Nick W Johnson,Marcos Valenzuela-Ortega,Thomas W Thorpe et al.
Nick W Johnson et al.
Nature has evolved an exquisite yet limited set of chemical reactions that underpin the function of all living organisms. By contrast, the field of synthetic organic chemistry can access reactivity not observed in nature, and integration of...
Wei Long Soon,Hui Qing Chong,Jee Loon Foo et al.
Wei Long Soon et al.
Myojeong Kim,Carys E Obertone,Christopher B Kelly et al.
Myojeong Kim et al.
Functional group interconversions are particularly sought after by medicinal chemists as a means to enable both lead optimization and library diversification. Here we report SO2 insertion into the C-N bond of primary amines, enabling the di...
Hongjie Jiang,Jing Zhao,Qingyu Meng et al.
Hongjie Jiang et al.
Metal-ligand multiple bonds are ubiquitous in coordination and organometallic chemistry. In contrast, lanthanide-carbon multiple bonds are difficult to form. The isolation of complexes containing lanthanide-carbon double bonds with terminal...
Yanyun Wu,Jiongjiang Liu,Mengya Wang et al.
Yanyun Wu et al.
The emergence of organic semiconductors has laid the foundation for the field of plastic electronics. Controlling π-conjugation by designing proper conjugated moieties is one of the commonest strategies for achieving desired semiconducting...
Function without form in synthetic polymers mimicking protein hydration [0.03%]
仿生水合蛋白质的合成聚合物功能化分子设计
Michael A Webb
Michael A Webb
On-DNA C-H functionalization of electron-rich arenes for DNA-encoded libraries [0.03%]
富电子芳烃的DNA编码库的DNA上C-H功能化
Eduardo de Pedro Beato,Luca Torkowski,Philipp Hartmann et al.
Eduardo de Pedro Beato et al.
DNA-encoded libraries (DELs) are useful for hit discovery in the pharmaceutical industry. Although a large number of individually coded molecules are accessible through DELs, their structural diversity is limited because few transformations...
Synthesis of diverse terpenoid frameworks via enzyme-enabled abiotic scaffold hop [0.03%]
基于酶的非生物骨架_hop合成多样化萜类框架化合物
Heping Deng,Junhong Yang,Fuzhuo Li et al.
Heping Deng et al.
Due to the structural complexity of natural products, their target-oriented syntheses usually require the design of individualized routes that are tailor-made for the specific targets. As such, route redesign is needed when targets of diffe...
Oxygen transposition of formamide to α-aminoketone moiety in a carbene-initiated domino reaction [0.03%]
卡宾引发的串联反应中甲酰胺的氧转位至α-氨基酮片段
Yan Luo,Guanglong Huang,Kuiling Ding et al.
Yan Luo et al.
The carbonyl group is one of the most important functional groups in organic chemistry. C=O cleavage and full transfer of the resulting fragments into final products would be extremely attractive and open up new avenues in retrosynthetic pl...