Synthetic biomolecular condensates enhance translation from a target mRNA in living cells [0.03%]
合成生物分子凝聚物可增强活细胞中的目标信使核糖核酸翻译
Daniel Mark Shapiro,Sonal Deshpande,Seyed Ali Eghtesadi et al.
Daniel Mark Shapiro et al.
Biomolecular condensates composed of proteins and RNA are one approach by which cells regulate post-transcriptional gene expression. Their formation typically involves the phase separation of intrinsically disordered proteins with a target ...
Molecular contacts with an orthogonal π-skeleton induce amorphization to enhance perovskite solar cell performance [0.03%]
分子接触正交π骨架使无定形化增强钙钛矿太阳能电池性能
Jingjing Zhou,Yixin Luo,Runda Li et al.
Jingjing Zhou et al.
Perovskite solar cells represent a promising class of photovoltaics that have achieved exceptional levels of performance within a short time. Such high efficiencies often depend on the use of molecule-based selective contacts that form high...
Isotopic labelling of water reveals the hydrogen transfer route in electrochemical CO2 reduction [0.03%]
用水的同位素标记揭示电化学二氧化碳还原中的氢转移路径
Jiguang Zhang,Chengyi Zhang,Meng Wang et al.
Jiguang Zhang et al.
Understanding the hydrogenation pathway in electrochemical CO2 reduction is important for controlling product selectivity. The Eley-Rideal mechanism involving proton-coupled electron transfer directly from solvent water is often considered ...
Rishab N Iyer,David Favela,Andras Domokos et al.
Rishab N Iyer et al.
Anecdotal reports and preliminary clinical trials suggest that the psychoactive alkaloid ibogaine and its active metabolite noribogaine have powerful anti-addictive properties, producing long-lasting therapeutic effects across a range of su...
Niki Mavragani,Muralee Murugesu
Niki Mavragani
Bruce C Gibb
Bruce C Gibb
Protons undermine lithium-ion batteries with positively disastrous results [0.03%]
有害的 proton 令锂离子电池“同归于尽”
Noah P Holzapfel,Veronica Augustyn
Noah P Holzapfel
Enantioselective synthesis of 2-substituted bicyclo[1.1.1]pentanes via sequential asymmetric imine addition of bicyclo[1.1.0]butanes and skeletal editing [0.03%]
轴手性2-取代双环[1.1.1]戊烷的连续不对称亚胺加成及构架编辑合成研究
Jin-Teng Che,Wei-Yi Ding,Hong-Bo Zhang et al.
Jin-Teng Che et al.
The substitution of an aromatic ring with a C(sp3)-rich bicyclic hydrocarbon, known as bioisosteric replacement, plays a crucial role in modern drug discovery. Substituted bicyclo[1.1.1]pentanes (BCPs) are particularly noteworthy owing to t...
Ivan V Khariushin,Philipp Thielert,Elisa Zöllner et al.
Ivan V Khariushin et al.
Molecular spin qubits have the advantages of synthetic flexibility and amenability to be tailored to specific applications. Among them, chromophore-radical systems have emerged as appealing qubit candidates. These systems can be initiated b...
Computational design of highly signalling-active membrane receptors through solvent-mediated allosteric networks [0.03%]
通过溶剂介导的别构网络计算设计高信号活性膜受体
K-Y M Chen,J K Lai,L S P Rudden et al.
K-Y M Chen et al.
Protein catalysis and allostery require the atomic-level orchestration and motion of residues and ligand, solvent and protein effector molecules. However, the ability to design protein activity through precise protein-solvent cooperative in...