Deciphering functional roles of protein succinylation and glutarylation using genetic code expansion [0.03%]
利用遗传密码扩展技术解析蛋白质琥珀酰化和戊二酰化功能作用
Maria Weyh,Marie-Lena Jokisch,Tuan-Anh Nguyen et al.
Maria Weyh et al.
Post-translational modifications (PTMs) dynamically regulate cellular processes. Lysine undergoes a range of acylations, including malonylation, succinylation (SucK) and glutarylation (GluK). These PTMs increase the size of the lysine side ...
Catalyst self-assembly accelerates bimetallic light-driven electrocatalytic H2 evolution in water [0.03%]
催化剂自组装加速水相双金属光驱动电催化产氢反应
Isaac N Cloward,Tianfei Liu,Jamie Rose et al.
Isaac N Cloward et al.
Hydrogen evolution is an important fuel-generating reaction that has been subject to mechanistic debate about the roles of monometallic and bimetallic pathways. The molecular iridium catalysts in this study undergo photoelectrochemical dihy...
Joshua D Sieber
Joshua D Sieber
Aidan K Haney,T Ashton Cropp
Aidan K Haney
Dynamic three-dimensional structures of a metal-organic framework captured with femtosecond serial crystallography [0.03%]
利用飞秒串行晶体学捕捉金属有机框架的动态三维结构
Jaedong Kang,Yunbeom Lee,Seonggon Lee et al.
Jaedong Kang et al.
Crystalline systems consisting of small-molecule building blocks have emerged as promising materials with diverse applications. It is of great importance to characterize not only their static structures but also the conversion of their stru...
Silicon-RosIndolizine fluorophores with shortwave infrared absorption and emission profiles enable in vivo fluorescence imaging [0.03%]
具有短波红外吸收和发射特性的硅-罗 índ啉化荧光团可实现体内荧光成像
William E Meador,Eric Y Lin,Irene Lim et al.
William E Meador et al.
In vivo fluorescence imaging in the shortwave infrared (SWIR, 1,000-1,700 nm) and extended SWIR (ESWIR, 1,700-2,700 nm) regions has tremendous potential for diagnostic imaging. Although image contrast has been shown to improve as longer wav...
Non-modular fatty acid synthases yield distinct N-terminal acylation in ribosomal peptides [0.03%]
非模块脂肪酸合成酶产生核糖体肽的N末端酰基化
Hengqian Ren,Chunshuai Huang,Yuwei Pan et al.
Hengqian Ren et al.
Recent efforts in genome mining of ribosomally synthesized and post-translationally modified peptides (RiPPs) have expanded the diversity of post-translational modification chemistries. However, RiPPs are rarely reported as hybrid molecules...
Enantioselective propargylic amination and related tandem sequences to α-tertiary ethynylamines and azacycles [0.03%]
高立体选择性炔丙胺化及相关的串联反应生成α-季碳乙炔胺和氮杂环化合物
Zheng Zhang,Ying Sun,Yi Gong et al.
Zheng Zhang et al.
Chiral α-tertiary amines and related azacycles are sought-after compounds for drug development. Despite progress in the catalytic asymmetric construction of aza-quaternary stereocentres, enantioselective synthesis of multifunctional α-ter...
Cui Wang,Han Li,Tobias H Bürgin et al.
Cui Wang et al.
Photoredox catalysis relies on light-induced electron transfer leading to a radical pair comprising an oxidized donor and a reduced acceptor in a solvent cage. For productive onward reaction to occur, the oxidized donor and the reduced acce...