Accessing elusive σ-type cyclopropenium cation equivalents through redox gold catalysis [0.03%]
基于金催化的氧化还原反应获得难捉摸的σ型环丙烯𬭩正离子等价物
Xiangdong Li,Matthew D Wodrich,Jérôme Waser
Xiangdong Li
Cyclopropenes are the smallest unsaturated carbocycles. Removing one substituent from cyclopropenes leads to cyclopropenium cations (C3+ systems, CPCs). Stable aromatic π-type CPCs were discovered by Breslow in 1957 by removing a substitue...
Sayad Doobary,Berit Olofsson
Sayad Doobary
Yu Wang,Cheng Bi,Yu Kawamata et al.
Yu Wang et al.
Electrophilic halogenation is a widely used tool employed by medicinal chemists to either pre-functionalize molecules for further diversity or incorporate a halogen atom into drugs or drug-like compounds to solve metabolic problems or modul...
Josef T Boronski,Agamemnon E Crumpton,Aisling F Roper et al.
Josef T Boronski et al.
Owing to its high toxicity, the chemistry of element number four, beryllium, is poorly understood. However, as the lightest elements provide the basis for fundamental models of chemical bonding, there is a need for greater insight into the ...
Michael Phillips,Kingshuk Ghosh
Michael Phillips
Liquid droplets form in cells to concentrate specific biomolecules (while excluding others) in order to perform specific functions. The molecular mechanisms that determine whether different macromolecules undergo co-partitioning or exclusio...
Ravi Yadav,Avijit Maiti,Marcel Schorpp et al.
Ravi Yadav et al.
Aromaticity in organic molecules is well defined, but its role in metal-only rings remains controversial. Here we introduce a supramolecular stabilization approach of a cationic {Bi4} rhomboid within the symmetric charge sphere of two bowl-...
Toby Journeaux,Gonçalo J L Bernardes
Toby Journeaux
Many systemic cancer chemotherapies comprise a combination of drugs, yet all clinically used antibody-drug conjugates (ADCs) contain a single-drug payload. These combination regimens improve treatment outcomes by producing synergistic antic...
Machine learning designs new GCGR/GLP-1R dual agonists with enhanced biological potency [0.03%]
基于增强生物活性的GIPRC/GLP-1R双激动剂的新药设计与机器学习研究
Anna M Puszkarska,Bruck Taddese,Jefferson Revell et al.
Anna M Puszkarska et al.
Several peptide dual agonists of the human glucagon receptor (GCGR) and the glucagon-like peptide-1 receptor (GLP-1R) are in development for the treatment of type 2 diabetes, obesity and their associated complications. Candidates must have ...
Inga-Alexandra Bischoff,Sergi Danés,Philipp Thoni et al.
Inga-Alexandra Bischoff et al.
Homobimetallic dimetallocenes exhibiting two identical metal atoms sandwiched between two η5 bonded cyclopentadienyl rings is a narrow class of compounds, with representative examples being dizincocene and diberyllocene. Here we report the...
Structural basis of the Meinwald rearrangement catalysed by styrene oxide isomerase [0.03%]
苯乙烯氧化异构酶催化Meinwald重排的结构基础
Basavraj Khanppnavar,Joel P S Choo,Peter-Leon Hagedoorn et al.
Basavraj Khanppnavar et al.
Membrane-bound styrene oxide isomerase (SOI) catalyses the Meinwald rearrangement-a Lewis-acid-catalysed isomerization of an epoxide to a carbonyl compound-and has been used in single and cascade reactions. However, the structural informati...