Mimicry of the proton wire mechanism of enzymes inside a supramolecular capsule enables β-selective O-glycosylations [0.03%]
超分子胶囊内的酶质子信使机制的模拟实现β-选择性O-糖基化反应
Tian-Ren Li,Fabian Huck,GiovanniMaria Piccini et al.
Tian-Ren Li et al.
Enzymes achieve high substrate and product selectivities by orientating and activating the substrate(s) appropriately inside a confined and finely optimized binding pocket. Although some basic aspects of enzymes have already been mimicked s...
Light-activated tetrazines enable precision live-cell bioorthogonal chemistry [0.03%]
光激活的四嗪能使活细胞生物正交化学反应更精确
Luping Liu,Dongyang Zhang,Mai Johnson et al.
Luping Liu et al.
Bioorthogonal cycloaddition reactions between tetrazines and strained dienophiles are widely used for protein, lipid and glycan labelling because of their extremely rapid kinetics. However, controlling this chemistry in the presence of livi...
Stefan Borsley,David A Leigh,Benjamin M W Roberts
Stefan Borsley
Chemical reaction networks that transform out-of-equilibrium 'fuel' to 'waste' are the engines that power the biomolecular machinery of the cell. Inspired by such systems, autonomous artificial molecular machinery is being developed that fu...
Prebiotic synthesis and triphosphorylation of 3'-amino-TNA nucleosides [0.03%]
3'-氨基-TNA核苷的前生物合成和三磷酸化反应
Daniel Whitaker,Matthew W Powner
Daniel Whitaker
Nucleosides are essential to the emergence of life, and so their synthesis is a key challenge for prebiotic chemistry. Although amino-nucleosides have enhanced reactivity in water compared with ribonucleosides, they are assumed to be prebio...
Ferdinand C Grozema
Ferdinand C Grozema
Thomas Pillow
Thomas Pillow
Making nucleic acid monomers [0.03%]
制造核酸单体
Yingyu Liu,Yajun Wang
Yingyu Liu
Heart of glass [0.03%]
玻璃心
Michelle Francl
Michelle Francl
Lucas J Karas,Judy I Wu
Lucas J Karas
This year marks the 50th anniversary of Baird’s rules of aromaticity — a set of perturbational molecular orbital theory analyses that has garnered considerable attention in the past ten years in light of its many real-world applications i...
Ionic liquids charge ahead [0.03%]
离子液体大有前景
Eden E L Tanner
Eden E L Tanner