Classification of T cell movement tracks allows for prediction of cell function [0.03%]
T细胞运动轨迹的分类使其功能预测成为可能
Reka K Kelemen,Gengen F He,Hannah L Woo et al.
Reka K Kelemen et al.
Using a unique combination of visual, statistical, and data mining methods, we tested the hypothesis that an immune cell's movement pattern can convey key information about the cell's function, antigen specificity, and environment. We appli...
A comparison of microRNA sequencing reproducibility and noise reduction using mirVana and TRIzol isolation methods [0.03%]
mirVana和TRIzol分离方法对微小RNAs测序可重复性及噪声降低的比较分析
Yan Guo,Amma Bosompem,Xu Zhong et al.
Yan Guo et al.
MicroRNAseq (miRNAseq) is a form of RNAseq technology that has become an increasingly popular alternative to miRNA expression profiling. Unlike messenger RNA (mRNA), miRNA extraction can be difficult, and sequencing such small RNA can also ...
Zhongming Zhao,Bing Zhang,Yufei Huang et al.
Zhongming Zhao et al.
A study on druggability of MIA as a promising approach for inhibition of metastasis [0.03%]
针对MIA成药性的研究及其在抑制肿瘤转移中的作用探讨
Jamal Shamsara
Jamal Shamsara
MIA (Melanoma Inhibitory Activity) protein is over expressed in melanoma cells and binds to extracellular matrix proteins as well as to several integrins. These interactions were suggested to promote formation of metastasis. Therefore, abro...
Plant defence model revisions through iterative minimisation of constraint violations [0.03%]
通过迭代最小化约束Violation来修订植物防御模型
Dragana Miljkovic,Matjaž Depolli,Tjaša Stare et al.
Dragana Miljkovic et al.
Biologists have been investigating plant defence response to virus infections; however, a comprehensive mathematical model of this complex process has not been developed. One obstacle in developing a dynamic model, useful for simulation, is...
Optimisation of miRNA-mRNA relationship prediction using biological features [0.03%]
基于生物特征的miRNA-mRNA关系预测优化方法
Jasjit K Banwait,Hesham H Ali,Dhundy R Bastola
Jasjit K Banwait
MicroRNAs are small (approx. 22nt) non-coding RNAs that regulate the expression of genes by either degrading messenger-RNA (mRNA) that has already been transcribed or by repressing the translation of mRNA, thus inhibiting protein production...
Combining multiple clusterings of chemical structures using cluster-based similarity partitioning algorithm [0.03%]
基于相似分区的聚类算法组合化学结构的多种聚类结果
Faisal Saeed,Naomie Salim,Ammar Abdo
Faisal Saeed
Many types of clustering techniques for chemical structures have been used in the literature, but it is known that any single method will not always give the best results for all types of applications. Recent work on consensus clustering me...
Fourth generation detour matrix-based topological descriptors for QSAR/QSPR - Part-2: application in development of models for prediction of biological activity [0.03%]
用于预测生物活性的QSAR/QSPR模型的发展（二）：基于四代绕行矩阵拓扑描述符的方法
Rakesh Kumar Marwaha,A K Madan
Rakesh Kumar Marwaha
Augmented path eccentric connectivity topochemical indices (reported in part-1 of the manuscript) along with 42 diverse non-correlating molecular descriptors (shortlisted from a large pool of 2D and 3D MDs) were successfully utilised for th...
Sample size calculation for differential expression analysis of RNA-seq data under Poisson distribution [0.03%]
泊松分布下RNA测序数据差异表达分析的样本量计算方法研究
Chung-I Li,Pei-Fang Su,Yan Guo et al.
Chung-I Li et al.
Sample size determination is an important issue in the experimental design of biomedical research. Because of the complexity of RNA-seq experiments, however, the field currently lacks a sample size method widely applicable to differential e...
Multidrug resistance protein P-gp interaction with nanoparticles (fullerenes and carbon nanotube) to assess their drug delivery potential: a theoretical molecular docking study [0.03%]
理论分子对接研究多药耐药蛋白P-糖蛋白与纳米粒（富勒烯和碳纳米管）的相互作用以评估其药物递送潜力
Sergey Shityakov,Carola Förster
Sergey Shityakov
P-glycoprotein (P-gp)-mediated efflux system plays an important role to maintain chemical balance in mammalian cells for endogenous and exogenous chemical compounds. However, despite the extensive characterisation of P-gp potential interact...