SETD7 methyltransferase is a key druggable target for effective cardioprotection from myocardial ischaemic injury [0.03%]
组蛋白甲基转移酶SETD7是防治心肌缺血损伤的关键药物作用靶点
Daniele Torella,Nadia Salerno,Eleonora Cianflone
Daniele Torella
Blood pressure and risk of venous thromboembolism: a cohort analysis of 5.5 million UK adults and Mendelian randomization studies [0.03%]
基于50万英国成年人队列和孟德尔随机化研究分析血压与静脉血栓栓塞风险的关系
Milad Nazarzadeh,Zeinab Bidel,Hamid Mohseni et al.
Milad Nazarzadeh et al.
Aims: Evidence for the effect of elevated blood pressure (BP) on the risk of venous thromboembolism (VTE) has been conflicting. We sought to assess the association between systolic BP and the risk of VTE. ...
Meta-Analysis
Cardiovascular research. 2023 May 2;119(3):835-842. DOI:10.1093/cvr/cvac135 2023
Nicotine exacerbates endothelial dysfunction and drives atherosclerosis via extracellular vesicle-miRNA [0.03%]
尼古丁通过细胞外囊泡-微小RNA加剧内皮功能障碍和动脉粥样硬化病变
Chao Wang,Cong Liu,Jiaxin Shi et al.
Chao Wang et al.
Aims: Nicotine, a major component of tobacco, is an important factor contributing to atherosclerosis. However, the molecular mechanisms underlying the link between nicotine and atherosclerosis are unclear. As extracellula...
Emerging epigenetic therapies of cardiac fibrosis and remodelling in heart failure: from basic mechanisms to early clinical development [0.03%]
心脏纤维化和心力衰竭重塑的表观遗传学治疗：从基本机制到早期临床开发
Timothy A McKinsey,Roger Foo,Chukwuemeka George Anene-Nzelu et al.
Timothy A McKinsey et al.
Cardiovascular diseases and specifically heart failure (HF) impact global health and impose a significant economic burden on society. Despite current advances in standard of care, the risks for death and readmission of HF patients remain un...
Inflammatory pathways in heart failure with preserved left ventricular ejection fraction: implications for future interventions [0.03%]
射血分数保留的心力衰竭的炎症途径及其对未来干预的影响
Nicola Riccardo Pugliese,Pierpaolo Pellicori,Francesco Filidei et al.
Nicola Riccardo Pugliese et al.
Many patients with symptoms and signs of heart failure have a left ventricular ejection fraction ≥50%, termed heart failure with preserved ejection fraction (HFpEF). HFpEF is a heterogeneous syndrome mainly affecting older people who have ...
Natriuretic peptide pathways in heart failure: further therapeutic possibilities [0.03%]
心力衰竭中的利钠多肽通路：进一步的治疗可能
S Jeson Sangaralingham,Michaela Kuhn,Valentina Cannone et al.
S Jeson Sangaralingham et al.
The discovery of the heart as an endocrine organ resulted in a remarkable recognition of the natriuretic peptide system (NPS). Specifically, research has established the production of atrial natriuretic peptide (ANP) and B-type natriuretic ...
Mechanisms shared between cancer, heart failure, and targeted anti-cancer therapies [0.03%]
癌症、心力衰竭和抗癌靶向治疗之间的共通机制
Sanne de Wit,Claire Glen,Rudolf A de Boer et al.
Sanne de Wit et al.
Heart failure (HF) and cancer are the leading causes of death worldwide and accumulating evidence demonstrates that HF and cancer affect one another in a bidirectional way. Patients with HF are at increased risk for developing cancer, and H...
Multimodality imaging and transcriptomics to phenotype mitral valve dystrophy in a unique knock-in Filamin-A rat model [0.03%]
用于表型连接蛋白A敲入大鼠模型二尖瓣营养不良的多模式影像学和转录组学研究
Constance Delwarde,Claire Toquet,Pascal Aumond et al.
Constance Delwarde et al.
Aims: Degenerative mitral valve dystrophy (MVD) leading to mitral valve prolapse is the most frequent form of MV disease, and there is currently no pharmacological treatment available. The limited understanding of the pat...
FAVOR III China: quantitative flow ratio-guided coronary intervention in practice [0.03%]
中国 Favor Ⅲ 研究：定量血流分数指导冠脉介入的临床实践效果分析
Daniel Ang,Colin Berry
Daniel Ang
The pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single-cell resolution [0.03%]
单细胞分辨率下致命性COVID-19和特发性肺纤维化患者肺血管的差异性分析
Laura P M H de Rooij,Lisa M Becker,Laure-Anne Teuwen et al.
Laura P M H de Rooij et al.
Aims: Severe acute respiratory syndrome coronavirus-2 infection causes COVID-19, which in severe cases evokes life-threatening acute respiratory distress syndrome (ARDS). Transcriptome signatures and the functional releva...