Aldostefano Porcari,Marianna Fontana,Julian D Gillmore
Aldostefano Porcari
Transthyretin cardiac amyloidosis (ATTR-CA) is an increasingly recognized cause of heart failure (HF) and mortality worldwide. Advances in non-invasive diagnosis, coupled with the development of effective treatments, have shifted ATTR-CA fr...
Cardiovascular effects of incretins: focus on glucagon-like peptide-1 receptor agonists [0.03%]
肠降血糖素对心血管系统的影响及胰高血糖素样肽-1受体激动剂的作用机制
Sten Madsbad,Jens J Holst
Sten Madsbad
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been used to treat patients with type 2 diabetes since 2005 and have become popular because of the efficacy and durability in relation to glycaemic control in combination with weigh...
Extracellular vesicles signal from bones to vessels: an answer to the 'calcification paradox'? [0.03%]
细胞外小泡信号传递：骨向血管的信号传递能解答“钙化悖论”问题吗？
Gemma Chiva-Blanch,Sean M Davidson
Gemma Chiva-Blanch
Tim Koopmans,Eva van Rooij
Tim Koopmans
Fasting triglycerides are positively associated with cardiovascular mortality risk in people with diabetes [0.03%]
糖尿病患者空腹甘油三酯与心血管死亡风险呈正相关
Yutang Wang,Yan Fang,Dianna J Magliano et al.
Yutang Wang et al.
Aims: We investigated the association of fasting triglycerides with cardiovascular disease (CVD) mortality. Methods and results: This c...
Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage [0.03%]
量化肠道微生物群对炎症和高血压器官损伤的影响
Ellen G Avery,Hendrik Bartolomaeus,Ariana Rauch et al.
Ellen G Avery et al.
Aims: Hypertension (HTN) can lead to heart and kidney damage. The gut microbiota has been linked to HTN, although it is difficult to estimate its significance due to the variety of other features known to influence HTN. I...
From novel discovery tools and biomarkers to precision medicine-basic cardiovascular science highlights of 2021/22 [0.03%]
从新发现工具和生物标志物到精准医学——2021/22年度基础心血管科学亮点
Paul C Evans,Sean M Davidson,Johann Wojta et al.
Paul C Evans et al.
Here, we review the highlights of cardiovascular basic science published in 2021 and early 2022 on behalf of the European Society of Cardiology Council for Basic Cardiovascular Science. We begin with non-coding RNAs which have emerged as ce...
Antihypertensive drugs and brain function: mechanisms underlying therapeutically beneficial and harmful neuropsychiatric effects [0.03%]
降压药与脑功能：治疗有益及有害神经精神效应的机制
Carla Carnovale,Cristiana Perrotta,Sara Baldelli et al.
Carla Carnovale et al.
A bidirectional relationship exists between hypertension and psychiatric disorders, including unipolar and bipolar depression, anxiety, post-traumatic stress disorder (PTSD), psychosis, schizophrenia, mania, and dementia/cognitive decline. ...
Molecular stratification of arrhythmogenic mechanisms in the Andersen Tawil syndrome [0.03%]
Andersen-Tawil综合征心律失常机制的分子分层研究
Ana Isabel Moreno-Manuel,Lilian K Gutiérrez,María Linarejos Vera-Pedrosa et al.
Ana Isabel Moreno-Manuel et al.
Andersen-Tawil syndrome (ATS) is a rare inheritable disease associated with loss-of-function mutations in KCNJ2, the gene coding the strong inward rectifier potassium channel Kir2.1, which forms an essential membrane protein controlling car...
Surface Lin28A expression consistent with cellular stress parallels indicators of senescence [0.03%]
表面Lin28A表达与细胞应激一致，类似于衰老指标
Kathleen Broughton,Carolina Esquer,Oscar Echeagaray et al.
Kathleen Broughton et al.
Aims: Declining cellular functional capacity resulting from stress or ageing is a primary contributor to impairment of myocardial performance. Molecular pathway regulation of biological processes in cardiac interstitial c...