Associating functional groups to multiple clinical types using combined t-test scores and contingency-based measures: a study on breast cancer genes [0.03%]
结合t检验分数和关联矩阵的乳腺癌基因多重临床类型的功能团属性分析研究
Noha A Yousri,Dalal M Elkaffash
Noha A Yousri
Stemming from the need to score relations between functional groups of genes and multiple clinical types associated with a tumour, this study proposes to use contingency-based measures to quantify such relations. It aims at reflecting a rel...
Functional classification of genes using semantic distance and fuzzy clustering approach: evaluation with reference sets and overlap analysis [0.03%]
基于语义距离和模糊聚类方法的功能基因分类：参考数据集及重叠分析评估
Marie-Dominique Devignes,Sidahmed Benabderrahmane,Malika Smaïl-Tabbone et al.
Marie-Dominique Devignes et al.
Functional classification aims at grouping genes according to their molecular function or the biological process they participate in. Evaluating the validity of such unsupervised gene classification remains a challenge given the variety of ...
Functional identification in correlation networks using gene ontology edge annotation [0.03%]
基于Gene Ontology注释的关联网络中的功能鉴定
Kathryn Dempsey,Ishwor Thapa,Dhundy Bastola et al.
Kathryn Dempsey et al.
Correlation networks identify mechanisms behind observed change in temporal data sets; however, it is often difficult to discriminate between causative versus coincidental structures in such networks. We propose a method to enhance causativ...
Identification of disease-related nsSNPs via the integration of protein sequence features and domain-domain interaction data [0.03%]
基于蛋白质序列特征和结构域-结构域相互作用数据的疾病相关nsSNP识别方法
Rui Jiang,Mingxin Gan,Jiaxin Wu
Rui Jiang
Recent studies have suggested the common disease-rare variant (CD-RV) hypothesis in the mapping of disease-related genetic variants and have proposed a number of statistical methods to detect associations between rare variants and human inh...
Network-based approaches for extending the Wnt signalling pathway and identifying context-specific sub-networks [0.03%]
基于网络的Wnt信号通路扩展及识别特定情境亚路径的方法研究
Sudipto Saha,Theodore Roman,Alex Galante et al.
Sudipto Saha et al.
Wnt signalling is a critically important signalling pathway regulating embryogenesis and differentiation, and is broadly conserved amongst multicellular animals. In addition, dysregulation of Wnt signalling contributes to the pathogenesis o...
Systems biology approaches in biological and biomedical research: opportunities and challenges [0.03%]
系统生物学在生物和医学研究中的机会与挑战
Zhongming Zhao,Rui Jiang,Huiru Zheng
Zhongming Zhao
Genome wide search for identification of potential drug targets in Bacillus anthracis [0.03%]
全基因组寻找Bacillus anthracis潜在药物作用靶点
Ravi V Gutlapalli,Jyothsna L Ambaru,Pavani Darla et al.
Ravi V Gutlapalli et al.
With the heightened interest in Bacillus anthracis as a potential biological threat agent, novel drug targets identification is of great importance in drug discovery. This study considered a genome-wide approach to identify 270 non-redundan...
Development of an integrated network visualisation and graph analysis tool for biological networks [0.03%]
一种综合的网络可视化和图分析工具的开发用于生物网络
Ying Tang,David Carbonetta,Sachin Shetty
Ying Tang
There has been a steady increase in the amount of molecular data generated by experiments and computational methods performed on biological networks. There is a growing need to obtain an insight into the organisation and structure of the ma...
Nikhil Gadewal,Ashok Varma
Nikhil Gadewal
Dysregulation of Pim-1 kinase has been implicated in several human cancers. Many potential inhibitors of PIM kinase have been reported, but potential bioactive compounds are still far from reach. Keeping this in mind, we have selected struc...
3D QSAR CoMFA/CoMSIA and docking studies on azole dione derivatives, as anti-cancer inhibitors [0.03%]
azole二酮衍生物抗肿瘤抑制剂的3D-QSAR-CoMFA/CoMSIA及对接研究
Rohith Kumar Anugolu,Shravan Kumar Gunda,Shaik Mahmood
Rohith Kumar Anugolu
Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) were performed on a series of 103 azole dione derivatives, as selective anti-cancer inhibitors. The atom and shape based root mean s...