Protein-templated ligand discovery via the selection of DNA-encoded dynamic libraries [0.03%]
通过选择DNA编码的动态库实现蛋白质模板配体发现
Yu Zhou,Wenyin Shen,Ying Gao et al.
Yu Zhou et al.
DNA-encoded chemical libraries (DELs) have become a powerful technology platform in drug discovery. Dual-pharmacophore DELs display two sets of small molecules at the termini of DNA duplexes, thereby enabling the identification of synergist...
Characterizing ATP processing by the AAA+ protein p97 at the atomic level [0.03%]
AAA+蛋白p97在原子水平上处理ATP的特性分析
Mikhail Shein,Manuel Hitzenberger,Tat Cheung Cheng et al.
Mikhail Shein et al.
The human enzyme p97 regulates various cellular pathways by unfolding hundreds of protein substrates in an ATP-dependent manner, making it an essential component of protein homeostasis and an impactful pharmacological target. The hexameric ...
Hyunchul Oh,Nikolay Tumanov,Voraksmy Ban et al.
Hyunchul Oh et al.
Nanoporous materials have attracted great attention for gas storage, but achieving high volumetric storage capacity remains a challenge. Here, by using neutron powder diffraction, volumetric gas adsorption, inelastic neutron scattering and ...
Thomas Kruse,Søren Østergaard
Thomas Kruse
Determinants that enable disordered protein assembly into discrete condensed phases [0.03%]
决定无序蛋白组装成离散浓密相的因素
Rachel M Welles,Kandarp A Sojitra,Mikael V Garabedian et al.
Rachel M Welles et al.
Cells harbour numerous mesoscale membraneless compartments that house specific biochemical processes and perform distinct cellular functions. These protein- and RNA-rich bodies are thought to form through multivalent interactions among prot...
Near-atomic-resolution structure of J-aggregated helical light-harvesting nanotubes [0.03%]
J聚集中螺旋光收集纳米管的近原子分辨率结构
Arundhati P Deshmukh,Weili Zheng,Chern Chuang et al.
Arundhati P Deshmukh et al.
Cryo-electron microscopy has delivered a resolution revolution for biological self-assemblies, yet only a handful of structures have been solved for synthetic supramolecular materials. Particularly for chromophore supramolecular aggregates,...
Ultrafast electronic relaxation pathways of the molecular photoswitch quadricyclane [0.03%]
分子光开关quadricyclane的超快电子松弛路径
Kurtis D Borne,Joseph C Cooper,Michael N R Ashfold et al.
Kurtis D Borne et al.
The light-induced ultrafast switching between molecular isomers norbornadiene and quadricyclane can reversibly store and release a substantial amount of chemical energy. Prior work observed signatures of ultrafast molecular dynamics in both...
Martin Keilwerth,Weiqing Mao,Moritz Malischewski et al.
Martin Keilwerth et al.
Complexes of iron in high oxidation states are captivating research subjects due to their pivotal role as active intermediates in numerous catalytic processes. Structural and spectroscopic studies of well-defined model complexes often provi...
Spilling the tea [0.03%]
泄露消息
Matthew R Hartings
Matthew R Hartings