Josh Abbenseth
Josh Abbenseth
Rahul Dev Mukhopadhyay
Rahul Dev Mukhopadhyay
Collisional alignment and molecular rotation control the chemi-ionization of individual conformers of hydroquinone with metastable neon [0.03%]
次稳态氖与羟基苯醌个别构象分子的化学电离受碰撞方位和分子旋转控制
L Ploenes,P Straňák,A Mishra et al.
L Ploenes et al.
The relationship between the shape of a molecule and its chemical reactivity is a central tenet in chemistry. However, the influence of the molecular geometry on reactivity can be subtle and result from several opposing effects. Here, using...
An evolved artificial radical cyclase enables the construction of bicyclic terpenoid scaffolds via an H-atom transfer pathway [0.03%]
一种进化的人工环化酶可以通过氢原子转移途径构建双环萜类支架
Dongping Chen,Xiang Zhang,Anastassia Andreevna Vorobieva et al.
Dongping Chen et al.
While natural terpenoid cyclases generate complex terpenoid structures via cationic mechanisms, alternative radical cyclization pathways are underexplored. The metal-catalysed H-atom transfer reaction (M-HAT) offers an attractive means for ...
Protein semisynthesis reveals plasticity in HECT E3 ubiquitin ligase mechanisms [0.03%]
蛋白质半合成揭示HECT型E3泛素连接酶机制的可塑性
Hanjie Jiang,Bryant D Miller,Thibault Viennet et al.
Hanjie Jiang et al.
Lys ubiquitination is catalysed by E3 ubiquitin ligases and is central to the regulation of protein stability and cell signalling in normal and disease states. There are gaps in our understanding of E3 mechanisms, and here we use protein se...
Single crystals of purely organic free-standing two-dimensional woven polymer networks [0.03%]
纯有机二维织物聚合物网络的单晶
Ding Xiao,Zhitong Jin,Guan Sheng et al.
Ding Xiao et al.
The aesthetic and practicality of macroscopic fabrics continue to encourage chemists to weave molecules into interlaced patterns with the aim of providing emergent physical and chemical properties when compared with their starting materials...
Template-based copying in chemically fuelled dynamic combinatorial libraries [0.03%]
基于模板的化学燃料动态组合库中的复制机制研究
Christine M E Kriebisch,Ludwig Burger,Oleksii Zozulia et al.
Christine M E Kriebisch et al.
One of science's greatest challenges is determining how life can spontaneously emerge from a mixture of molecules. A complicating factor is that life and its molecules are inherently unstable-RNA and proteins are prone to hydrolysis and den...
Molecular-docking electrolytes enable high-voltage lithium battery chemistries [0.03%]
分子对接电解液能使高压锂电池化学体系成为可能
Baochen Ma,Haikuo Zhang,Ruhong Li et al.
Baochen Ma et al.
Ideal rechargeable lithium battery electrolytes should promote the Faradaic reaction near the electrode surface while mitigating undesired side reactions. Yet, conventional electrolytes usually show sluggish kinetics and severe degradation ...
Engineering a nanoscale liposome-in-liposome for in situ biochemical synthesis and multi-stage release [0.03%]
工程化纳米尺度脂质体中的脂质体用于原位生化合成及多级释放
Colin P Pilkington,Ignacio Gispert,Suet Y Chui et al.
Colin P Pilkington et al.
Soft-matter nanoscale assemblies such as liposomes and lipid nanoparticles have the potential to deliver and release multiple cargos in an externally stimulated and site-specific manner. Such assemblies are currently structurally simplistic...
Chenyang Hu,Nicolas H Rees,Maren Pink et al.
Chenyang Hu et al.
Nitroso compounds, R-N=O, are common intermediates in organic synthesis, and are typically amenable to storage and manipulation at ambient temperature under aerobic conditions. By contrast, phosphorus-containing analogues, such as R-P=O (R ...