Jacob Aunstrup Larsen,Abigail Barclay,Nicola Vettore et al.
Jacob Aunstrup Larsen et al.
Amyloid fibrils are highly stable misfolded protein assemblies that play an important role in several neurodegenerative and systemic diseases. Although structural information of the amyloid state is now abundant, mechanistic details about t...
Engineering a DNA polymerase for modifying large RNA at specific positions [0.03%]
工程改造DNA聚合酶在特定位置修饰大RNA
Dian Chen,Zhanghui Han,Xiaoge Liang et al.
Dian Chen et al.
The synthesis of large RNA with precise modifications at specific positions is in high demand for both basic research and therapeutic applications, but efficient methods are limited. Engineered DNA polymerases have recently emerged as attra...
Defining proteoform-specific interactions for drug targeting in a native cell signalling environment [0.03%]
在天然细胞信号传导环境中定义针对药物靶向的蛋白组特异性相互作用
Corinne A Lutomski,Jack L Bennett,Tarick J El-Baba et al.
Corinne A Lutomski et al.
Understanding the dynamics of membrane protein-ligand interactions within a native lipid bilayer is a major goal for drug discovery. Typically, cell-based assays are used, however, they are often blind to the effects of protein modification...
Coacervate vesicles assembled by liquid-liquid phase separation improve delivery of biopharmaceuticals [0.03%]
通过液-液相分离聚集的聚合物囊泡能提高生物药物的递送效果
Ping Wen,Hanwei Huang,Ruizhe Zhang et al.
Ping Wen et al.
Vesicles play critical roles in cellular materials storage and signal transportation, even in the formation of organelles and cells. Natural vesicles are composed of a lipid layer that forms a membrane for the enclosure of substances inside...
Synthesis of three-dimensional covalent organic frameworks through a symmetry reduction strategy [0.03%]
通过降低对称性策略合成三维共价有机框架材料
Jianhong Chang,Zeyue Zhang,Haorui Zheng et al.
Jianhong Chang et al.
Three-dimensional (3D) covalent organic frameworks (COFs) hold significant promise for a variety of applications. However, conventional design approaches using regular building blocks limit the structural diversity of 3D COFs. Here we desig...
A pseudo-cubic metal-organic cage with conformationally switchable faces for dynamically adaptive guest encapsulation [0.03%]
具有动态适应主客体包封的构象可转换面的伪立方金属有机笼
Houyang Xu,Tanya K Ronson,Andrew W Heard et al.
Houyang Xu et al.
The creation of hosts capable of accommodating different guest molecules may enable these hosts to play useful roles in chemical purifications, among other applications. Metal-organic cages are excellent hosts for various guests, but they g...
Self-assembly of chiroptical ionic co-crystals from silver nanoclusters and organic macrocycles [0.03%]
由银纳米团簇和有机大环自组装形成的具有对映体光学活性的离子共晶晶体
Yingwei Li,Grant J Stec,Hong Ki Kim et al.
Yingwei Li et al.
Atomically precise nanoclusters can be assembled into ordered superlattices with unique electronic, magnetic, optical and catalytic properties. The co-crystallization of nanoclusters with functional organic molecules provides opportunities ...
Paulina Krzyszowska,Ewa Pacholska-Dudziak
Paulina Krzyszowska
Gregory R Alvey,David L Avetian,Markus D Kärkäs
Gregory R Alvey