Cyclophosphamide in multiple sclerosis: scientific rationale, history and novel treatment paradigms [0.03%]
环磷酰胺治疗多发性硬化症：科学依据、历史及新型治疗策略
Amer Awad,Olaf Stüve
Amer Awad
For patients with relapsing-remitting multiple sclerosis (RRMS), there are currently six approved medications that have been shown to alter the natural course of the disease. The approved medications include three beta interferon formulatio...
Benefit of repetitive intrathecal triamcinolone acetonide therapy in predominantly spinal multiple sclerosis: prediction by upper spinal cord atrophy [0.03%]
反复鞘内注射三氯醋酸倍他米松治疗以脊髓为主的多发性硬化症的益处：由颈椎萎缩预测
Carsten Lukas,Barbara Bellenberg,Horst K Hahn et al.
Carsten Lukas et al.
Intrathecal injection of triamcinolone acetonide (TCA) has been shown to provide substantial benefit in a subset of progressive multiple sclerosis (MS) patients with predominant spinal symptoms. We examined whether atrophy of the upper spin...
Stuart H Isaacson,Robert A Hauser
Stuart H Isaacson
Motor symptoms in Parkinson's disease (PD) are caused by a severe loss of pigmented dopamine-producing nigro-striatal neurons. Symptomatic therapies provide benefit for motor features by restoring dopamine receptor stimulation. Studies have...
S J Groiss,L Wojtecki,M Südmeyer et al.
S J Groiss et al.
During the last 15 years deep brain stimulation (DBS) has been established as a highly-effective therapy for advanced Parkinson's disease (PD). Patient selection, stereotactic implantation, postoperative stimulator programming and patient c...
Identifying patient subtypes in multiple sclerosis and tailoring immunotherapy: challenges for the future [0.03%]
识别多发性硬化症患者亚型及量身定制免疫治疗：未来面临的挑战
Philip L De Jager
Philip L De Jager
The accelerating pace of technological and analytical development in the fields of genetic and phenotypic profiling has ushered in an era of great promise for multiple sclerosis (MS) research. As we continue to identify modest but meaningfu...
Olaf Hoffman,R Joerg Weber
Olaf Hoffman
Bacterial meningitis is a medical emergency requiring immediate diagnosis and immediate treatment. Streptococcus pneumoniae and Neisseria meningitidis are the most common and most aggressive pathogens of meningitis. Emerging antibiotic resi...
Marco Mula,Bettina Schmitz
Marco Mula
In patients with epilepsy, mood disorders represent a frequent psychiatric comorbidity but they often remain unrecognized and untreated. However, comorbid depression may have a major impact on the quality of life of patients with epilepsy, ...
E Anne Macgregor
E Anne Macgregor
The development of diagnostic criteria has enabled greater recognition of menstrual migraine as a highly prevalent and disabling condition meriting specific treatment. Although few therapeutic trials have yet been undertaken in accordance w...
Evidence-based drug treatment in amyotrophic lateral sclerosis and upcoming clinical trials [0.03%]
基于循证的药物治疗在肌萎缩侧索硬化症中的应用及即将开展的临床试验
Albert C Ludolph,Sarah Jesse
Albert C Ludolph
Amyotrophic Lateral sclerosis/motor neuron disease is a severe neurodegenerative disease characterized by upper and Lower motor neuron degeneration for which there is no truly effective treatment. Several therapies have shown promise in pre...
Pedro Emilio Bermejo,Buenaventura Anciones
Pedro Emilio Bermejo
Although zonisamide was previously only used to treat epilepsy, recently more applications have been forthcoming. Due to a good side effect profile, a lower frequency of interactions and a more comfortable posology, there are several studie...