Rust and Redemption: Iron-Sulfur Clusters and Oxygen in Human Disease and Health [0.03%]
铁硫簇和氧在人类疾病与健康中的作用及复苏之路
Shany Egozi,Tslil Ast
Shany Egozi
Iron-sulfur (Fe-S) clusters are ancient and versatile cofactors that drive essential cellular functions, from electron transport to enzyme catalysis. Their intrinsic sensitivity to oxidation has shaped the evolution of specialized Fe-S clus...
Proteomic profiling of zinc homeostasis mechanisms in Pseudomonas aeruginosa through data-dependent and data-independent acquisition mass spectrometry [0.03%]
基于数据依赖和数据非依赖型获取质谱技术的铜绿假单胞菌锌稳态机制蛋白质谱分析
Annaliese C S Meyer,Matthew R McIlvin,Paloma Zaria Lopez et al.
Annaliese C S Meyer et al.
Zinc is central to the function of many proteins, yet the mechanisms of zinc homeostasis and their interplay with other cellular systems remain underexplored. In this study, we employ data-dependent acquisition (DDA) and data-independent ac...
Association of Metal Elements deposition with Symptomatic Carotid Artery Stenosis and Their Spatial Distribution in atherosclerosis plaques [0.03%]
金属元素沉积与症状性颈动脉狭窄及在动脉粥样硬化斑块中空间分布的相关性研究
Liangran Huang,Yacong Liu,Lebao Yu et al.
Liangran Huang et al.
Purpose: Metals in circulation and urine had been implicated in atherosclerosis progression, but spatial distribution of metals within plaques and their association with plaque stability remained unclear. This study aimed...
Zinc-mediated dynamics of CD4/CD8α co-receptors and Lck kinase: Implications for zinc homeostasis, immune response, and biotechnological innovations [0.03%]
锌介导的CD4/CD8α共受体和Lck激酶的动力学：对锌稳态、免疫反应和技术创新的影响
Anna Kocyła,Artur Krężel
Anna Kocyła
Zinc (Zn²⁺) plays a pivotal role in T-cell activation by modulating the interactions between the co-receptors CD4 and CD8α and the Src-family kinase Lck. A central structural feature in this regulation is the zinc clasp, a Zn²⁺-mediate...
Selenoneine scavenges hydroxyl radicals by self-oxidation in hydrogen peroxide and by forming seleninic acid, which is reduced back to selenoneine [0.03%]
硒翁因通过自身氧化清除过氧化氢中的羟自由基并形成硒nic酸，后者被还原回硒翁因
Takuya Seko,Hajime Uchida,Shintaro Imamura et al.
Takuya Seko et al.
Selenoneine (SEN), a selenium analog of ergothioneine (EGT), is widely distributed in marine fishes and is a strong radical scavenger. Electron spin resonance (ESR) spectrometry showed that SEN monomer and dimer directly scavenged ·OH gene...
Dynamic intra-renal changes in cadmium distribution detected by LA-ICP-MS in mice administered cadmium-metallothionein [0.03%]
激光消融电感耦合等离子体质谱技术用于研究给予镉-金属硫蛋白的小鼠肾内分布动态变化
Hitomi Fujishiro,Kanako Matsumoto,Hitomi Umemoto et al.
Hitomi Fujishiro et al.
Administration of cadmium-metallothionein (Cd-MT) complex has been known to cause acute nephrotoxicity due to free Cd ions during the breakdown of the Cd-MT protein in renal cells. However, the fate of the renal Cd after Cd-MT administratio...
Biosynthesis and Assembly of Hydrogenase [NiFe]-Cofactor: Recent Advances and Perspectives [0.03%]
氢酶[NiFe]辅因子的生物合成与装配：近期进展与展望
R Gary Sawers,Maximilian Hardelt,Alexander Haase et al.
R Gary Sawers et al.
The large subunit of all [NiFe]-hydrogenases in bacteria and archaea has a heterobimetallic NiFe(CN)2CO cofactor coordinated by four cysteine residues. The iron ion has two cyanides and a carbon monoxide as diatomic ligands. Six ancillary H...
A Conserved Aspartate Residue in [4Fe-4S]-Containing HypD is Required for [NiFe]-Cofactor Biosynthesis and for Efficient Interaction of the HypCD Scaffold Complex with HypE [0.03%]
含[4Fe-4S]的HypD中保守的天冬氨酸残基要求用于[nife]辅因子生物合成及对于HypCD支架复合物与HypE有效作用的要求
Alexander Haase,Christian Arlt,Maximilian Hardelt et al.
Alexander Haase et al.
Six Hyp (A through F) proteins synthesise the NiFe(CN)2CO cofactor found in all [NiFe]-hydrogenases. The Fe(CN)2CO moiety of this cofactor is assembled on a separate scaffold complex comprising HypC and HypD. HypE and HypF generate the cyan...
The Metal(loid)s' Dilemma. What's the next step for a new era of inorganic molecules in medicine? [0.03%]
金属(类金属)的困境。医学中无机分子新时代的下一步是什么？
Lorenzo Chiaverini,Riccardo Di Leo,Luca Famlonga et al.
Lorenzo Chiaverini et al.
In this paper, we critically examine the key challenges associated with the development of inorganic drugs, a field that remains underrepresented despite its significant therapeutic potential. Currently, most clinically approved pharmaceuti...
Synthesis, characterization, DNA interaction studies, and biological evaluation of copper(II) hybrids containing azole drugs and intercalating ligands against neglected diseases [0.03%]
含唑类药物和嵌入配体的铜（II）杂化物的合成、表征、DNA相互作用研究及生物评价用于治疗被忽视疾病
José Aleixo de Azevedo-França,Victor Feliciano Dos Santos Ramos,Patrícia Salvador Tessaro et al.
José Aleixo de Azevedo-França et al.
In an attempt to treat neglected diseases such as leishmaniasis and fungal infections, three novel copper(II) hybrid have been developed: [Cu(dppz)(CTZ)(NO3)](NO3) (1), [Cu(dppz)(KTZ)(H2O)(NO3)](NO3) (2), [Cu(dppz)(FLZ)(NO3)]2(NO3)2 (3). Th...