Heavy Medicine: The Need for Ethical Stewardship of Metal and Metalloid-based Medicines and Technologies [0.03%]
沉重的医药：金属和类金属基医药和技术创新伦理管理的需求
Patrick Day
Patrick Day
Metals and metalloids including cobalt, gadolinium, lutetium and germanium are used in numerous medical applications spanning diverse specialities including orthopedics, radiology, oncology and healthcare artificial intelligence. These medi...
Seth Nobert,Haley Wolgien-Lowe,Tamara Davis et al.
Seth Nobert et al.
Non-enzymatic glycation is the chemical reaction between the amine group of an amino acid and the carbonyl group of a reducing sugar. The final products of this reaction, advanced glycation end-products (AGEs), are known to play a key role ...
Metals in the gut: microbial strategies to overcome nutritional immunity in the intestinal tract [0.03%]
肠道内的金属元素：微生物克服肠腔营养免疫的策略
Marisa S Egan,Raquel de Macedo,Joseph P Zackular
Marisa S Egan
Trace metals are indispensable nutritional factors for all living organisms. During host-pathogen interactions, they serve as crucial resources that dictate infection outcomes. Accordingly, the host uses a defense strategy known as nutritio...
Linking the transcriptome to physiology: response of the proteome of Cupriavidus metallidurans to changing metal availability [0.03%]
转录组与生理的联系：Cupriavidus metallidurans对金属可得性变化的蛋白反应
Diana Galea,Martin Herzberg,Dirk Dobritzsch et al.
Diana Galea et al.
Cupriavidus metallidurans CH34 is a metal-resistant bacterium. Its metal homeostasis is based on a flow equilibrium of metal ion uptake and efflux reactions, which adapts to changing metal concentrations within an hour. At high metal concen...
Jinke Liu,Guilin Han,Yu Tian et al.
Jinke Liu et al.
Kidney stones, as typical biominerals produced within the human body, pose a significant threat to human health, affecting over 12% of the global population. However, the exact mechanisms underlying their formation are not fully understood....
Antisense transcription is associated with expression of metal resistance determinants in Cupriavidus metallidurans CH34 [0.03%]
铜抗性菌株Cupriavidus metallidurans CH34中铁调控反义转录与金属抗性决定因子表达之间的关系研究
Cornelia Große,Jan Grau,Martin Herzberg et al.
Cornelia Große et al.
Cupriavidus metallidurans is able to thrive in metal-rich environments but also survives metal starvation. Expression of metal resistance determinants in C. metallidurans was investigated on a global scale. Cupriavidus metallidurans was cha...
Formation mechanism of iron-catechol complexes in the colored periostracum of Corbicula spp [0.03%]
环萝卜螺属双壳类彩色介壳中铁-儿茶酚复合物的形成机制研究
Kuniko Takemoto,Masataka Murakami,Yoshihiro Ueno et al.
Kuniko Takemoto et al.
The shell color of Corbicula clams, which are globally distributed, is roughly divided into yellowish and blackish depending on the environmental conditions of the sediment. The formation of an iron-L-3,4-dihydroxyphenylalanine (DOPA) compl...
X-ray fluorescence mapping of brain tissue reveals the profound extent of trace element dysregulation in stroke pathophysiology [0.03%]
基于脑组织的X射线荧光定位图谱揭示了中风病理生理过程中微量元素失调的程度
M Jake Pushie,Nicole J Sylvain,Huishu Hou et al.
M Jake Pushie et al.
The brain is a privileged organ with regard to its trace element composition and maintains a robust barrier system to sequester this specialized environment from the rest of the body and the vascular system. Stroke is caused by loss of adeq...
Alterations in zinc, copper, and iron levels in the retina and brain of Alzheimer's disease patients and the APP/PS1 mouse model [0.03%]
阿尔茨海默病患者及APP / PS1小鼠模型视网膜和大脑中锌、铜和铁水平的变化
Seyed Mostafa Hosseinpour Mashkani,David P Bishop,Mika T Westerhausen et al.
Seyed Mostafa Hosseinpour Mashkani et al.
Transition metals like copper (Cu), iron (Fe), and zinc (Zn) are vital for normal central nervous system function and are also linked to neurodegeneration, particularly in the onset and progression of Alzheimer's disease (AD). Their alterat...
Cellular targets of cytotoxic copper phenanthroline complexes: a multimodal imaging quantitative approach in single PC3 cells [0.03%]
单个PC3细胞中铜菲咯啉复合物细胞毒性靶点的多模态成像定量方法研究
Teresa Pinheiro,Luís C Alves,António P Matos et al.
Teresa Pinheiro et al.
Metal complexes are emerging as promising alternatives to traditional platinum-based cancer treatments, offering reduced side effects. However, understanding their cellular uptake and distribution and quantifying their presence at the singl...