Site-specific activation of the proton pump inhibitor rabeprazole by tetrathiolate zinc centres [0.03%]
四硫醇锌中心对质子泵抑制剂雷贝拉唑的定点活化
Teresa Marker,Raphael R Steimbach,Cecilia Perez-Borrajero et al.
Teresa Marker et al.
Proton pump inhibitors have become top-selling drugs worldwide. Serendipitously discovered as prodrugs that are activated by protonation in acidic environments, proton pump inhibitors inhibit stomach acid secretion by covalently modifying t...
Amphoteric chalcogen-bonding and halogen-bonding rotaxanes for anion or cation recognition [0.03%]
用于阴离子或阳离子识别的两性杂原子键合索烃和卤素键合索烃
Yuen Cheong Tse,Andrew Docker,Igor Marques et al.
Yuen Cheong Tse et al.
The ever-increasing demand in the development of host molecules for the recognition of charged species is stimulated by their fundamental roles in numerous biological and environmental processes. Here, capitalizing on the inherent amphoteri...
Gaolei Zhan,Brecht Koek,Yijia Yuan et al.
Gaolei Zhan et al.
The on-surface synthesis of two-dimensional (2D) polymers from monomers represents a useful strategy for designing lattice, orbital and spin symmetries. Like other 2D materials, the ordered stacking of 2D polymers into bilayers may allow de...
Catalytic difluorocarbene insertion enables access to fluorinated oxetane isosteres [0.03%]
催化二氟亚甲基插入可获得含氟氧杂环丁烷类似物
Tong-De Tan,Fang Zhou,Kevin P Quirion et al.
Tong-De Tan et al.
Skeletal editing of heterocyclic building blocks offers an appealing way to expand the accessible chemical space by diversifying molecular scaffolds for drug discovery. Despite the recent boom in this area, catalytic strategies that directl...
Johannes Maurer,Lukas Klerner,Jonathan Mai et al.
Johannes Maurer et al.
Cyclic crown ethers bind metal cations to form host-guest complexes. Lesser-known inverse crowns are rings of metal cations that encapsulate anionic entities, enabling multiple deprotonation reactions, often with unusual selectivity. Self-a...
Anion vacancies activate N2 to ammonia on Ba-Si orthosilicate oxynitride-hydride [0.03%]
钡-硅正硅酸氧氮氢材料中的阴离子空位激活N2合成氨反应
Zhujun Zhang,Kazuki Miyashita,Tong Wu et al.
Zhujun Zhang et al.
Anion vacancies on metal oxide surfaces have been studied as either active sites or promoting sites in various chemical reactions involving oxidation/reduction processes. However, oxide materials rarely work effectively as catalysts in the ...
Author Correction: Engineering a DNA polymerase for modifying large RNA at specific positions [0.03%]
作者更正：修饰特定位置大型RNA的DNA聚合酶的工程化
Dian Chen,Zhanghui Han,Xiaoge Liang et al.
Dian Chen et al.
Published Erratum
Nature chemistry. 2025 Feb 16. DOI:10.1038/s41557-025-01752-9 2025
Interface flexibility controls the nucleation and growth of supramolecular networks [0.03%]
界面柔韧性控制超分子网络的成核与生长
Vincenzo Caroprese,Cem Tekin,Veronika Cencen et al.
Vincenzo Caroprese et al.
Supramolecular networks are abundantly present in nature and, like crystalline materials, often develop from an initial nucleation site, followed by growth based on directional interactions between components. Traditionally, the binding str...
Surface-localized phase mediation accelerates quasi-solid-state reaction kinetics in sulfur batteries [0.03%]
表面局部相介导加速硫电池中的准固态反应动力学
Yatao Liu,Yun An,Chi Fang et al.
Yatao Liu et al.
Lithium-sulfur batteries promise high energy density storage but show poor stabilities owing to uncontrolled polysulfide dissolution. Although limiting polysulfide solvation to establish quasi-solid-state sulfur reaction can decouple electr...
Evolution of complex chemical mixtures reveals combinatorial compression and population synchronicity [0.03%]
复杂化学混合物的进化揭示了组合压缩和种群同步性
Kavita Matange,Vahab Rajaei,Pau Capera-Aragones et al.
Kavita Matange et al.
Many open questions about the origins of life are centred on the generation of complex chemical species. Past work has characterized specific chemical reactions that might lead to biological molecules. Here we establish an experimental mode...