Adulticide treatment with melarsomine: outcome in 283 heartworm-positive dogs in Germany [0.03%]
德国犬心丝虫病硫砷片治疗283例临床转归研究
Imke Maerz,Sophie Rütjes,Sebastian Genz et al.
Imke Maerz et al.
Background: Heartworm disease is of increasing significance in Europe because of climate change and the movement of dogs from endemic regions. Despite guidelines from the American Heartworm Society (AHS) and the European ...
A Vismarra,M Fozzer,J W McCall et al.
A Vismarra et al.
Wolbachia is the most widespread endosymbiont in animals, and its discovery in Dirofilaria immitis significantly advanced our understanding of heartworm disease (HWD). In 1995, Sironi and colleagues from the universities of Milan and Pavia,...
Endothelial proteomic response to Dirofilaria repens somatic antigens and the Dr20/22 protein reveals parasite-driven modulation of angiogenesis [0.03%]
恶丝虫体液抗原和Dr20 / 22蛋白的内皮蛋白质组学反应揭示了寄生虫驱动的血管生成调控作用
Manuel Collado-Cuadrado,Ana Montero-Calle,Sara Vázquez-Ávila et al.
Manuel Collado-Cuadrado et al.
Background: Although Dirofilaria repens induces perivascular proliferation in subcutaneous nodules, the molecular factors driving this angiogenic response remain unknown. The objective of this study is to investigate the ...
Potential risk of heartworm infection in the United States of America and its projected incidence by 2100 [0.03%]
美国端局感染的风险及其到2100年的发病数预测
Rodrigo Morchón,Iván Rodríguez-Escolar,Manuel Collado-Cuadrado et al.
Rodrigo Morchón et al.
Background: Heartworm disease, caused by the parasitic roundworm Dirofilaria immitis, is a vector-borne zoonosis transmitted by culicid mosquitoes and widely distributed in the USA, where prevalence is highest in the sout...
Blocking Dirofilaria immitis transmission by treatment of heartworm microfilaremic dogs with doxycycline [0.03%]
多西环素治疗犬恶丝虫微丝蚴血症以阻断恶丝虫传播
John Wilson McCall,Abdelmoneim Mansour,Utami DiCosty et al.
John Wilson McCall et al.
Background: This study was conducted to determine whether heartworm infective larvae (L3) from mosquitoes fed earlier on blood from dogs during daily administration of doxycycline at various dosages and treatment schedule...
Improved specificity of a probe-based real-time PCR for the detection of Dirofilaria immitis in canine blood [0.03%]
一种检测犬血液中狄氏巴贝虫的探针型实时定量PCR方法的改进
Maureen A Kelly,Tiana L Sanders,Alexa Starnes et al.
Maureen A Kelly et al.
Background: Dirofilaria immitis is a vector-borne filarioid nematode distributed worldwide and endemic across most of North America. In dogs, it is considered the most clinically significant parasite and a known cause of ...
A retrospective comparison of two-dose and three-dose melarsomine, with doxycycline and a macrocyclic lactone, in 1246 shelter dogs [0.03%]
回顾性比较两剂和三剂米尔阿索明联合多西环素和大环内酯类药物治疗1246只流浪狗的效果
Linda S Jacobson,Brian A DiGangi,Maria A Serrano et al.
Linda S Jacobson et al.
Background: Doxycycline and a macrocyclic lactone (ML/doxy) are now standard additions to melarsomine treatment protocols. The safety and efficacy of the two-dose melarsomine protocol have not been revisited since these a...
Comparative Study
Parasites & vectors. 2026 Aug 20;19(1):359. DOI:10.1186/s13071-026-07344-x 2026
Assessing the performance of trūRapid™ FOUR heartworm antigen test for early detection in experimentally infected dogs in comparison to other point-of-care tests [0.03%]
评估trūRapid™ FOUR心脏丝虫抗原试验在实验感染犬中的早期检测效果与其他现场即时检测方法的比较
Pabasara Weerarathne,Tiana L Sanders,Alexa Starnes et al.
Pabasara Weerarathne et al.
Background: The American Heartworm Society (AHS) recommends diagnosing canine heartworm (HW) infection using both antigen and microfilaria detection tests. Antigen-antibody immune complexes may block antigen detection. Th...
Comparative Study
Parasites & vectors. 2026 Aug 20;19(1):353. DOI:10.1186/s13071-026-07450-w 2026
Comparison of two doxycycline dosages on inflammatory and stress response in dogs naturally infected with Dirofilaria immitis [0.03%]
不同多西环素剂量对自然感染犬恶丝虫犬的炎性及应激反应的影响比较
Daniel Julio Vera-Rodríguez,Rodrigo Morchón,Beatriz Regina Morales et al.
Daniel Julio Vera-Rodríguez et al.
Background: Canine heartworm disease, caused by Dirofilaria immitis, is characterized by a marked inflammatory response largely driven by its endosymbiotic bacterium Wolbachia pipientis. Doxycycline is routinely incorpora...
Comparative Study
Parasites & vectors. 2026 Aug 20;19(1):357. DOI:10.1186/s13071-026-07505-y 2026
Comparative proteomic analysis of the angiogenic response in an in vitro model of vascular endothelial cells to excretory/secretory and somatic antigens of Dirofilaria immitis [0.03%]
爱迪生氏丝虫排泄分泌和体液组分诱导的血管内皮细胞应答的蛋白质组学分析
Manuel Collado-Cuadrado,Alfonso Balmori-de la Puente,Ana Montero-Calle et al.
Manuel Collado-Cuadrado et al.
Background: Dirofilaria immitis infection induces endothelial inflammation and vascular remodeling, contributing to heartworm disease pathology. While excretory/secretory antigens (DiES) are known to promote angiogenesis,...
Comparative Study
Parasites & vectors. 2026 Aug 20;19(1):351. DOI:10.1186/s13071-026-07307-2 2026