Possible clinical outcome measures for clinical trials in patients with multiple sclerosis [0.03%]
可能作为多发性硬化症患者临床试验结果的临床结局指标
Myla D Goldman,Robert W Motl,Richard A Rudick
Myla D Goldman
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease with both clinical and pathological heterogeneity. The complexity of the MS population has offered challenges to the measurement of MS disease progression in th...
Angelo Ghezzi
Angelo Ghezzi
Multiple sclerosis (MS) in children and adolescents accounts for 3-10% of the whole MS population, and is characterized by a relapsing course in almost all cases. The frequency of relapses is higher than in adult onset MS, at least in the f...
Hans-Peter Hartung,Bernd C Kieseier
Hans-Peter Hartung
Multiple sclerosis (MS) has traditionally been considered to be a T-cell-mediated disease. However, there is an increasing body of evidence for the involvement of B cells and autoantibodies in the pathology of this disease, providing a rati...
Hypothalamic deep brain stimulation in the treatment of chronic cluster headache [0.03%]
丘脑深部电刺激治疗慢性丛集性头痛
Massimo Leone,Angelo Franzini,Alberto Proietti Cecchini et al.
Massimo Leone et al.
Cluster headache (CH) is a short-lasting unilateral headache associated with ipsilateral craniofacial autonomic manifestations. A positron emission tomography (PET) study has shown that the posterior hypothalamus is activated during CH atta...
Douglas M Sproule,Petra Kaufmann
Douglas M Sproule
Spinal muscular atrophy (SMA), a potentially devastating disease marked by progressive weakness and muscle atrophy resulting from the dysfunction and loss of motor neurons of the spinal cord, has emerged in recent years as an attractive tar...
Reversible cerebral vasoconstriction syndrome: an under-recognized clinical emergency [0.03%]
可逆性脑血管收缩综合征：一种被忽视的临床急症
Shih-Pin Chen,Jong-Ling Fuh,Shuu-Jiun Wang
Shih-Pin Chen
Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by recurrent thunderclap headaches and reversible cerebral vasoconstrictions. RCVS is more common than previously thought and should be differentiated from aneurismal sub...
Optical coherence tomography as a potential readout in clinical trials [0.03%]
光学相干断层扫描作为临床试验的潜在结果指标
Benjamin M Greenberg,Elliot Frohman
Benjamin M Greenberg
Optical coherence tomography (OCT) is a noninvasive tool used for measuring tissue at micrometer resolution. It has been extensively applied to ocular pathologies and is now being studied as a biomarker in various neurologic conditions. The...
Matthew A Wozniak,Ruth F Itzhaki
Matthew A Wozniak
A preclinical trial of sialic acid metabolites on distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy, a sugar-deficient myopathy: a review [0.03%]
岩藻糖残积物远端肌病/遗传性包涵体肌病的神经氨酸代谢物临床前试验：综述
May Christine V Malicdan,Satoru Noguchi,Ichizo Nishino
May Christine V Malicdan
Distal myopathy with rimmed vacuoles (DMRV), also called hereditary inclusion body myopathy (hIBM), is a moderately progressive hereditary muscle disorder affecting young adults. DMRV/hIBM is characterized clinically by muscle atrophy and w...
Tiago Mestre,Joaquim J Ferreira
Tiago Mestre
Parkinson's disease is a common neurodegenerative disorder with the particular feature of having various available treatments with proven efficacy. However, no treatment is curative. Recent trial results provided data for the discussion abo...