Endothelial PTP4A1 mitigates vascular inflammation via USF1/A20 axis-mediated NF-κB inactivation [0.03%]
内皮PTP4A1通过USF1/A20轴介导的NF-κB失活减轻血管炎症
Min Ji Cho,Dong Gwang Lee,Jeong Woong Lee et al.
Min Ji Cho et al.
Aims: The nuclear factor-κB (NF-κB) signalling pathway plays a critical role in the pathogenesis of multiple vascular diseases. However, in endothelial cells (ECs), the molecular mechanisms responsible for the negative ...
Pathophysiology and pharmacology of G protein-coupled receptors in the heart [0.03%]
心脏G蛋白偶联受体的病理生理学和药理学
Alyssa Grogan,Emilio Y Lucero,Haoran Jiang et al.
Alyssa Grogan et al.
G protein-coupled receptors (GPCRs), comprising the largest superfamily of cell surface receptors, serve as fundamental modulators of cardiac health and disease owing to their key roles in the regulation of heart rate, contractile dynamics,...
GLUT-1/PKM2 loop dysregulation in patients with non-ST-segment elevation myocardial infarction promotes metainflammation [0.03%]
非ST段抬高型心肌梗死患者中GLUT-1/PKM2环路失调促进代谢炎症
Francesco Canonico,Daniela Pedicino,Anna Severino et al.
Francesco Canonico et al.
Aims: The functional capacity of the immune cells is strongly dependent on their metabolic state and inflammatory responses are characterized by a greater use of glucose in immune cells. This study is aimed to establish t...
Federico Capone,Cristian Sotomayor-Flores,David Bode et al.
Federico Capone et al.
Heart failure (HF) is marked by distinctive changes in myocardial uptake and utilization of energy substrates. Among the different types of HF, HF with preserved ejection fraction (HFpEF) is a highly prevalent, complex, and heterogeneous co...
Co-inhibition of immunoproteasome subunits LMP2 and LMP7 enables prevention of transplant arteriosclerosis [0.03%]
免疫蛋白酶体亚基LMP2和LMP7的共抑制可防止移植动脉硬化发生
Jun Li,Shaobo Hu,Henry W B Johnson et al.
Jun Li et al.
Aims: The loss of vascular wall cells in allotransplanted arteries is the initial event leading to transplant arteriosclerosis (TA) and ensuing loss of allograft function. Pharmacological agents able to prevent TA are cur...
Bruno Reichart,David K C Cooper,Matthias Längin et al.
Bruno Reichart et al.
For many patients with terminal/advanced cardiac failure, heart transplantation is the most effective, durable treatment option, and offers the best prospects for a high quality of life. The number of potentially life-saving donated human o...
Phenomapping in heart failure with preserved ejection fraction: insights, limitations, and future directions [0.03%]
射血分数保留的心力衰竭的表型绘图：认识、局限性和未来方向
Anthony E Peters,Jasper Tromp,Sanjiv J Shah et al.
Anthony E Peters et al.
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous entity with complex pathophysiology and manifestations. Phenomapping is the process of applying statistical learning techniques to patient data to identify distinct s...
New therapies for obesity [0.03%]
肥胖症的新疗法
Dimitris Papamargaritis,Carel W le Roux,Jens J Holst et al.
Dimitris Papamargaritis et al.
Obesity is a chronic disease associated with serious complications and increased mortality. Weight loss (WL) through lifestyle changes results in modest WL long-term possibly due to compensatory biological adaptations (increased appetite an...
The RAGE/DIAPH1 axis: mediator of obesity and proposed biomarker of human cardiometabolic disease [0.03%]
RAGE/DIAPH1轴：肥胖的介质和人类心脏代谢疾病的生物标志物提案
Lakshmi Arivazhagan,Collin J Popp,Henry H Ruiz et al.
Lakshmi Arivazhagan et al.
Overweight and obesity are leading causes of cardiometabolic dysfunction. Despite extensive investigation, the mechanisms mediating the increase in these conditions are yet to be fully understood. Beyond the endogenous formation of advanced...