Evidence for decreased copper associated with demyelination in the corpus callosum of cuprizone-treated mice [0.03%]
杯挫铜处理的小鼠胼胝体脱髓鞘与铜含量下降的证据
James B W Hilton,Kai Kysenius,Jeffrey R Liddell et al.
James B W Hilton et al.
Demyelination within the central nervous system (CNS) is a significant feature of debilitating neurological diseases such as multiple sclerosis and administering the copper-selective chelatorcuprizone to mice is widely used to model demyeli...
TauSTED super-resolution imaging of labile iron in primary hippocampal neurons [0.03%]
TauSTED超高分辨率成像初级海马神经元中不稳定的铁离子
Aiyarin Kittilukkana,Asuncion Carmona,Chalermchai Pilapong et al.
Aiyarin Kittilukkana et al.
Iron dyshomeostasis is involved in many neurological disorders, particularly neurodegenerative diseases where iron accumulates in various brain regions. Identifying mechanisms of iron transport in the brain is crucial for understanding the ...
Nicolas Fierling,Patrick Billard,Pascale Bauda et al.
Nicolas Fierling et al.
The increasing use of lithium (Li) in new technologies raises the question of its impact on living microorganisms. In the present study, we aimed to identify putative Li targets and resistance mechanisms in the yeast model Saccharomyces cer...
Histatin-5 interacts with cellular copper to promote antifungal activity against Candida albicans [0.03%]
组蛋白衍生的宿主抗菌肽与细胞铜协同促进对白色念珠菌的抗真菌作用
Joanna X Campbell,Natalie B Schulte,Barry Lai et al.
Joanna X Campbell et al.
Histatin-5 (Hist-5) is an antimicrobial peptide found in human saliva that functions to defend the oral cavity from microbial infections, such as those caused by the fungal pathogen Candida albicans (C. albicans). Hist-5 can bind Cu in mult...
The transporter PHO84/NtPT1 is a target of aluminum to affect phosphorus absorption in Saccharomyces cerevisiae and Nicotiana tabacum L [0.03%]
铝通过影响酿酒酵母和烟草原生质体磷的吸收以PHO84/NtPT1为作用靶点
Zhiwei Huang,Shixuan Zhang,Ranran Chen et al.
Zhiwei Huang et al.
The molecular mechanism of aluminum toxicity in biological systems is not completely understood. Saccharomyces cerevisiae is one of the most used model organisms in the study of environmental metal toxicity. Using an unbiased metallomic app...
Characterization of genes involved in micronutrients and toxic metals detoxification in Brassica napus by genome-wide cDNA library screening [0.03%]
油菜基因组cDNA芯片的构建及微量营养元素和有毒金属解毒相关基因的研究
Jia-Shi Peng,Xue-Jie Zhang,Jia-Ni Xiong et al.
Jia-Shi Peng et al.
Stresses caused by deficiency/excess of mineral nutrients or of pollution of toxic metals have already become a primary factor in limiting crop production worldwide. Genes involved in minerals and toxic metals accumulation/tolerance could b...
Selenomethionine supplementation and expression of selenosugars, selenocysteine, and other selenometabolites in rat liver [0.03%]
硒代蛋氨酸补充与大鼠肝脏中硒糖、硒代半胱氨酸及其他硒代谢产物的生成关系研究
Katarzyna Bierla,Joanna Szpunar,Ryszard Lobinski et al.
Katarzyna Bierla et al.
Selenomethionine (SeMet) as a methionine analog can be incorporated into protein. In turkeys, we recently found that selenium (Se) as selenite is not metabolized to SeMet but rather to selenosugars (seleno-N-acetyl galactosamine) bound to p...
Effect of graded levels of selenium supplementation as selenite on expression of selenosugars, selenocysteine, and other selenometabolites in rat liver [0.03%]
不同剂量硒(亚硫酸盐)补充对大鼠肝脏硒糖、硒代半胱氨酸及其他硒代谢产物表达的影响
Katarzyna Bierla,Joanna Szpunar,Ryszard Lobinski et al.
Katarzyna Bierla et al.
Using high pressure liquid chromatography (HPLC) coupled with selenium-specific inductively coupled plasma mass spectrometry (ICP-MS) and molecule specific (Orbitrap MS/MS) detection, we previously found that far more selenium (Se) is prese...
Diet, cellular, and systemic homeostasis control the cycling of potassium stable isotopes in endothermic vertebrates [0.03%]
饮食、细胞和系统稳态控制恒温脊椎动物钾稳定同位素的循环
T Tacail,J Lewis,M Clauss et al.
T Tacail et al.
The naturally occurring stable isotopes of potassium (41K/39K, expressed as δ41K) have the potential to make significant contributions to vertebrate and human biology. The utility of K stable isotopes is, however, conditioned by the unders...