Characterisation of the flexibility of substrate binding loop in the binding of direct InhA inhibitors [0.03%]
底物结合环的柔性及其与结核分枝杆菌InhA直接抑制剂结合的关系研究
Vivek Kumar,M Elizabeth Sobhia
Vivek Kumar
The substrate binding loop (SBL) of inhA shows conformational changes on binding of direct inhA inhibitors (DIIs). The knowledge of conformational changes and its importance in binding of DII to inhA has not been explored before. This study...
Models for the prediction of melanocortin-4 receptor agonist activity of 4-substituted piperidin-4-ol [0.03%]
4-取代的哌啶-4-醇类麦角皮质激素-4受体激动剂活性的预测模型研究
Monika Gupta,A K Madan
Monika Gupta
In the present study both classification and correlation techniques have been successfully employed for the development of the models of diverse nature for the prediction of melanocortin 4-receptor (MC4 R) agonist activity using a dataset c...
An evaluation of allele frequency estimation accuracy using pooled sequencing data [0.03%]
基于混合序列数据的等位基因频率估算精度评估
Yan Guo,Qiuyin Cai,Chun Li et al.
Yan Guo et al.
Next generation sequencing technology has matured, and with its current affordability, will replace the SNP chip as the genotyping tool of choice. Even with the current affordability of NGS, large scale studies will require careful study de...
Haydar A Mahmood,Nazeih M Botros
Haydar A Mahmood
The goal of this study is to develop a synthesisable computer-simulated model that mimics the function of a simplified renal system. Hardware description language has been used to simulate the model. In future phase of this study, the model...
Cleveland E Rayford nd,Weihua Zhou,Ying Chen
Cleveland E Rayford nd
Traditional two-dimensional (2D) X-ray mammography is the most commonly used method for breast cancer diagnosis. Recently, a three-dimensional (3D) Digital Breast Tomosynthesis (DBT) system has been invented, which is likely to challenge th...
Performance of chemical shift-based water-fat separation with self-calibrated fat spectrum is sensitive to echo times [0.03%]
基于自校正脂肪谱的化学移相水脂分离性能受回波时间影响
Xinwei Shi,Hua Guo
Xinwei Shi
Chemical shift-based water-fat separation method utilises water-fat resonance frequency difference to decompose signals into water and fat partitions in magnetic resonance imaging (MRI) on a pixel-wise basis. It provides an effective way to...
Colony size optimisation in colony-based laser imaging for microbial source tracking [0.03%]
基于菌落的激光成像法中菌落大小优化在微生物追踪中的应用
Hao Gong,Bin Chen,Xu Zhang et al.
Hao Gong et al.
The colony-based laser scatter imaging provides a convincing solution to microbial source tracking. The optical scattering patterns of bacterial colonies are tightly correlated to the corresponding growth patterns. This relationship is mani...
A contrast enhancement filter for improving stent visibility in interventional X-ray fluoroscopy: an initial study [0.03%]
一种可提高介入放射荧光透视中支架可见度的对比增强滤波器的初步研究
Yuhao Jiang,Ling-Hsiao Chang
Yuhao Jiang
Low exposure X-ray fluoroscopy is widely used to guide some complicate interventional procedures. Given its inherent high noise, improving the visibility of interventional devices such as stents will greatly benefit the procedures. In this ...
Effects of key parameters of impulse noise on prediction of the auditory hazard using AHAAH model [0.03%]
脉冲噪声关键参数对听觉危害预测的影响研究——基于AHAAH模型
Qing Wu,Jun Qin
Qing Wu
Noise-Induced Hearing Loss (NIHL) is the most common occupational disease in the USA. Impulse noise is a typical noise exposure in military and industrial fields, and generates severe hearing loss problem in these fields. This paper present...
Functional MR image statistical restoration for neural activity detection using Hidden Markov Tree model [0.03%]
基于隐马尔可夫树模型的功能性磁共振图像统计修复方法用于神经活动检测
Chuan Li,Qi Hao
Chuan Li
In this paper, we present a framework for functional MR image restoration based on the Hidden Markov Tree (HMT) model. Under this scheme, the wavelet/contourlet coefficients of the distorted image are filtered using the HMT model of the bas...