P56(lck) kinase inhibitor studies: a 3D QSAR approach towards designing new drugs from flavonoid derivatives [0.03%]
基于黄酮类衍生物的LCK激酶抑制剂的三维定量结构活性关系研究及新药设计
Shravan Kumar Gunda,Sandeep Kumar Mulukala Narasimha,Mahmood Shaik
Shravan Kumar Gunda
Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) based on 3D-QSAR (3D-quantitative structure activity relationship) studies were carried out on 97 flavonoid derivatives as potent P5...
Automatic cell segmentation in strongly agglomerated cell networks for different cell types [0.03%]
不同类型细胞强聚集成像的自动分割算法
S Buhl,B Neumann,S C Schäfer et al.
S Buhl et al.
This paper presents a method of separating cells that are connected to each other forming clusters. The difference to many other publications covering similar topics is that the cell types we are dealing with form clusters of highly varying...
Jakob L Andersen,Christoph Flamm,Daniel Merkle et al.
Jakob L Andersen et al.
The chemical universe of molecules reachable from a set of start compounds by iterative application of a finite number of reactions is usually so vast, that sophisticated and efficient exploration strategies are required to cope with the co...
Supervised method for periodontitis phenotypes prediction based on microbial composition using 16S rRNA sequences [0.03%]
基于16S rRNA序列的牙周炎表型预测的监督方法
Wei Chen,Yong-Mei Cheng,Shao-Wu Zhang et al.
Wei Chen et al.
Microbes play an important role on human health, however, little is known on microbes in the past decades for the limitation of culture-based techniques. Recently, with the development of next-generation sequencing (NGS) technologies, it is...
Correcting imbalanced reads coverage in bacterial transcriptome sequencing with extreme deep coverage [0.03%]
利用极高深度测序数据校正细菌转录组测序中的读段覆盖偏差问题
Xinjun Zhang,Dharanesh Gangaiah,Robert S Munson Jr et al.
Xinjun Zhang et al.
High throughput bacterial RNA-Seq experiments can generate extremely high and imbalanced sequencing coverage. Over- or under-estimation of gene expression levels will hinder accurate gene differential expression analysis. Here we evaluated ...
Differential Shannon entropy and differential coefficient of variation: alternatives and augmentations to differential expression in the search for disease-related genes [0.03%]
差分香农熵和差分变异系数：寻找与疾病相关基因的差异表达替代方法及增强方法
Kai Wang,Charles A Phillips,Gary L Rogers et al.
Kai Wang et al.
Differential expression has been a standard tool for analysing case-control transcriptomic data since the advent of microarray technology. It has proved invaluable in characterising the molecular mechanisms of disease. Nevertheless, the exp...
Ramanandan Prabhakaran,Shivapriya Chithambaram,Xuhua Xia
Ramanandan Prabhakaran
The GC-rich bacterial species, Aeromonas salmonicida, is parasitised by both GC-rich phages (Aeromonas phages - phiAS7 and vB_AsaM-56) and GC-poor phages (Aeromonas phages - 25, 31, 44RR2.8t, 65, Aes508, phiAS4 and phiAS5). Both the GC-rich...
Localisation of Drosophila embryos using active contours in channel spaces [0.03%]
基于通道空间的活动轮廓模型在果蝇胚胎定位中的应用研究
Qi Li,Soujanya Siddavaram Ananta
Qi Li
In this paper, we introduce an active contour based scheme to localise Drosophila embryos in RGB images. An active contour (initiated as a closed one) maybe converge to an open contour, e.g., in the case that a targeting embryo is touched b...
The centrality of cancer proteins in human protein-protein interaction network: a revisit [0.03%]
致癌蛋白质在人类蛋白质相互作用网络中的中心性：重新审视
Wei Xiong,Luyu Xie,Shuigeng Zhou et al.
Wei Xiong et al.
Topological analysis of protein-protein interaction (PPI) networks has been widely applied to the investigation on cancer mechanisms. However, there is still a debate on whether cancer proteins exhibit more topological centrality compared t...
Vishal N Koparde,Ricky S Adkins,Jennifer M Fettweis et al.
Vishal N Koparde et al.
Bayesian-like operational taxonomic unit examiner (BOTUX) is a new tool for the classification of 16S rRNA gene sequences into operational taxonomic units (OTUs) that addresses the problem of overestimation caused by errors introduced durin...