Questioning claims of monitoring the Michael addition reaction at the single-molecule level [0.03%]
质疑迈克尔加成反应单分子水平监测的报道
Latha Venkataraman,Jan van Ruitenbeek
Latha Venkataraman
Reply to: Questioning claims of monitoring the Michael addition reaction at the single-molecule level [0.03%]
关于质疑迈克尔加成反应单分子水平监测的答复
Chen Yang,Kendall N Houk,Yonatan Dubi et al.
Chen Yang et al.
Modular enantioselective assembly of multi-substituted boron-stereogenic BODIPYs [0.03%]
模块化构建多取代手性硼原子立体生成的BODIPY化合物
Li-Qing Ren,Baoquan Zhan,Jiayi Zhao et al.
Li-Qing Ren et al.
Boron dipyrromethenes (BODIPYs) are some of the most popular and indispensable tetracoordinate boron compounds and have found widespread applications owing to their excellent spectroscopic and photophysical properties. BODIPYs possessing bo...
Fused radical SAM and αKG-HExxH domain proteins contain a distinct structural fold and catalyse cyclophane formation and β-hydroxylation [0.03%]
融合的SAM和αKG-HExxH结构域蛋白含有一个独特的结构褶皱并催化环糊精形成及β-羟基化反应
Yohei Morishita,Suze Ma,Eugenio De La Mora et al.
Yohei Morishita et al.
Two of nature's recurring binding motifs in metalloproteins are the CxxxCxxC motif in radical SAM enzymes and the 2-His-1-carboxylate motif found both in zincins and α-ketoglutarate and non-haem iron enzymes. Here we show the confluence of...
A single diiron enzyme catalyses the oxidative rearrangement of tryptophan to indole nitrile [0.03%]
一种单中心二铁酶催化色氨酸氧化重排生成吲哚腈
Sanjoy Adak,Naike Ye,Logan A Calderone et al.
Sanjoy Adak et al.
Nitriles are uncommon in nature and are typically constructed from oximes through the oxidative decarboxylation of amino acid substrates or from the derivatization of carboxylic acids. Here we report a third nitrile biosynthesis strategy fe...
Sheng Xu,Yuanyuan Ping,Minghao Xu et al.
Sheng Xu et al.
Carbohydrates play important roles in medicinal chemistry and biochemistry. However, their synthesis relies on specially designed glycosyl donors, which are often unstable and require multi-step synthesis. Furthermore, the catalytic and ste...
Small-molecule properties define partitioning into biomolecular condensates [0.03%]
小分子的性质决定了其进入生物分子凝聚体的状态
Sabareesan Ambadi Thody,Hanna D Clements,Hamid Baniasadi et al.
Sabareesan Ambadi Thody et al.
Biomolecular condensates regulate cellular function by compartmentalizing molecules without a surrounding membrane. Condensate function arises from the specific exclusion or enrichment of molecules. Thus, understanding condensate compositio...
Isolation of a NHC-stabilized heavier nitrile and its conversion into an isonitrile analogue [0.03%]
一种稳定的较重氰化物的氮杂环卡宾及其异氰类类似物的分离隔离
Martin E Doleschal,Arseni Kostenko,Jin Yu Liu et al.
Martin E Doleschal et al.
Nitriles (R-C≡N) have been investigated since the late eighteenth century and are ubiquitous encounters in organic and inorganic syntheses. In contrast, heavier nitriles, which contain the heavier analogues of carbon and nitrogen, are spar...