Bifunctional sulfilimines enable synthesis of multiple N-heterocycles from alkenes [0.03%]
双功能亚磺酰亚胺促进烯烃合成多种N-杂环化合物
Qiang Cheng,Zibo Bai,Srija Tewari et al.
Qiang Cheng et al.
Intramolecular cyclization of nitrogen-containing molecules onto pendant alkenes is an efficient strategy for the construction of N-heterocycles, which are of paramount importance in, for example, pharmaceuticals and materials. Similar inte...
N2O revalorization [0.03%]
硝酸氮的再利用价值
Jun-Jie Chen,Huan-Ming Huang
Jun-Jie Chen
A general design of caging-group-free photoactivatable fluorophores for live-cell nanoscopy [0.03%]
一种用于活细胞纳米显微镜的不含封闭基团的光激活荧光团的设计方法
Richard Lincoln,Mariano L Bossi,Michael Remmel et al.
Richard Lincoln et al.
The controlled switching of fluorophores between non-fluorescent and fluorescent states is central to every super-resolution fluorescence microscopy (nanoscopy) technique, and the exploration of radically new switching mechanisms remains cr...
Exploiting the sp2 character of bicyclo[1.1.1]pentyl radicals in the transition-metal-free multi-component difunctionalization of [1.1.1]propellane [0.03%]
利用[1.1.1]丙烷轮金属自由多组分双官能团化中的sp2性质二环[1.1.1]戊基自由基
Weizhe Dong,Expédite Yen-Pon,Longbo Li et al.
Weizhe Dong et al.
Strained bicyclic substructures are increasingly relevant in medicinal chemistry discovery research because of their role as bioisosteres. Over the last decade, the successful use of bicyclo[1.1.1]pentane (BCP) as a para-disubstituted benze...
Alexander I Taylor,Philipp Holliger
Alexander I Taylor
Robert C Spitale,John C Chaput
Robert C Spitale
Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser [0.03%]
设计一种含有光引发剂的蛋白质编码中间激发态被X射线自由电子激光捕获
Xiaohong Liu,Pengcheng Liu,Hongjie Li et al.
Xiaohong Liu et al.
One of the primary objectives in chemistry research is to observe atomic motions during reactions in real time. Although X-ray free-electron lasers (XFELs) have facilitated the capture of reaction intermediates using time-resolved serial fe...
Conformational and functional changes of the native neuropeptide somatostatin occur in the presence of copper and amyloid-β [0.03%]
铜和淀粉样蛋白-β存在时,天然神经肽生长抑素构象及功能发生改变
Jiyeon Han,Jiwon Yoon,Jeongcheol Shin et al.
Jiyeon Han et al.
The progression of neurodegenerative disorders can lead to impaired neurotransmission; however, the role of pathogenic factors associated with these diseases and their impact on the structures and functions of neurotransmitters have not bee...
M Rodrigues,P Bhattacharjee,A Brinkmalm et al.
M Rodrigues et al.
The composition of soluble toxic protein aggregates formed in vivo is currently unknown in neurodegenerative diseases, due to their ultra-low concentration in human biofluids and their high degree of heterogeneity. Here we report a method t...
Highly conducting single-molecule topological insulators based on mono- and di-radical cations [0.03%]
基于单线态和双线态分子阳离子的高度导电的单分子拓扑绝缘体
Liang Li,Jonathan Z Low,Jan Wilhelm et al.
Liang Li et al.
Single-molecule topological insulators are promising candidates as conducting wires over nanometre length scales. A key advantage is their ability to exhibit quasi-metallic transport, in contrast to conjugated molecular wires which typicall...