Perfusion and Structural Impairment in Minor Stroke and Transient Ischemic Attack With Intracranial Atherosclerotic Stenosis: Associations With Cognitive Decline [0.03%]
轻型卒中和短暂性脑缺血发作患者颅内动脉粥样硬化狭窄的灌注及结构异常与认知功能下降的关系
Meiling Shang,Gezhi Yan,Wanghuan Dun et al.
Meiling Shang et al.
Aims: To investigate the characteristics of hypoperfusion and structural impairment in patients with transient ischemic attack (TIA) or minor stroke (MS) with intracranial atherosclerotic stenosis (ICAS) and evaluate its ...
Cellular Communication Networks Mediated by Microglia in Ischemic Stroke [0.03%]
缺血性卒中微胶质细胞介导的细胞通讯网络研究进展
Feiyu Ma,Yi Bai,Na Li et al.
Feiyu Ma et al.
Introduction: Microglia, the resident immune cells of the central nervous system, rapidly activate after ischemic stroke and actively communicate with neurons, astrocytes, endothelial cells, and infiltrating peripheral im...
Electroacupuncture Prevents Against AD-Like Phenotypes in APP/PS1 Mice: Investigation of the Mechanisms From Cerebral Microangiopathy [0.03%]
电针通过改善脑微血管病变防治APP/PS1双转基因小鼠AD-like表型的作用机制研究
Chen Yang,Baobao Li,Shaojie Yang et al.
Chen Yang et al.
Background: Electroacupuncture (EA) has been widely used in Alzheimer's disease (AD) treatment. However, its underlying mechanisms remain poorly elucidated. ...
Amyloid Beta in Alzheimer's Disease: Mechanisms, Biomarker Potential, and Therapeutic Targets [0.03%]
阿尔茨海默病中的淀粉样蛋白β：机制、生物标志物潜力及治疗靶点
Shamseddin Ahmadi,Shiler Khaledi,Kimia Ahmadi et al.
Shamseddin Ahmadi et al.
Main problems: The accumulation of amyloid beta (Aβ) plaques and neurofibrillary tangles (NFTs) composed of Tau protein is two characteristic brain pathologies in Alzheimer's disease (AD). However, the Aβ hypothesis has...
Da-Bu-Yin-Wan and Qian-Zheng-San Alleviate Parkinson's Disease by Activating the Keap1/Nrf2/HO-1 Pathway to Positively Regulate Oxidative Stress [0.03%]
达布依宛和千贞散通过激活Keap1/Nrf2/HO-1途径积极调节氧化应激来缓解帕金森病
Huimin Zhu,Zijian Liu,Jing Feng et al.
Huimin Zhu et al.
Background: Parkinson's disease (PD) is a neurodegenerative disorder that worsens progressively. Different pathological mechanisms are involved in the progression of PD, including the loss of dopaminergic (DA) neurons and...
NOD1/RIP2 Pathway Promotes Glioma Progression Through Microglial M2 Polarization [0.03%]
NOD1/RIP2通路通过小胶质细胞M2极化促进胶质瘤进展
Yuxue Luan,Miao Yu,Haimo Zhang et al.
Yuxue Luan et al.
Background and aim: Glioma is a highly aggressive malignancy of the central nervous system with a poor prognosis. The nucleoside-binding oligomerization domain-containing protein 1 (NOD1)/receptor-interacting protein 2 (R...
Decoding the Therapeutic Effects of Acupuncture in Hemorrhagic Stroke Using Single-Cell RNA Sequencing [0.03%]
运用单细胞RNA测序技术解码针刺治疗出血性中风的作用机制
Chen Ruan,Jia Du,Wentao Zhang et al.
Chen Ruan et al.
Background: Acupuncture has been proposed as a therapeutic intervention for stroke recovery, yet the underlying molecular mechanisms remain poorly understood. ...
Phase 2 Trial of PD-1 Inhibitor Sintilimab in Recurrent/Progressive Meningioma [0.03%]
抗PD-1单克隆抗体信迪利单抗治疗复发/进展脑膜瘤的Ⅱ期临床试验
Yali Wang,Can Wang,Shuo Yin et al.
Yali Wang et al.
Background: Systemic therapeutic options for meningiomas remain limited. Emerging evidence indicates meningiomas harbor an immunosuppressive microenvironment and programmed cell death ligand 1 (PD-L1) expression is signif...
Clinical Trial
CNS neuroscience & therapeutics. 2025 Dec;31(12):e70659. DOI:10.1111/cns.70659 2025
Mfsd2a-Targeted Therapy for Ischemic Stroke: Mechanisms, Evidence, and Future Prospects [0.03%]
缺血性卒中靶向Mfsd2a治疗：机制、证据与未来展望
Zhidong He,Jing Sun
Zhidong He
Background: Ischemic stroke remains a major cause of global disability and mortality, with blood-brain barrier (BBB) dysfunction being a pivotal event in its pathology. Major facilitator superfamily domain-containing 2a (...
Motor Intention Quantization for Patients With Disorders of Consciousness by Multimodal BCI Combining Electroencephalography and Functional Near-Infrared Spectroscopy [0.03%]
结合脑电和功能近红外光谱的多模态脑机接口在意识障碍患者意图量化中的应用研究
Nan Wang,Xiaoke Chai,Jiuxiang Song et al.
Nan Wang et al.
Objective: The current application of single-modality electroencephalography (EEG) or functional near-infrared spectroscopy (fNIRS) to assess consciousness levels in patients with disorders of consciousness (DoC) has garn...