Cathérine C S Delnooz,Bart P C van de Warrenburg
Cathérine C S Delnooz
Dystonia is a hyperkinetic movement disorder, characterized by involuntary and sustained contractions of opposing muscles causing twisting movements and abnormal postures. It is often a disabling disorder that has a significant impact on ph...
Current and emerging therapies in multiple sclerosis: a systematic review [0.03%]
多发性硬化症的当前和新兴疗法：系统评价
Wanda Castro-Borrero,Donna Graves,Teresa C Frohman et al.
Wanda Castro-Borrero et al.
Multiple sclerosis (MS) is a potentially disabling chronic autoimmune neurological disease that mainly affects young adults. Our understanding of the pathophysiology of MS has significantly advanced in the past quarter of a century. This ha...
Extended-release dalfampridine in the management of multiple-sclerosis-related walking impairment [0.03%]
extended-release dalfampridine在多发性硬化症步行障碍管理中的应用
Carrie Hersh,Alex Rae-Grant
Carrie Hersh
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system that causes neurological impairment in young adults. As part of the disease, ambulation remains one of the most disabling features of multiple scleros...
Relationship between 25-OH-D serum level and relapse rate in multiple sclerosis patients before and after vitamin D supplementation [0.03%]
补充维生素D前后维生素D缺乏和多发性硬化患者复发率的关系研究
Charles Pierrot-Deseilligny,Sophie Rivaud-Péchoux,Pierre Clerson et al.
Charles Pierrot-Deseilligny et al.
Background: Vitamin D could play a protective role in multiple sclerosis. Methods: In an observational, uncontrolled study, vitamin D3 ...
Tilman Wolter,Holger Kaube
Tilman Wolter
Neurostimulation techniques for the treatment of primary headache syndromes, particularly of chronic cluster headache, have received much interest in recent years. Occipital nerve stimulation (ONS) has yielded favourable clinical results an...
Nelvys Subirós,Diana García Del Barco,Rosa M Coro-Antich
Nelvys Subirós
Acute stroke is one of the major causes of death and disabilities. Since the 1980s many clinical studies have been conducted to evaluate neuroprotective approaches to treat this important brain vascular event. However, to date the only drug...
Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more [0.03%]
甘蛋白作为中枢神经系统炎症自身抗体作用靶点：髓鞘少突胶质细胞糖蛋白等
Marie Cathrin Mayer,Edgar Meinl
Marie Cathrin Mayer
B cells and antibodies constitute an important element in different inflammatory diseases of the central nervous system (CNS). Autoantibodies can serve as a biomarker to identify disease subgroups and may in addition contribute to the patho...
Silvia N Tenembaum
Silvia N Tenembaum
Children and adolescents with multiple sclerosis (MS) are reported to show high rates of relapse early in the course of the disease as well as cognitive deterioration over time. Immunomodulatory therapies developed for adult MS patients are...
Jan Kassubek,Albert C Ludolph,Hans-Peter Müller
Jan Kassubek
It is agreed that conventional magnetic resonance imaging (MRI) of the brain and spine is one of the core elements in the differential diagnostic work up of patients with clinical signs of motor neuron diseases (MNDs), for example amyotroph...
Health-related quality of life as an outcome variable in Parkinson's disease [0.03%]
帕金森病的健康相关生活质量结局变量研究
Pablo Martinez-Martin,Mónica M Kurtis
Pablo Martinez-Martin
In the past three decades, health-related quality of life (HRQoL) has become an outcome variable in Parkinson's disease clinical trials. This review considers the measuring tools that have been developed, suitability of data reporting, comp...