Vikram Kalluru,Raghu Machiraju,Kun Huang
Vikram Kalluru
Since co-expressed genes often are co-regulated by a group of transcription factors, different conditions (e.g. disease versus normal) may lead to different transcription factor activities and therefore different co-expression networks. We ...
Adeshola A Adefioye,Xinhai Liu,Bart De Moor
Adeshola A Adefioye
Clustering is an unsupervised method that allows researchers to group objects and gather information about their relationships. In chemoinformatics, clustering enables hypotheses to be drawn about a compound's biological, chemical and physi...
An iterative searching and ranking algorithm for prioritising pharmacogenomics genes [0.03%]
一种用于药物基因组学基因优先排序的迭代搜索和排名算法
Rong Xu,Quanqiu Wang
Rong Xu
Pharmacogenomics (PGx) studies are to identify genetic variants that may affect drug efficacy and toxicity. A machine understandable drug-gene relationship knowledge is important for many computational PGx studies and for personalised medic...
A new iterative method to reduce workload in systematic review process [0.03%]
一种新的迭代方法以减少系统评价过程中的劳动量
Siddhartha Jonnalagadda,Diana Petitti
Siddhartha Jonnalagadda
High cost for systematic review of biomedical literature has generated interest in decreasing overall workload. This can be done by applying natural language processing techniques to 'automate' the classification of publications that are po...
Zhongming Zhao,Hua Xu,Bing Zhang et al.
Zhongming Zhao et al.
Fourth generation detour matrix-based topological indices for QSAR/QSPR - part-1: development and evaluation [0.03%]
基于拓扑指数的QSAR/QSPR研究（第一部分）：发展与评价
Rakesh Kumar Marwaha,Harish Jangra,Kinkar C Das et al.
Rakesh Kumar Marwaha et al.
In the present study, four detour matrix-based Topological Indices (TIs) termed as augmented path eccentric connectivity indices 1-4 (denoted by (AP)ξ(1)(C), (AP)ξ(2)(C), (AP)ξ(3)(C) and (AP)ξ(4)(C)) as well as their topochemical versio...
Peptide sequence tag generation for tandem mass spectra containing post-translational modifications [0.03%]
含翻译后修饰的串联质谱肽序列标签生成方法研究
Hui Li,Chunmei Liu
Hui Li
Tandem mass spectrometry is a popular tool for the identification of peptide sequences. In this paper, we present a method for a rapid generation of short peptide sequences via tandem mass spectrometry based on a graph search method. The ap...
Identification of two post-translational modifications via tandem mass spectrometry [0.03%]
通过串联质谱鉴定两种翻译后修饰
Hui Li,Chunmei Liu,Legand Burge et al.
Hui Li et al.
Post-Translational Modifications (PTMs) play most important roles in the accomplishment of biological processes and molecular functions. It is challenging to identify two PTMs for a tandem mass spectrum. In this paper, we proposed a new alg...
Integrating image analysis algorithms in a web interface for the quantification of microtubule dynamics [0.03%]
一种网络界面定量微管动力学的图像分析算法集成方法
Koon Yin Kong,Adam I Marcus,Paraskevi Giannakakou et al.
Koon Yin Kong et al.
We present improvements to a web interface and an integrated computational tracking algorithm for quantitative analysis of microtubule dynamics in live-cell microscopy images. Based on a previously implemented system, more new functionaliti...
A linear-time algorithm for finding a maximum-length ORF in a splice graph [0.03%]
.splice图中寻找最长ORF的线性时间算法
Jerzy W Jaromczyk,Neil Moore,Christopher L Schardl
Jerzy W Jaromczyk
We present a linear-time, deterministic algorithm for finding a longest Open Reading Frame (ORF) in an alternatively spliced gene represented by a splice graph. Finding protein-encoding regions is a fundamental problem in genomic and transc...