Enabling nucleophilic reactivity in molecular calcium fluoride complexes [0.03%]
分子钙氟化物复合物中亲核反应活性的激活
Job J C Struijs,Mathias A Ellwanger,Agamemnon E Crumpton et al.
Job J C Struijs et al.
Calcium fluoride is the ultimate source of all fluorochemicals. Current synthetic approaches rely on the use of HF, generated from naturally occurring fluorspar and sulfuric acid. Methods for constructing E-F bonds directly from CaF2 have l...
Enantioselective construction of stereogenic-at-sulfur(IV) centres via catalytic acyl transfer sulfinylation [0.03%]
催化酰基转移磺化构建S手性中心
Tao Wei,Han-Le Wang,Yin Tian et al.
Tao Wei et al.
Chiral sulfur pharmacophores are crucial for drug discovery in bioscience and medicinal chemistry. While the catalytic asymmetric synthesis of sulfoxides and sulfinate esters with stereogenic-at-sulfur(IV) centres is well developed, the syn...
John F C Steele,Stephen Wallace
John F C Steele
Julie E Niklas,Kaitlyn S Otte,Chad M Studvick et al.
Julie E Niklas et al.
Neptunium is an actinide element sourced from anthropogenic production, and, unlike naturally abundant uranium, its coordination chemistry is not well developed in all accessible oxidation states. High-valent neptunium generally requires st...
Yanlong Jiang,Hans Renata
Yanlong Jiang
Fusicoccane diterpenoids display intriguing biological activities, including the ability to act as modulators of 14-3-3 protein-protein interactions. However, their innate structural complexity and diverse oxygenation patterns present enorm...
Florian Auras,Laura Ascherl,Volodymyr Bon et al.
Florian Auras et al.
Porous covalent organic frameworks (COFs) enable the realization of functional materials with molecular precision. Past research has typically focused on generating rigid frameworks where structural and optoelectronic properties are static....
Selection of a promiscuous minimalist cAMP phosphodiesterase from a library of de novo designed proteins [0.03%]
从头设计蛋白质文库中选择一种多配偶简朴型cAMP磷酸二酯酶
J David Schnettler,Michael S Wang,Maximilian Gantz et al.
J David Schnettler et al.
The ability of unevolved amino acid sequences to become biological catalysts was key to the emergence of life on Earth. However, billions of years of evolution separate complex modern enzymes from their simpler early ancestors. To probe how...
Persistent organonickel complexes as general platforms for Csp2-Csp3 coupling reactions [0.03%]
持久性有机镍配合物作为C(sp2)-C(sp3)偶联反应的通用平台
Long P Dinh,Hunter F Starbuck,Taylor B Hamby et al.
Long P Dinh et al.
The importance of constructing Csp2-Csp3 bonds has motivated the development of electrochemical, photochemical and thermal activation methods to reductively couple abundant aryl and alkyl electrophiles. However, these methodologies are limi...
Formylation boosts the performance of light-driven overcrowded alkene-derived rotary molecular motors [0.03%]
形式化物促进光驱动拥挤烯烃衍生的分子马达性能提高
Jinyu Sheng,Wojciech Danowski,Andy S Sardjan et al.
Jinyu Sheng et al.
Artificial molecular motors and machines constitute a critical element in the transition from individual molecular motion to the creation of collective dynamic molecular systems and responsive materials. The design of artificial light-drive...