Aryl halide cross-coupling via formate-mediated transfer hydrogenation [0.03%]
通过甲酸酯介导的转移氢化进行芳基卤化物交叉偶联反应
Yoon Cho,Yu-Hsiang Chang,Kevin P Quirion et al.
Yoon Cho et al.
Transfer hydrogenation is widely practised across all segments of chemical industry, yet its application to aryl halide reductive cross-coupling is undeveloped because of competing hydrogenolysis. Here, exploiting the distinct reactivity of...
Weitai Fan,Yuang Cui,Beibei Zhan et al.
Weitai Fan et al.
Synthetic organic chemists continually draw inspiration from biocatalytic processes to innovate synthetic methodologies beyond existing catalytic platforms. Within this context, although 1,2-amino migration represents a viable biochemical p...
Immanuel Plangger,Elias Schmidhammer,Sebastian Schaar et al.
Immanuel Plangger et al.
Methyltransferases are a broad class of enzymes that catalyse the transfer of methyl groups onto a wide variety of substrates and functionalities. In their most striking variant, bifunctional methyltransferase-cyclases both transfer a methy...
Discovery of a fluorinated macrobicyclic antibiotic through chemical synthesis [0.03%]
通过化学合成发现含氟大环双环类抗生素
Ben I C Tresco,Kelvin J Y Wu,Antonio Ramkissoon et al.
Ben I C Tresco et al.
The emergence of bacterial antimicrobial resistance threatens to undermine the utility of antibiotic therapy in medicine. This threat can be addressed, in part, by reinventing existing antibiotic classes using chemical synthesis. Here we pr...
The phosphate of life [0.03%]
生命的磷酸盐
Elena De Vita,Rebecca Page
Elena De Vita
Shira Joudan
Shira Joudan
Supramolecular coordination cages as crystalline sponges through a symmetry mismatch strategy [0.03%]
通过不对称失配策略使超分子配位笼成为晶体海绵
Wei He,Yikuan Yu,Kenta Iizuka et al.
Wei He et al.
The crystalline sponge method enables single-crystal X-ray diffraction analysis of guests absorbed within single-crystalline porous materials. However, its application with large or highly polar guests remains challenging. In this study, we...
Preparation, separation and storage of N-monofluoromethyl amides and carbamates [0.03%]
N-单氟甲基酰胺和碳酸酯的制备、分离及储存
Min Tao,Jiasheng Qian,Linbei Deng et al.
Min Tao et al.
N-monofluoromethyl (N-CH2F) amides, combining amide and monofluoromethyl motifs, represent a practical modification of the amide bond that can mimic N-CH3 amides. Despite the potential value in transforming peptides and peptidomimetics with...
Direct stereoselective C(sp3)-H alkylation of saturated heterocycles using olefins [0.03%]
使用烯烃直接对饱和杂环进行C（sp3）-H键的立体选择性烷基化
Zhijun Zhou,Yang Ke,Rui Miao et al.
Zhijun Zhou et al.
Despite cross-coupling strategies that enable the functionalization of aromatic heterocycles, the enantioselective C(sp3)-H alkylation of readily available saturated hydrocarbons to construct C(sp3)-C(sp3) bonds remains a formidable challen...