Gaurav Ashish Kamat,Michaela Burke Stevens
Gaurav Ashish Kamat
Sakari Lepikko,Ygor Morais Jaques,Muhammad Junaid et al.
Sakari Lepikko et al.
Friction determines whether liquid droplets slide off a solid surface or stick to it. Surface heterogeneity is generally acknowledged as the major cause of increased contact angle hysteresis and contact line friction of droplets. Here we ch...
Stereocontrolled access to thioisosteres of nucleoside di- and triphosphates [0.03%]
手性硫代核苷酸二磷酸和三磷酸的立体专一合成
Hai-Jun Zhang,Michał Ociepa,Molhm Nassir et al.
Hai-Jun Zhang et al.
Nucleoside diphosphates and triphosphates impact nearly every aspect of biochemistry; however, the use of such compounds as tools or medicinal leads for nucleotide-dependent enzymes and receptors is hampered by their rapid in vivo metabolis...
Zi-Xuan Wang,Keith Livingstone,Carla Hümpel et al.
Zi-Xuan Wang et al.
Fluorinated small molecules are prevalent across the functional small-molecule spectrum, but the scarcity of naturally occurring sources creates an opportunity for creative endeavour in developing routes to access these important materials....
Aromatic pentaamide macrocycles bind anions with high affinity for transport across biomembranes [0.03%]
芳香族五酰胺大环通过生物膜结合阴离子运输
Ruikai Cao,Robert B Rossdeutcher,Yulong Zhong et al.
Ruikai Cao et al.
The convergent positioning of functional groups in biomacromolecules leads to good binding, catalytic and transport capabilities. Synthetic frameworks capable of convergently locking functional groups with minimized conformational uncertain...
Tetrafluorenofulvalene as a sterically frustrated open-shell alkene [0.03%]
受空间位阻限制的开壳烯烃——四氟代烯基联苯自由基的例子
Bibek Prajapati,Madan D Ambhore,Duy-Khoi Dang et al.
Bibek Prajapati et al.
Electronic and steric effects are known to greatly influence the structure, characteristics and reactivity of organic compounds. A typical π bond is weakened by oxidation (corresponding to the removal of electrons from bonding orbitals), b...
Modular synthesis of 1,2-azaborines via ring-opening BN-isostere benzannulation [0.03%]
基于开环BN等电子体苯并化的1,2-偶氮硼烯模块化合成
Hairong Lyu,Thomas H Tugwell,Zhijie Chen et al.
Hairong Lyu et al.
1,2-Azaborines represent a unique class of benzene isosteres that have attracted interest for developing pharmaceuticals with better potency and bioavailability. However, it remains a long-standing challenge to prepare monocyclic 1,2-azabor...
Thomas M Klapötke
Thomas M Klapötke