Fan Zhang,Michael D Kuo
Fan Zhang
The human evolution and cancer evolution have been researched for several years, but little is known about the molecular similarities between human and cancer evolution. One interesting and important question when comparing and analyzing hu...
Identifying the dynamic gene regulatory network during latent HIV-1 reactivation using high-dimensional ordinary differential equations [0.03%]
利用高维常微分方程识别潜伏HIV-1再激活期间的动态基因调控网络
Jaejoon Song,Michelle Carey,Hongjian Zhu et al.
Jaejoon Song et al.
Reactivation of latently infected cells has emerged as an important strategy for eradication of HIV. However, genetic mechanisms of regulation after reactivation remain unclear. We describe a five-step pipeline to study the dynamics of the ...
PATH: An interactive web platform for analysis of time-course high-dimensional genomic data [0.03%]
PATH：一个用于分析时间序列高维基因组数据的互动式网络平台
Yuping Zhang,Yang Chen,Zhengqing Ouyang
Yuping Zhang
Discovering patterns in time-course genomic data can provide insights on the dynamics of biological systems in health and disease. Here, we present a Platform for Analysis of Time-course High-dimensional data (PATH) with applications in gen...
Modelling of hypoxia gene expression for three different cancer cell lines [0.03%]
三种不同癌细胞系的低氧基因表达谱的建模分析
Babak Soltanalizadeh,Erika Gonzalez Rodriguez,Vahed Maroufy et al.
Babak Soltanalizadeh et al.
Gene dynamic analysis is essential in identifying target genes involved pathogenesis of various diseases, including cancer. Cancer prognosis is often influenced by hypoxia. We apply a multi-step pipeline to study dynamic gene expressions in...
Brain-wide structural connectivity alterations under the control of Alzheimer risk genes [0.03%]
阿尔茨海默病风险基因控制下的全脑结构连接改变
Jingwen Yan,Vinesh Raja V,Zhi Huang et al.
Jingwen Yan et al.
Background: Alzheimer's disease is the most common form of brain dementia characterized by gradual loss of memory followed by further deterioration of other cognitive function. Large-scale genome-wide association studies ...
Native State of Complement Protein C3d Analysed via Hydrogen Exchange and Conformational Sampling [0.03%]
氢交换和构象采样分析补体蛋白C3d的天然状态
Didier Devaurs,Malvina Papanastasiou,Dinler A Antunes et al.
Didier Devaurs et al.
Hydrogen/deuterium exchange detected by mass spectrometry (HDXMS) provides valuable information on protein structure and dynamics. Although HDX-MS data is often interpreted using crystal structures, it was suggested that conformational ense...
Inference of hierarchical regulatory network of TCF7L2 binding sites in MCF7 cell line [0.03%]
TCF7L2结合位点在MCF7细胞系中的层次化调控网络的推断
Yao Wang,Rui Wang,Victor X Jin
Yao Wang
The TCF7L2 transcription factor (TF) is a member of Wnt signalling pathway, and may influence transcription of several genes by binding to distinct regulatory regions. Genome-wide studies have identified thousands of TCF7L2 binding sites an...
A Framework for 3D Vessel Analysis using Whole Slide Images of Liver Tissue Sections [0.03%]
基于组织切片全视野图像的三维血管分析框架
Yanhui Liang,Fusheng Wang,Darren Treanor et al.
Yanhui Liang et al.
Three-dimensional (3D) high resolution microscopic images have high potential for improving the understanding of both normal and disease processes where structural changes or spatial relationship of disease features are significant. In this...
Mohit M Jain,Nirmala Kumari,Geeta Rai
Mohit M Jain
LXR (encoded by NR1H2 and 3) and FXR (known as bile acid receptor) encoded by NR1H4 (nuclear receptor subfamily 1, group H and member 4) are nuclear receptors in humans and are important regulators of bile acid production, cholesterol, fatt...
In silico phylogenetic analysis of Vibrio cholerae isolates based on three housekeeping genes [0.03%]
基于3个管家基因的霍乱弧菌分离株的系统发育分析
Tayebeh Farhadi,Navid Nezafat,Younes Ghasemi
Tayebeh Farhadi
Vibrio cholera, a gram-negative bacterium, has been categorised into clinical and environmental species. Phylogenetic studies have been performed to investigate the relationships of the V. cholerae populations in worldwide. In this study, p...