Photoinduced bulk polymerization strategy in melt state for recyclable polydiene derivatives [0.03%]
熔融态光诱导聚丁二烯衍生物的本体聚合策略用于制备可回收材料
Pengfei Wu,Qixuan Hu,Andrew V Marquardt et al.
Pengfei Wu et al.
Polydienes, particularly 1,3-butadiene derivatives, are integral to the chemical industry due to their widespread applications. However, current commercial production methods depend largely on gas- or solution-phase processes involving soph...
Mo Yang,Peri R Prestwood,Luiz F M Passalacqua et al.
Mo Yang et al.
RNA-based fluorogenic aptamers, such as Mango, are uniquely powerful tools for imaging RNA that activate the fluorescence of a weakly or non-fluorescent small molecule when bound. A central challenge has been to develop brighter, more speci...
Trinucleotide substrates under pH-freeze-thaw cycles enable open-ended exponential RNA replication by a polymerase ribozyme [0.03%]
pH冻结-融化循环下的三核苷酸底物使多聚酶核糖核酸酶实现无限指数RNA复制
James Attwater,Teresa L Augustin,Joseph F Curran et al.
James Attwater et al.
RNA replication is considered a key process in the origins of life. However, both enzymatic and non-enzymatic RNA replication cycles are impeded by the 'strand separation problem', a form of product inhibition arising from the extraordinary...
Mimicking the structure and function of tau folds associated with disease [0.03%]
模拟与疾病相关Tau折叠的结构和功能
Joost Schymkowitz,Frederic Rousseau
Joost Schymkowitz
Alessandro Fracassi,Andrés Seoane,Roberto J Brea et al.
Alessandro Fracassi et al.
The plasticity of living cell membranes relies on complex metabolic networks fueled by cellular energy. These metabolic processes exert direct control over membrane properties such as lipid composition and morphological plasticity, which ar...
Andrea Rosichini,Starla D Glover
Andrea Rosichini
Gut microbiota-mediated GPCR drug metabolism affects downstream pharmacological activity [0.03%]
肠道微生物介导的GPCR药物代谢影响下游药理作用
Amy K Bracken,Pamela V Chang
Amy K Bracken
Discovery of acylsulfenic acid-featuring natural product sulfenicin and characterization of its biosynthesis [0.03%]
硫芬酸类天然产物硫芬菌素的发现及其生物合成途径的研究
Dan Xue,Hongbin Zou,Yanping Qiu et al.
Dan Xue et al.
Life's organic molecules are built with diverse functional groups that enable various importance biological functions. As such, the discovery of unique functional groups in nature can expand our understanding of the natural world. Here we r...
A framework for evaluating the chemical knowledge and reasoning abilities of large language models against the expertise of chemists [0.03%]
评估大型语言模型的化学知识和推理能力是否达到化学家的专业水平的框架
Adrian Mirza,Nawaf Alampara,Sreekanth Kunchapu et al.
Adrian Mirza et al.
Large language models (LLMs) have gained widespread interest owing to their ability to process human language and perform tasks on which they have not been explicitly trained. However, we possess only a limited systematic understanding of t...
Structural insights into two thiamine diphosphate-dependent enzymes and their synthetic applications in carbon-carbon linkage reactions [0.03%]
有关两个焦磷酸硫胺素依赖酶的结构洞察及其在碳-碳连接反应中的合成应用
Tan Liu,Guiyang Wang,Jiahui Yu et al.
Tan Liu et al.
The α-hydroxy-β-keto acid synthases are thiamine diphosphate-dependent enzymes catalysing carbon-carbon linkage reactions in the biosynthesis of primary metabolites and various secondary metabolites. However, the substrate selectivity and...