Accelerating the discovery of alkyl halide-derived natural products using halide depletion [0.03%]
利用卤素耗尽加速发现烷基卤代烃衍生的天然产物
Nathaniel R Glasser,Dongtao Cui,Douglas D Risser et al.
Nathaniel R Glasser et al.
Even in the genomic era, microbial natural product discovery workflows can be laborious and limited in their ability to target molecules with specific structural features. Here we leverage an understanding of biosynthesis to develop a workf...
D Dewran Kocak,Bryan L Roth
D Dewran Kocak
Li-Qing Ren,Chuan He
Li-Qing Ren
Elie Benchimol,Jacopo Tessarolo,Guido H Clever
Elie Benchimol
Stimuli-responsive behaviour is key to the design of smart materials, surfaces, nano-systems and effector molecules, allowing their application as switchable catalysts, molecular transporters, bioimaging probes or caged drugs. Supramolecula...
Ni-catalysed assembly of axially chiral alkenes from alkynyl tetracoordinate borons via 1,3-metallate shift [0.03%]
通过1,3-金属迁移由炔基四配位硼合成轴手性烯烃的镍催化组装过程
Xingxing Ma,Mengwei Tan,Luo Li et al.
Xingxing Ma et al.
Asymmetric synthesis based on a metallate shift of tetracoordinate borons is an intriguing and challenging topic. Despite the construction of central chirality from tetracoordinate boron species via a 1,2-metallate shift, catalytic asymmetr...
Ultrafast Raman observation of the perpendicular intermediate phantom state of stilbene photoisomerization [0.03%]
茋光异构化垂直中间虚态的超快拉曼观测
Hikaru Kuramochi,Takuro Tsutsumi,Kenichiro Saita et al.
Hikaru Kuramochi et al.
Trans-cis photoisomerization is generally described by a model in which the reaction proceeds via a common intermediate having a perpendicular conformation around the rotating bond, irrespective of from which isomer the reaction starts. Nev...
Metastable gallium hydride mediates propane dehydrogenation on H2 co-feeding [0.03%]
metastable GaH3介导的H2共供料上的丙烷脱氢反应
Guodong Sun,Zhi-Jian Zhao,Lulu Li et al.
Guodong Sun et al.
In heterogeneous catalysis, the catalytic dehydrogenation reactions of hydrocarbons often exhibit a negative pressure dependence on hydrogen due to the competitive chemisorption of hydrocarbons and hydrogen. However, some catalysts show a p...
Probing the chemical 'reactome' with high-throughput experimentation data [0.03%]
利用高通量实验数据探究化学“反应组”
Emma King-Smith,Simon Berritt,Louise Bernier et al.
Emma King-Smith et al.
High-throughput experimentation (HTE) has the potential to improve our understanding of organic chemistry by systematically interrogating reactivity across diverse chemical spaces. Notable bottlenecks include few publicly available large-sc...
Rumiana Dimova
Rumiana Dimova