Thomas Thum,Carolyn S P Lam
Thomas Thum
Wall shear stress-related plaque growth of lipid-rich plaques in human coronary arteries: an near-infrared spectroscopy and optical coherence tomography study [0.03%]
人类冠状动脉富含脂质斑块的与剪切应力相关的斑块生长：一项近红外光谱和光学相干断层成像研究
Eline M J Hartman,Giuseppe De Nisco,Annette M Kok et al.
Eline M J Hartman et al.
Aims: Low wall shear stress (WSS) is acknowledged to play a role in plaque development through its influence on local endothelial function. Also, lipid-rich plaques (LRPs) are associated with endothelial dysfunction. Howe...
Cholesterol accumulation in macrophages drives NETosis in atherosclerotic plaques via IL-1β secretion [0.03%]
胆固醇在巨噬细胞中的堆积通过分泌白介素-1β驱动动脉粥样硬化斑块中的NETosis过程
Mustafa Yalcinkaya,Panagiotis Fotakis,Wenli Liu et al.
Mustafa Yalcinkaya et al.
Aims: Neutrophil extracellular trap formation (NETosis) increases atherosclerotic plaque vulnerability and athero-thrombosis. However, mechanisms promoting NETosis during atherogenesis are poorly understood. We have shown...
Lower levels of small HDL particles associated with increased infectious disease morbidity and mortality: a population-based cohort study of 30 195 individuals [0.03%]
较小的高密度脂蛋白颗粒水平与感染性疾病发病率和死亡率升高相关：包含30195名个体的群体队列研究
Mads Harsløf,Kasper M Pedersen,Shoaib Afzal et al.
Mads Harsløf et al.
Aims: Low levels of HDL cholesterol have been associated with increased risk of infectious disease morbidity and mortality. Nuclear magnetic resonance (NMR) spectroscopy permits the measurement of HDL particle count and a...
Partial endothelial-to-mesenchymal transition mediated by HIF-induced CD45 in neointima formation upon carotid artery ligation [0.03%]
部分由HIF诱导的CD45介导的内皮-间充质转化参与颈动脉结扎后的新生内膜形成
Yoshito Yamashiro,Karina Ramirez,Kazuaki Nagayama et al.
Yoshito Yamashiro et al.
Aims: Endothelial-to-mesenchymal transition (EndMT) is a fundamental process in vascular remodelling. However, the precise regulatory mechanism of vascular remodelling during neointima formation and the source of neointim...
Antonin Trimaille,Sandy Hmadeh,Kensuke Matsushita et al.
Antonin Trimaille et al.
Aortic stenosis (AS) affects more than 10% of the population over 80 years of age and constitutes a major risk factor for heart failure, thromboembolic stroke, and death. A better understanding of the disease, including its interaction with...
A transposable element into the human long noncoding RNA CARMEN is a switch for cardiac precursor cell specification [0.03%]
人类长非编码RNA CARMEN中的可移动元件是心脏前体细胞分化的开关
Isabelle Plaisance,Panagiotis Chouvardas,Yuliangzi Sun et al.
Isabelle Plaisance et al.
Aims: The major cardiac cell types composing the adult heart arise from common multipotent precursor cells. Cardiac lineage decisions are guided by extrinsic and cell-autonomous factors, including recently discovered long...
Mechanisms of current therapeutic strategies for heart failure: more questions than answers? [0.03%]
心力衰竭当前治疗策略的机制：更多的问题还是答案？
Muhammad Shahzeb Khan,Izza Shahid,Stephen J Greene et al.
Muhammad Shahzeb Khan et al.
Heart failure (HF) is a complex, multifactorial and heterogeneous syndrome with substantial mortality and morbidity. Over the last few decades, numerous attempts have been made to develop targeted therapies that may attenuate the known path...
Low leukocyte mitochondrial DNA abundance drives atherosclerotic cardiovascular diseases: a cohort and Mendelian randomization study [0.03%]
低的白细胞线粒体DNA丰度促进动脉粥样硬化性心血管疾病：一项队列和孟德尔随机化研究
Jiao Luo,Raymond Noordam,J Wouter Jukema et al.
Jiao Luo et al.
Aim: Mitochondrial DNA dysfunction has been implicated in the pathogenesis of cardiovascular diseases. We aimed to investigate the associations between leukocyte mitochondrial DNA (mtDNA) abundance, as a proxy of mitochon...
Interferon-γ drives macrophage reprogramming, cerebrovascular remodelling, and cognitive dysfunction in a zebrafish and a mouse model of ion imbalance and pressure overload [0.03%]
干扰素-γ驱动巨噬重编程，脑血管重构以及在离子失衡和压力超负荷的斑马鱼和小鼠模型中的认知障碍
Dilem C Apaydin,Bhakti I Zakarauskas-Seth,Lorenzo Carnevale et al.
Dilem C Apaydin et al.
Aims: Dysregulated immune response contributes to inefficiency of treatment strategies to control hypertension and reduce the risk of end-organ damage. Uncovering the immune pathways driving the transition from the onset ...