Sestrin2 Mitigates Neuronal Ferroptosis Following Subarachnoid Hemorrhage via Orchestration of the AMPK/PGC1α/Nrf2 Signaling Axis [0.03%]
Yi Zhang,Xichen Wan,Hongyan Zhang et al.
Yi Zhang et al.
Background: Early brain injury after subarachnoid hemorrhage (SAH) involves oxidative stress and ferroptosis. Sestrin2 (SESN2) regulates redox homeostasis, but its role in SAH-induced ferroptosis remains unclear. ...
HBO-PC Reprograms Neuroimmune Metabolism Through Disruption of the LRG1-HIF-1α-IL-6-STAT3 Amplification Loop Attenuates Pyroptosis and Ischemia-Reperfusion Injury [0.03%]
Wenying Lv,Junzhe Lv,Kexin Xiong et al.
Wenying Lv et al.
Background: Neuroinflammation and pyroptosis driven by excessive microglial activation play key roles in cerebral ischemia-reperfusion injury (CIRI). Hyperbaric oxygen preconditioning (HBO-PC) exhibits neuroprotective eff...
Antithrombotic Therapy After Intracerebral Hemorrhage: Real-World Evidence for In-Hospital Resumption [0.03%]
Shengde Li,Tian Qu,Xiang Zhou et al.
Shengde Li et al.
Background and purpose: Patients with intracerebral hemorrhage (ICH) who require antithrombotic therapy (AT) face competing risks of recurrent bleeding and ischemic events. Optimal timing of AT resumption during hospitali...
AS1842856 Reduces β-Amyloid Burden via Inhibiting PLA2G4A-Mediated Lysosomal Dysfunction in APP/PS1 Mice [0.03%]
Da-Long He,Zheng Wu,Rong-Jun Jia et al.
Da-Long He et al.
Aims: Both cytosolic phospholipase A2 (PLA2G4A)-induced lysosomal membrane disruption and glycogen synthase kinase-3α/β (GSK3α/β)-mediated lysosomal dysfunction have been implicated in neurodegeneration, with a potent...
Identification of a Novel Radiosensitivity-Related Signature and Validation of GPX8 in Regulating the Radiosensitivity of Glioma [0.03%]
Gan Tao,Xiuli Guo,Fajian He et al.
Gan Tao et al.
Background: Radioresistance is fundamental to glioma progression and poor prognosis. Understanding its underlying mechanisms and identifying novel therapeutic targets through elucidating key molecules in glioma radiosensi...
CircRbfox1 Contributes to Colonic Hypersensitivity in Rats With Diabetes by Altering HuC Subcellular Localization to Regulate RBFOX1 Expression [0.03%]
Shiyu Zhang,Ji Hu,Chendong Ni et al.
Shiyu Zhang et al.
Aims: The purpose of this study was to explore the molecular mechanism of circRNA mediated colonic hypersensitivity in rats with diabetes. Methods: ...
Chenchen Xu,Xiaoxiao Li,Nan Cheng et al.
Chenchen Xu et al.
Objective: Following ischemic stroke (IS), activated microglia activity could contribute to neuronal injury and blood-brain barrier (BBB) disruption. The upstream vascular-derived signal initiating this transition remains...
High-Intensity Alternating Current Stimulation as an Add-On to Multidisciplinary Intensive Rehabilitation for Parkinson's Disease: A Randomized Controlled Trial [0.03%]
Ting-Ting Hou,Hong-Yu Zhang,Ke-Ke Chen et al.
Ting-Ting Hou et al.
Aims: In this randomized, double-blind, sham-controlled trial, we explored whether high-intensity transcranial alternating current stimulation (Hi-tACS), as an add-on to multidisciplinary intensive rehabilitation therapy ...
Randomized Controlled Trial
CNS neuroscience & therapeutics. 2026 Apr;32(4):e70909. DOI:10.1002/cns.70909 2026
Whole-Brain Neural Connectivity to Cholinergic Neurons in the Lower Thoracic Intermediolateral Column [0.03%]
Yuan-Jun Yang,Kai-Ying Zhang,Bin-Bin Li et al.
Yuan-Jun Yang et al.
Objective: The intermediolateral column (IML) serves as a crucial hub for sympathetic information processing between the brain and peripheral organs, with its defining hallmark being the presence of cholinergic neurons ex...
Development of a Novel Prognostic Inflammation Index to Predict Poor Outcomes in Patients With Intracerebral Hemorrhage: A Longitudinal Study [0.03%]
Guangyong Chen,Feng Chen,Xin Lu et al.
Guangyong Chen et al.
Background: Spontaneous intracerebral hemorrhage (ICH) is an acute cerebrovascular disease associated with high mortality and severe disability. Inflammation plays a critical role in the onset and progression of ICH. Howe...