proposed that the expression of copper transport protein hCtr1 is transcriptionally regulated by specificity protein 1 (Sp1) in response...
Hiroki Haraguchi
Hiroki Haraguchi
In 2004, the term "metallomics" was coined to describe integrated biometal science (H. Haraguchi, Metallomics as Integrated Biometal Science, J. Anal. At. Spectrom., 2004, 19, 5-14). Around 10 years have passed since then, and the history o...
Characterization of a highly efficient antibiotic-degrading metallo-β-lactamase obtained from an uncultured member of a permafrost community [0.03%]
从永久冻土微生物群中的一种未培养成员中获得的高效抗生素降解金属-β-内酰胺酶的特征分析
Marcelo Monteiro Pedroso,Christopher Selleck,Charmaine Enculescu et al.
Marcelo Monteiro Pedroso et al.
Antibiotic resistance is a major global health problem, one that threatens to derail the benefits garnered from arguably the greatest success of modern medicine, the discovery of antibiotics. Among the most potent agents contributing to ant...
Elemental bio-imaging of PEGylated NaYF4:Yb/Tm/Gd upconversion nanoparticles in mice by laser ablation inductively coupled plasma mass spectrometry to study toxic side effects on the spleen, liver and kidneys [0.03%]
用于研究PEG修饰的NaYF4:Yb/Tm/Gd上转换纳米颗粒在小鼠脾脏、肝脏和肾脏毒副作用的激光剥蚀电感耦合等离子体质谱元素生物成像
Qing Li,Zheng Wang,Yirui Chen et al.
Qing Li et al.
Rare-earth upconversion nanoparticles (UCNPs) are considered stable nanoprobes with low toxicity and deep tissue penetration. However, the increasing use of UCNPs has raised concerns about their potential toxicity in living organisms. Very ...
Justin C Cikomola,María R Flórez,Marta Costas-Rodríguez et al.
Justin C Cikomola et al.
The Fe isotopic composition of an individual's whole blood has recently been shown to be an interesting clinical indicator of Fe status. The present study aimed to evaluate the influence of several endemic characteristics of a representativ...
Ferrocene-cinchona hybrids with triazolyl-chalcone linkers act as pro-oxidants and sensitize human cancer cell lines to paclitaxel [0.03%]
含三唑查尔格伦桥连基的费尔斯酮杂合物可充当助氧化剂并增加人癌细胞系对紫杉醇的敏感性
Ana Podolski-Renić,Szilvia Bősze,Jelena Dinić et al.
Ana Podolski-Renić et al.
Recently, we demonstrated that ferrocene-containing compounds with a cinchona moiety displayed marked anticancer activity. Here we report on the effects of the most promising isomers encompassing quinine- (compounds 4 and 5) and quinidine-e...
Schizosaccharomyces pombe Grx4 regulates the transcriptional repressor Php4 via [2Fe-2S] cluster binding [0.03%]
裂殖酵母Grx4通过与[2Fe-2S]伴侣蛋白结合调控转录抑制因子Php4
Adrienne C Dlouhy,Jude Beaudoin,Simon Labbé et al.
Adrienne C Dlouhy et al.
The fission yeast Schizosaccharomyces pombe expresses the CCAAT-binding factor Php4 in response to iron deprivation. Php4 forms a transcription complex with Php2, Php3, and Php5 to repress the expression of iron proteins as a means to econo...
Activation of Nrf2/ARE signaling pathway attenuates lanthanum chloride induced injuries in primary rat astrocytes [0.03%]
Nrf2/ARE信号通路活化减轻氯化镧诱导的原代大鼠星形胶质细胞损伤
Lijin Zhang,Jinghua Yang,Shengwen Wu et al.
Lijin Zhang et al.
Lanthanum (La) exposure can lead to learning and memory disorder in animals; however, the underlying mechanism of La induced neurotoxicity is still unknown. It has been demonstrated that Nrf2 activation by tert-butylhydroquinone (tBHQ) resu...
Recent structural insights into the function of copper nitrite reductases [0.03%]
近来有关铜硝酸盐还原酶功能的结构见解
Sam Horrell,Demet Kekilli,Richard W Strange et al.
Sam Horrell et al.
Copper nitrite reductases (CuNiR) carry out the first committed step of the denitrification pathway of the global nitrogen cycle, the reduction of nitrite (NO2-) to nitric oxide (NO). As such, they are of major agronomic and environmental i...
Remarkable differences in the biochemical fate of Cd2+, Hg2+, CH3Hg+ and thimerosal in red blood cell lysate [0.03%]
红细胞裂解物中Cd2+、Hg2+、甲基汞和硫代汞盐的生化命运差异显著
Matthew A Gibson,Sophia Sarpong-Kumankomah,Susan Nehzati et al.
Matthew A Gibson et al.
Humans are environmentally exposed to potentially toxic Cd and Hg species and to the Hg compound thimerosal (THI), an antibactericidal vaccine additive. Previous studies have revealed that Cd2+, Hg2+ and CH3Hg+ are taken up by red blood cel...