Simulation of genomic recombination and the influence of DNA sequence diversity on cluster formation and detectability of recombination: a scientific workflow method [0.03%]
基因重组的模拟及其对DNA序列多样性、谱型形成和重组检测的影响：一种科学工作流方法
Jamal Alhiyafi,Shiyong Lu,Jeffrey L Ram
Jamal Alhiyafi
The detection of recombination from DNA sequences is relevant to the understanding of evolutionary and molecular genetics. We developed a Recombination Simulation Scientific Workflow System (RSSWS) for simulating recombination and using GEN...
Predicting multiple binding modes using a kernel method based on a vector space model molecular descriptor [0.03%]
基于向量空间模型分子描述符的核函数方法预测多重结合模式
Forbes J Burkowski,William W L Wong
Forbes J Burkowski
We describe the use of our Vector Space Model Molecular Descriptor (VSMMD), based on a Vector Space Model (VSM) that is suitable for kernel studies in Quantitative Structure-Activity Relationship (QSAR) modelling. Our experiments provide co...
Multiclass primal support vector machines for breast density classification [0.03%]
用于乳腺密度分类的多类原始支持向量机
Walker H Land Jr,Elizabeth A Verheggen
Walker H Land Jr
Parenchymal patterns defining the density of breast tissue are detected by advanced correlation pattern recognition in an integrated Computer-Aided Detection (CAD) and diagnosis system. Fractal signatures of density are modelled according t...
Identification of condition-specific regulatory modules through multi-level motif and mRNA expression analysis [0.03%]
基于多层调控元件和基因表达分析鉴定特定生物学条件下活性的共表达模块
Li Chen,Jianhua Xuan,Yue Wang et al.
Li Chen et al.
Many computational methods for identification of transcription regulatory modules often result in many false positives in practice due to noise sources of binding information and gene expression profiling data. In this paper, we propose a m...
Nathan E Wineinger,Richard E Kennedy,Stephen W Erickson et al.
Nathan E Wineinger et al.
Approaches to assess copy number variation have advanced rapidly and are being incorporated into genetic studies. While the technology exists for CNV genotyping, a further understanding and discussion of how to use the CNV data for associat...